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Cat. No.: HY-186290

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(-)-DMNP

(-)-DMNP is an inhibitor targeting RelZ and Rel_Msm, with activity against mycobacteria. (-)-DMNP binds to structurally similar sites of RelZ and Rel_Msm, thereby inhibiting (p) ppGpp synthesis activity. (-)-DMNP inhibits the formation of persistent mycobacterial cells and eradicates their biofilms. (-)-DMNP can be used in the research of bacterial infections and tuberculosis.

For research use only. We do not sell to patients.

Formula: C₁₇H₂₄O₂
Molecular Weight:260.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(-)-DMNP Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

(-)-DMNP (1.06 mM; 0-48 h) potently reduces persister cell survival in stationary-phase Mycobacterium smegmatis mc² 155 cells, with greater activity than racemic DMNP and no activity observed from the (+)-DMNP enantiomer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Mycobacterium smegmatis mc² 155 wild-type strain
Concentration:

1.06 mM
Incubation Time:

0-48 h
Result:

Reduced survivor cell numbers in stationary-phase cells, with survival declining to near undetectable levels by 24 h.
Exhibited slightly greater activity than racemic DMNP mixture.
Showed far greater activity than (+)-DMNP, which had no noticeable antipersister activity.

Chemical Information

Molecular Weight 260.37
Formula C₁₇H₂₄O₂
SMILES

C[C@@H]1CC[C@]([C@H](C)CCC(O)=O)([H])C2=CC(C)=CC=C21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tkachenko AG, et al. A synthetic diterpene analogue inhibits mycobacterial persistence and biofilm formation by targeting (p)ppGpp synthetases. Cell chemical biology. 2021 Oct 21;28(10):1420-1432.e9.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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