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Cat. No.: HY-167212

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AHR-5645B free base

AHR-5645B free base inhibits the binding of ³H-spiperone to membrane sites in the bovine anterior pituitary and blocks the persistent inhibitory effect of dopamine on prolactin secretion. AHR-5645B free base stimulates prolactin secretion in male Sprague-Dawley rats in vivo.

For research use only. We do not sell to patients.

CAS No.: 50733-99-8
Formula: C₁₈H₂₇N₃O
Molecular Weight:301.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AHR-5645B free base Chemical Structure

CAS No.: 50733-99-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

AHR-5645B (six to eight concentrations; 10 min) free base inhibits specific ³H-spiperone binding to bovine anterior pituitary membranes with an IC₅₀ of 14400 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AHR-5645B (0.09 μmol/kg; i.p.; single dose) free base stimulates rat prolactin secretion in vivo with an ED₂₀₀ of 0.09 μmol/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, 175-225 g)^[1]
Dosage:

0.09 μmol/kg
Administration:

i.p.; single dose
Result:

Achieved an ED₂₀₀ of 0.09 μmol/kg, corresponding to a 100% increase in serum prolactin levels.

Chemical Information

CAS No. 50733-99-8
Molecular Weight 301.43
Formula C₁₈H₂₇N₃O
SMILES

O=C(C1=CC=C(N)C=C1)N(C)C2CN(CC2)C3CCCCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Meltzer HY, et al. Effects of a series of substituted benzamides on rat prolactin secretion and 3H-spiperone binding to bovine anterior pituitary membranes. Life Sci. 1983 Jun 20;32(25):2877-86.

[2]. Graybiel A, et al. Evaluation of a new antinauseant drug for the prevention of motion sickness. Aviat Space Environ Med. 1977 Sep;48(9):867-71. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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