Momilactone A
Momilactone A is a naturally derived diterpene lactone with multiple biological activities including anticancer, antibacterial and antioxidant properties. Momilactone A inhibits inflammatory responses by reducing NO production and iNOS expression. Momilactone A acts as a corrosion inhibitor for mild steel; it forms an isolating film on the metal surface via adsorption between oxygen atoms of the molecule and iron ions, thereby blocking corrosive media. Momilactone A inhibits the growth of fungal and bacterial organisms, and also functions as an allelochemical to inhibit the growth of adjacent competing plants. Momilactone A can be used in studies related to leukemia, fungal infections and bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 51415-07-7
- Formula: C20H26O3
- Molecular Weight:314.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[3]|
iNOS |
In Vitro
Momilactone A (MA) (0.5-10 μM; 48 h) exhibits only mild cytotoxicity toward non-cancerous MeT-5A cells, and shows weak cytotoxicity toward both acute promyelocytic leukemia HL-60 cells and multiple myeloma U266 cells[1].
Momilactone A inhibits the corrosion of mild steel in 1 M HCl by adsorbing at the metal-solution interface, and reduces the formation of iron oxide on the surface of mild steel immersed in 1 M HCl for 3 h[2].
Momilactone A inhibits phytopathogenic fungi such as Magnaporthe oryzae, as well as common soil bacteria and human-associated bacteria[3].
Momilactone A inhibits the inflammatory response of mouse macrophage RAW264.7 by reducing NO production and iNOS mRNA expression[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:non-cancerous MeT-5A mesothelial cells, acute promyelocytic leukemia HL-60 cells, multiple myeloma U266 cells
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Concentration:0.5, 1, 5, 10 μM
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Incubation Time:48 h
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Result:Exhibited 28.52% inhibition of MeT-5A cell viability at 10 μM.
Showed 30.25% inhibition of HL-60 cell viability at 10 μM.
Showed 40.97% inhibition of U266 cell viability at 10 μM.
Had no IC50 values determined against HL-60 or U266 cells.
Chemical Information
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CAS No. 51415-07-7
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Molecular Weight 314.43
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Formula C20H26O3
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SMILES
C[C@]12[C@]3([C@@](C=C4[C@]1(CC[C@](C=C)(C)C4)[H])(OC(=O)[C@@]3(C)C(=O)CC2)[H])[H]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
Purity & Documentation
References
[1]. Anh H, et al. Cytotoxic Mechanism of Momilactones A and B against Acute Promyelocytic Leukemia and Multiple Myeloma Cell Lines. Cancers. 2022 Oct 04;14(19):4848. [Content Brief]
[3]. Kato-Noguchi H, et al. Defensive Molecules Momilactones A and B: Function, Biosynthesis, Induction and Occurrence. Toxins. 2023 Mar 25;15(4):241. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Momilactone A Related Classifications
HY-N11293 Related Classifications
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