Momilactone A
Momilactone A is a naturally derived diterpene lactone with multiple biological activities including anticancer, antibacterial and antioxidant properties. Momilactone A inhibits inflammatory responses by reducing NO production and iNOS expression. Momilactone A acts as a corrosion inhibitor for mild steel; it forms an isolating film on the metal surface via adsorption between oxygen atoms of the molecule and iron ions, thereby blocking corrosive media. Momilactone A inhibits the growth of fungal and bacterial organisms, and also functions as an allelochemical to inhibit the growth of adjacent competing plants. Momilactone A can be used in studies related to leukemia, fungal infections and bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 51415-07-7
- Formula: C20H26O3
- Molecular Weight:314.43
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
iNOS |
Momilactone A (MA) (0.5-10 μM; 48 h) exhibits only mild cytotoxicity toward non-cancerous MeT-5A cells, and shows weak cytotoxicity toward both acute promyelocytic leukemia HL-60 cells and multiple myeloma U266 cells[1].
Momilactone A inhibits the corrosion of mild steel in 1 M HCl by adsorbing at the metal-solution interface, and reduces the formation of iron oxide on the surface of mild steel immersed in 1 M HCl for 3 h[2].
Momilactone A inhibits phytopathogenic fungi such as Magnaporthe oryzae, as well as common soil bacteria and human-associated bacteria[3].
Momilactone A inhibits the inflammatory response of mouse macrophage RAW264.7 by reducing NO production and iNOS mRNA expression[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:non-cancerous MeT-5A mesothelial cells, acute promyelocytic leukemia HL-60 cells, multiple myeloma U266 cells
-
Concentration:0.5, 1, 5, 10 μM
-
Incubation Time:48 h
-
Result:Exhibited 28.52% inhibition of MeT-5A cell viability at 10 μM.
Showed 30.25% inhibition of HL-60 cell viability at 10 μM.
Showed 40.97% inhibition of U266 cell viability at 10 μM.
Had no IC50 values determined against HL-60 or U266 cells.
Chemical Information
-
CAS No. 51415-07-7
-
Molecular Weight 314.43
-
Formula C20H26O3
-
SMILES
C[C@]12[C@]3([C@@](C=C4[C@]1(CC[C@](C=C)(C)C4)[H])(OC(=O)[C@@]3(C)C(=O)CC2)[H])[H]
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Anh H, et al. Cytotoxic Mechanism of Momilactones A and B against Acute Promyelocytic Leukemia and Multiple Myeloma Cell Lines. Cancers. 2022 Oct 04;14(19):4848. [Content Brief]
[3]. Kato-Noguchi H, et al. Defensive Molecules Momilactones A and B: Function, Biosynthesis, Induction and Occurrence. Toxins. 2023 Mar 25;15(4):241. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Momilactone A Related Classifications
HY-N11293 Related Classifications
Powered by Bioz