Zeta-Cypermethrin 

Zeta-Cypermethrin is a type II pyrethroid insecticide. Zeta-Cypermethrin primarily acts on voltage-gated sodium channels in nerve cells, causing delayed channel closure, persistent nerve excitation and convulsions. In Drosophila, Zeta-Cypermethrin rapidly induces extremely high metabolic resistance that can be screened, and exhibits in vitro genotoxicity to human peripheral blood lymphocytes^[1][2].

Zeta-cypermethrin (6-30 μg/mL; 24 h) induces concentration-dependent DNA damage in human peripheral blood lymphocytes^[1].
Zeta-cypermethrin (6-60 μg/mL; 24 h) does not reduce viability of human peripheral blood lymphocytes at concentrations up to 30 μg/mL, but significantly reduces viability to 80% at 45 μg/mL and induces complete cell death at 60 μg/mL in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

416.30

C₂₂H₁₉Cl₂NO₃

1315501-18-8

C(O[C@H](C#N)C1=CC(OC2=CC=CC=C2)=CC=C1)(=O)C3C(C=C(Cl)Cl)C3(C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Calderón-Segura ME, et al. In vitro cytotoxicity and genotoxicity of Furia^®180 SC (zeta-cypermethrin) and Bulldock 125^®SC (β-cyfluthrin) pyrethroid insecticides in human peripheral blood lymphocytes. Toxicol Mech Methods. 2018;28(4):268-278.

  [2]. Mertz RW, et al. Selection for, and characterization of, malathion and zeta‐cypermethrin resistance in vineyard‐collected Drosophila melanogaster. Pest Management Science. 2023 Apr;79(4):1623-7.