50733-99-8
50733-99-8
Chemical Structure
AHR-5645B free base
- CAS No.: 50733-99-8
- Formula:C18H27N3O
- Molecular Weight:301.43
IUPAC Name: 4-amino-N-(1-cyclohexylpyrrolidin-3-yl)-N-methylbenzamide
InChIKey: BCZLLYRBOISBCG-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(N)C=C1)N(C)C2CN(CC2)C3CCCCC3
Biological Activity: AHR-5645B free base inhibits the binding of 3H-spiperone to membrane sites in the bovine anterior pituitary and blocks the persistent inhibitory effect of dopamine on prolactin secretion. AHR-5645B free base stimulates prolactin secretion in male Sprague-Dawley rats in vivo[1][2].
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AHR-5645B free base | AHR-5645B free base inhibits the binding of 3H-spiperone to membrane sites in the bovine anterior pituitary and blocks the persistent inhibitory effect of dopamine on prolactin secretion. AHR-5645B free base stimulates prolactin secretion in male Sprague-Dawley rats in vivo. | |||||||||||||||||||||
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References
- [1]. Meltzer HY, et al. Effects of a series of substituted benzamides on rat prolactin secretion and 3H-spiperone binding to bovine anterior pituitary membranes. Life Sci. 1983 Jun 20;32(25):2877-86.
- [2]. Graybiel A, et al. Evaluation of a new antinauseant drug for the prevention of motion sickness. Aviat Space Environ Med. 1977 Sep;48(9):867-71. [Content Brief]
