51415-07-7
Chemical Structure
Momilactone A
- CAS No.: 51415-07-7
- Formula:C20H26O3
- Molecular Weight:314.43
IUPAC Name: (3aR,3a1R,5aR,8R,10aR,10bR)-3a,8,10b-trimethyl-8-vinyl-1,3a,3a1,5a,7,8,9,10,10a,10b-decahydro-3H-phenanthro[10,1-bc]furan-3,4(2H)-dione
InChIKey: MPHXYQVSOFGNEN-JGHPTVLTSA-N
SMILES: C[C@]12[C@]3([C@@](C=C4[C@]1(CC[C@](C=C)(C)C4)[H])(OC(=O)[C@@]3(C)C(=O)CC2)[H])[H]
Biological Activity: Momilactone A is a naturally derived diterpene lactone with multiple biological activities including anticancer, antibacterial and antioxidant properties. Momilactone A inhibits inflammatory responses by reducing NO production and iNOS expression. Momilactone A acts as a corrosion inhibitor for mild steel; it forms an isolating film on the metal surface via adsorption between oxygen atoms of the molecule and iron ions, thereby blocking corrosive media. Momilactone A inhibits the growth of fungal and bacterial organisms, and also functions as an allelochemical to inhibit the growth of adjacent competing plants. Momilactone A can be used in studies related to leukemia, fungal infections and bacterial infections[1][2][3].
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Momilactone A | Momilactone A is a naturally derived diterpene lactone with multiple biological activities including anticancer, antibacterial and antioxidant properties. Momilactone A inhibits inflammatory responses by reducing NO production and iNOS expression. Momilactone A acts as a corrosion inhibitor for mild steel; it forms an isolating film on the metal surface via adsorption between oxygen atoms of the molecule and iron ions, thereby blocking corrosive media. Momilactone A inhibits the growth of fungal and bacterial organisms, and also functions as an allelochemical to inhibit the growth of adjacent competing plants. Momilactone A can be used in studies related to leukemia, fungal infections and bacterial infections. | |||||||||||||||||||||
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References
- [1]. Anh H, et al. Cytotoxic Mechanism of Momilactones A and B against Acute Promyelocytic Leukemia and Multiple Myeloma Cell Lines. Cancers. 2022 Oct 04;14(19):4848. [Content Brief]
- [2]. Prabakaran M, et al. Anticorrosion properties of momilactone A isolated from rice hulls. Journal of Industrial and Engineering Chemistry, 2017, 45: 380-386.
- [3]. Kato-Noguchi H, et al. Defensive Molecules Momilactones A and B: Function, Biosynthesis, Induction and Occurrence. Toxins. 2023 Mar 25;15(4):241. [Content Brief]
