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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
115 Results for "
surface expression
" in MedChemExpress (MCE) Product Catalog:
Products (115)
115 Results for "surface expression" in MCE Product Catalog:
Cat. No.: HY-D3435
Target:
Research Areas:
Biotin-X-DHPE is a biotin-labeled phospholipid analog that can be used for semi-automated cell panning in antibody discovery. Biotin-X-DHPE enables stable immobilization of live cells on magnetic beads without damaging the cells or altering their surface protein expression levels, while ensuring that the selected antibodies recognize natural, functional epitopes on the cell surface .
Cat. No.: HY-P77644
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: ECSCR; Apoptosis Regulator Through Modulating IAP expression; Endothelial Cell surface Expressed Chemotaxis And Apoptosis Regulator; Endothelial Cell-Specific Chemotaxis Regulator; ECSM2; Endothelial Cell-Specific Molecule 2; ARIA
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P77919
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: ECSCR; Apoptosis Regulator Through Modulating IAP expression; Endothelial Cell surface Expressed Chemotaxis And Apoptosis Regulator; Endothelial Cell-Specific Chemotaxis Regulator; ECSM2; Endothelial Cell-Specific Molecule 2; ARIA
Species:
Human
Source:
HEK293
Cat. No.: HY-P11450
CAS No.: 3084349-53-8
Target:
Research Areas:
Cat. No.: HY-N19733
CAS No.: 79147-77-6
Target:
Cat. No.: HY-181347
CAS No.: 2346450-55-1
GLPG3808 is an orally active PAPD5/7 inhibitor. GLPG3808 inhibits the expression of HBcAg in various cells infected with HBV. GLPG3808 reduces the hepatitis B surface antigen levels in HBV-infected animal models. GLPG3808 can be used for the research of hepatitis B virus infection .
Cat. No.: HY-182533
CAS No.: 3035425-93-2
Target:
Research Areas:
LN5972 is a selective ACKR3 agonist with an EC50 of 3.40 μM, showing higher selectivity for ACKR3 over CXCR4. LN5972 induces β-arrestin recruitment to ACKR3/CXCR7. LN5972 reduces the surface expression of P-selectin. LN5972 is applicable to studies related to platelet-mediated thrombosis .
Cat. No.: HY-182674
CAS No.: 1322645-32-8
Target:
VGD020 is a highly potent and selective Sec61 translocon inhibitor . VGD020 suppresses the expression of cell surface CD4 by inhibiting signal peptide-dependent co-translational ER translocation, interferes with the initiation of ER translocation of dengue virus polyprotein, and reduces the expression of Sortilin in breast cancer cells. VGD020 exhibits broad anti-flavivirus and anti-HIV activities. VGD020 can be used in research related to dengue virus infection, Zika virus infection, yellow fever virus infection, human immunodeficiency virus infection, and breast cancer .
Cat. No.: HY-171239
CAS No.: 656831-19-5
Target:
Research Areas:
Ste2Cys is a diacylglycerol cysteine-type immunologic adjuvant lipid molecule. Ste2Cys can bind to TLR2 and activate NF-κB signaling pathway. Ste2Cy can upregulate the expression of MHC II class molecules on the surface of mouse bone marrow-derived D1 dendritic cells. Ste2Cys can be used for research of the development of immunologic vaccines .
Cat. No.: HY-E71367
Target:
Research Areas:
Cardiovascular Disease Infection Inflammation/Immunology Cancer
Bromelain USP is an orally active proteolytic agent. Bromelain USP converts plasminogen to plasmin to support fibrinolysis, cleaves CD44 adhesion molecules from cell surfaces, and diminishes uPAR expression and uPA activity. Bromelain USP can inhibit the activity of a variety of fungi and bacteria. Bromelain USP can be used for the research of angina pectoris, atherosclerotic disease, fungal infections, bacterial infections, chronic inflammatory bowel disease, and cancer .
Cat. No.: HY-P1058
CAS No.: 243843-42-7
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Cat. No.: HY-108839
CAS No.: 198153-51-4
Synonyms: Ro 25-8310/000
Peginterferon alfa-2a (Ro 25-8310/000) is a 40 kDa branched pegylated IFN alfa-2a with antiviral and immunomodulatory activities. Peginterferon alfa-2a binds to the Interferon Receptor on the surface of target cells, induces the formation of ISGF3, and promotes the expression of effector proteins such as interferon-stimulated genes (ISGs) and Mx proteins, thereby exerting sustained antiviral effects. Peginterferon alfa-2a is applicable to research on virus infections associated with chronic hepatitis C and chronic hepatitis B .
Cat. No.: HY-184379
CAS No.: 2358714-71-1
SRI-37264 is a HIV-1 Nef inhibitor with a Kd value of 162 nM. SRI-37264 binds directly to HIV-1 Nef, disrupts the Nef·MHC-I·AP-1 μ1 complex, and inhibits the Nef-dependent enhancement of HIV-1 infectivity. SRI-37264 restores MHC-I expression on the surface of HIV-infected primary cells. SRI-37264 inhibits HIV-1 replication in primary macrophages. SRI-37264 is applicable to research related to HIV-1 infection .
Cat. No.: HY-N11293
CAS No.: 51415-07-7
Category:
Target:
Cat. No.: HY-P991734A
Target:
Research Areas:
VHB937 (IgG1-LALA) is a derivative of VHB937 (HY-P991734). VHB937 is a human monoclonal antibody that acts as a potent and selective TREM2 agonist. VHB937 enhances the surface expression of TREM2 and its downstream signaling pathways, such as Syk phosphorylation and calcium mobilization. VHB937 has demonstrated significant neuroprotective effects in various animal models of neuroinflammation and neurodegeneration, effectively alleviating pathological damage and reducing pro-inflammatory marker levels. VHB937 can be used in research related to neurodegenerative diseases.
Cat. No.: HY-P992062
Target:
Research Areas:
Cat. No.: HY-P992437
Research Areas:
Cat. No.: HY-L132
257 compounds
Chemokines, or chemotactic cytokines, are small cytokines or signaling proteins secreted by cells. They are a component of intercellular communication, controlling the directional movement of immune cells especially leukocytes, as well as other cell types, for instance, endothelial and epithelial cells, which are essential to maintain human health and the function of the immune system.
The biological effects of chemokines are achieved by binding to chemokine receptors, which are G protein-coupled receptors found on the surface of leukocytes. Some chemokine receptors are involved in directing tumor metastasis and over-expression by certain tumors. So inhibiting the interaction between chemokine and chemokine receptors on the surface of tumor cells may be a new possible therapeutic approach. Some chemokine receptors are coreceptors for HIV entry, and related inhibitors have been approved by the FDA to treat patients with HIV. Obviously, chemokines and chemokine receptors have become new targets for studying cancer, HIV, inflammation, and other diseases.
MCE supplies a unique collection of 257 chemokine or chemokine receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on chemokine or chemokine receptors. MCE Chemokine Library is a useful tool for drug research related to cancer, AIDS, and wound therapy.
Cat. No.: HY-10624R
CAS No.: 312637-48-2
Research Areas:
THIQ (Standard) is the analytical standard of THIQ (HY-10624). This product is intended for research and analytical applications. THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
