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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
116 Results for "
Persistent
" in MedChemExpress (MCE) Product Catalog:
Products (116)
116 Results for "Persistent" in MCE Product Catalog:
Referencia número: HY-147256A
No. CAS: 1276021-10-3
Synonyms: Niferidil
Target:
Áreas de investigación:
Cavutilide hydrochloride (Niferidil) is a class III antiarrhythmic agent that inhibits hERG K + channel. Cavutilide hydrochloride has the potential for the study of persistent atrial fibrillation .
Referencia número: HY-W703863S
Referencia número: HY-U00069
No. CAS: 155273-01-1
Target:
Áreas de investigación:
Thionisoxetine is a norepinephrine transporter inhibitor with a Ki value of 0.2 nM in rats, and exhibits anti-hyperalgesic and analgesic activities. Thionisoxetine reverses thermal hyperalgesia and mechanical allodynia in rats. Thionisoxetine can be used in studies related to persistent inflammatory pain .
Referencia número: HY-182387
No. CAS: 208986-26-9
Áreas de investigación:
NM404 is a targeted radionuclide processing agent with slow clearance. Radioiodine-labeled NM404 is a small-molecule phospholipid ether analog that exhibits significant tumor uptake capacity and persistent tumor retention properties in more than 45 spontaneous and xenograft tumor models .
Referencia número: HY-116066
No. CAS: 183173-00-4
Target:
Áreas de investigación:
YM471 free base is a non-peptide antagonist of vasopressin V1A and V2 receptors with potent and persistent antagonistic activity. YM471 exhibits high affinity for rat V1A and V2 receptors with K values of 0.16 and 0.77 nM, respectively .
Referencia número: HY-186290
(-)-DMNP is an inhibitor targeting RelZ and Rel_Msm, with activity against mycobacteria. (-)-DMNP binds to structurally similar sites of RelZ and Rel_Msm, thereby inhibiting (p) ppGpp synthesis activity. (-)-DMNP inhibits the formation of persistent mycobacterial cells and eradicates their biofilms. (-)-DMNP can be used in the research of bacterial infections and tuberculosis .
Referencia número: HY-113798
No. CAS: 112887-62-4
Target:
Áreas de investigación:
ICI 198583 is a thymidylate synthase (TS) inhibitor with a Ki value of 10 nM for both mouse and human TS. ICI 198583 serves as a substrate for folylpolyglutamate synthetase (FPGS) with a Km of 40 μM. ICI 198583 exerts persistent, dose-dependent inhibition on thymidylate synthase flux in mice. ICI 198583 is applicable to relevant research on leukemia .
Referencia número: HY-187733
No. CAS: 77016-85-4
Target:
Áreas de investigación:
Plomestane is an orally active second-generation steroidal aromatase inhibitor that, as an enzyme-activated pseudosubstrate, is converted via NADPH-dependent catalysis into a reactive intermediate, which covalently binds to aromatase to produce irreversible inhibition, thereby persistently suppressing peripheral aromatase activity. Plomestane can be used for the study of hormone-dependent breast cancer .
Referencia número: HY-DY1122
No. CAS: 121461-69-6
Target:
Áreas de investigación:
Pyrromethene 556 (solution) is a fluorescent dipyrromethene-BF2 complex laser dye. Pyrromethene 556 (solution) enables immediate and reversible color changes in conventional glass ionomer restorative materials, while it does not cause persistent, visually detectable color changes in other restorative materials .
Solvent and concentration: DMSO: 10 mM
Solvent and concentration: DMSO: 10 mM
Referencia número: HY-167212
No. CAS: 50733-99-8
Target:
Áreas de investigación:
AHR-5645B free base inhibits the binding of 3H-spiperone to membrane sites in the bovine anterior pituitary and blocks the persistent inhibitory effect of dopamine on prolactin secretion. AHR-5645B free base stimulates prolactin secretion in male Sprague-Dawley rats in vivo .
Referencia número: HY-181987
Target:
Áreas de investigación:
PSCdb01560 is a Dengue virus NS5 RNA-dependent RNA polymerase (RdRp) inhibitor. PSCdb01560 binds stably to the conserved allosteric N-pocket of the polymerase, maintains persistent interactions with key residues Arg729 and Arg737, and induces polymerase structure stabilization. PSCdb01560 can be used for the research of dengue virus infection .
