Zeta-Cypermethrin
Zeta-Cypermethrin is a type II pyrethroid insecticide. Zeta-Cypermethrin primarily acts on voltage-gated sodium channels in nerve cells, causing delayed channel closure, persistent nerve excitation and convulsions. In Drosophila, Zeta-Cypermethrin rapidly induces extremely high metabolic resistance that can be screened, and exhibits in vitro genotoxicity to human peripheral blood lymphocytes.
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- CAS No.: 1315501-18-8
- Formula: C22H19Cl2NO3
- Molecular Weight:416.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
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Help & FAQs
Biological Activity
Description
In Vitro
Zeta-cypermethrin (6-30 μg/mL; 24 h) induces concentration-dependent DNA damage in human peripheral blood lymphocytes[1].
Zeta-cypermethrin (6-60 μg/mL; 24 h) does not reduce viability of human peripheral blood lymphocytes at concentrations up to 30 μg/mL, but significantly reduces viability to 80% at 45 μg/mL and induces complete cell death at 60 μg/mL in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1315501-18-8
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Molecular Weight 416.30
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Formula C22H19Cl2NO3
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SMILES
C(O[C@H](C#N)C1=CC(OC2=CC=CC=C2)=CC=C1)(=O)C3C(C=C(Cl)Cl)C3(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Genotoxicity/Mutagenicity Study
The bacterial reverse mutation assay detects point mutations that restore amino-acid prototrophy in auxotrophic Salmonella typhimurium or Escherichia coli tester strains; after exposure to a test article, mutagenic activity is read out as an increased number of revertant colonies on minimal agar compared with the vehicle control. The assay uses tester strains with different mutation targets so that base-substitution and frameshift mutagens can be detected, and testing is performed with and without exogenous mammalian metabolic activation because some chemicals require biotransformation to become mutagenic.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Zeta-Cypermethrin Related Classifications
HY-W714852 Related Classifications
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