Target:
Áreas de investigación:
Fenticlor is a topical antibacterial agent that can be used for treating acne. Fenticlor can cause photosensitivity reactions and is a known cause of phototoxic dermatitis .
Referencia número: HY-182922
No. CAS: 3054394-56-5
SD-965 is a selective STAT3 PROTAC degrader with a DC50 of 0.14 μM. SD-965 promotes the ubiquitination and degradation of STAT3. SD-965 induces rapid, complete and persistent depletion of STAT3 protein. SD-965 induces tumor regression in mouse xenograft models of leukemia and lymphoma .
Referencia número: HY-182351
No. CAS: 253306-39-7
Target:
Áreas de investigación:
ONO-2921 is an orally active and selective N-type calcium channel blocker. ONO-2921 functionally blocks N-type calcium channels. ONO-2921 reduces paw withdrawal responses during persistent nociception and hyperalgesia to heat in neuropathic pain models. ONO-2921 can be used for research on neuropathic pain and nociceptive pain .
Referencia número: HY-W714852
No. CAS: 1315501-18-8
Target:
Áreas de investigación:
Zeta-Cypermethrin is a type II pyrethroid insecticide. Zeta-Cypermethrin primarily acts on voltage-gated sodium channels in nerve cells, causing delayed channel closure, persistent nerve excitation and convulsions. In Drosophila, Zeta-Cypermethrin rapidly induces extremely high metabolic resistance that can be screened, and exhibits in vitro genotoxicity to human peripheral blood lymphocytes .
Referencia número: HY-W415856
No. CAS: 7296-64-2
Synonyms: Beta-D-galactose
Target:
Áreas de investigación:
β-D-galactose (Beta-D-galactose) is one of the two anomers of D-Galactose (HY-N0210). β-D-galactose efficiently binds to and inhibits the galactose repressor (GalR), thereby inducing the expression of the gal regulon. β-D-galactose acts as a persistent induction signal to trigger the synthesis of UDP-galactose for the biosynthetic glycosylation pathway, rather than serving as a carbon source in Yersinia pestis with inactivated GalM .
Referencia número: HY-W162231
No. CAS: 91216-38-5
Target:
Áreas de investigación:
HC102A is an Antibacterial agent and an inhibitor of DosS and DosT histidine sensor kinases, with an IC50 of 1.9 μM against Mycobacterium tuberculosis DosS. HC102A does not alter the heme redox state of sensor kinases. HC102A reduces triacylglycerol synthesis and accumulation, decreases the survival rate of Mtb under non-replicating persistent and hypoxic conditions, and enhances the sensitivity of Mtb to Isoniazid (HY-B0329). HC102A can be used in research related to tuberculosis .
Referencia número: HY-167075
No. CAS: 851510-67-3
Target:
Áreas de investigación:
ASP4000 free base is an orally effective dipeptidyl peptidase 4 (DPP4) inhibitor, with an IC50 value of 2.25 nM against human recombinant DPP4, and exhibits hypoglycemic activity. By inhibiting DPP4 activity, ASP4000 free base reduces the degradation of active glucagon-like peptide-1 (GLP-1), thereby persistently increasing postprandial active GLP-1 levels and improving glycemic control. ASP4000 free base can be used in studies related to type 2 diabetes .
Referencia número: HY-182305
No. CAS: 2411865-57-9
VKT-17-P4-23 is a blood-brain barrier-permeable DksA inhibitor. DksA is a highly conserved transcriptional regulator in Gram-negative bacteria, with a Kd of 124 μM. Through the DksA-regulated, SPI-2-dependent survival pathway, VKT-17-P4-23 exhibits antibacterial activity against both planktonic and intracellular pathogens such as Salmonella, and also effectively combats persistent bacteria that are difficult to eliminate. VKT-17-P4-23 can be used in studies of Salmonella infection .
Referencia número: HY-182336
Target:
Áreas de investigación:
DeDPP4 is a DPP-4 PROTAC degrader. DeDPP4 induces sustained elevation of glucagon-like peptide-1 (GLP-1), enhances glucose tolerance, causes persistent reduction of blood glucose, and achieves long-term blood glucose regulation in animal models of type 2 diabetes. DeDPP4 mediates dose-dependent DPP-4 depletion in cancer cells, and also targets and degrades DPP-4 in the liver and adipose tissues of animal models with type 2 diabetes. DeDPP4 can be used for the research of type 2 diabetes and non-small cell lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
