115 Results for "

surface expression

" in MedChemExpress (MCE) Product Catalog:
Products (115)

115 Results for "surface expression" in MCE Product Catalog:

Cat. No.: HY-P5764
CAS No.: 141923-36-6
TRAP-14 amide, a proteinase activated receptor (PAR)-activating peptide, is a PAR agonist with an EC50 of 24 μM. TRAP-14 amide significantly induces platelet aggregation through ADP- and MMP-2-dependent pathways with Aspirin (HY-14654)-insensitivity. TRAP-14 amide also effectively increases glycoprotein (GP) Ib and GPIIb/IIIa surface expression and ADP release .
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Cat. No.: HY-150749
CAS No.: 1198621-85-0
Target:  

IFNAR

Research Areas:  

Inflammation/Immunology Cancer

ODN D-SL03 is a C class CpG oligonucleotides, can induce stimulate PBMCs to produce high level of IFN-α. ODN D-SL03 can activate human B cells, NK cells and mononuclear cells and up-regulate expression of CD80, CD86 and HLA-DR on the surface of subsets in human PBMCs. ODN D-SL03 also can inhibit the growth of the tumor. ODN D-SL03 sequence: 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3' .
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Cat. No.: HY-W1123936E
Synonyms: DBCO-PEG5000-Folate
DBCO-PEG5000-FA (DBCO-PEG5000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folate receptors (FR). Folate receptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
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Cat. No.: HY-W1123936H
Synonyms: DBCO-PEG10000-Folate
DBCO-PEG10000-FA (DBCO-PEG10000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folate receptors (FR). Folate receptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications .
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Cat. No.: HY-134809A
CAS No.: 392287-03-5
Synonyms: CADA hydrochloride
Target:  

HIV

Research Areas:  

Infection

Cyclotriazadisulfonamide (CADA) hydrochloride is a specific CD4-targeted HIV entry inhibitor with activity against HIV-1 replication. Cyclotriazadisulfonamide hydrochloride can specifically downregulate the expression of CD4 receptors on the cell surface, effectively inhibiting HIV transmission. Cyclotriazadisulfonamide hydrochloride can inhibit HIV-1(NL4.3) and SIV(mac251), and has a synergistic effect when used in combination with cellulose acetate (CAP). Cyclotriazadisulfonamide hydrochloride can also be used as a microbial gel formulation to maintain CD4 downregulation and antiviral activity, and is a broad-spectrum anti-HIV agent.
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Cat. No.: HY-W002438R
CAS No.: 2380-86-1
6-Hydroxyindole (Standard) is the analytical standard of 6-Hydroxyindole (HY-W002438). This product is intended for research and analytical applications. 6-Hydroxyindole is an orally active, endogenous long-acting OATP1B1 inhibitor. 6-Hydroxyindole does not alter the cell surface expression or subcellular localization of OATP1B1. 6-Hydroxyindole protects cells against Ferroptosis. 6-Hydroxyindole possesses intrinsic radical-trapping antioxidant activity. 6-Hydroxyindole serves as a component of oxidative hair dyes. 6-Hydroxyindole can be used in research related to renal failure and neurodegenerative diseases .
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Cat. No.: HY-B0507AR
CAS No.: 144-74-1
Research Areas:  

Endocrinology Cancer

Sulfathiazole sodium (Standard) is the analytical standard of Berberine sodium (HY-B0507A). This product is intended for research and analytical applications. Sulfathiazole sodium is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole sodium increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish. Sulfathiazole sodium is also a cathodic corrosion inhibitor. Sulfathiazole sodium inhibits the corrosion of copper by chloride ions through chemical and physical adsorption on the copper surface, reduces the corrosion current density and shifts the corrosion potential negatively .
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Cat. No.: HY-168384
CAS No.: 875158-73-9
M04 is an agonist of STING. It induces the expression of the IFN reporter gene in HEK293T cells expressing wild-type human STING, but does not induce this expression in HEK293T cells expressing the R71H-G230A-R293Q (HAQ) STING variant or in mouse RAW 264.7 cells, indicating that its activity is dependent on allelic and species variations. M04 induces the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs). At a concentration of 50 µM, M04 stimulates dendritic cells isolated from PBMCs to express the MHC class II cell surface receptor HLA-DR and co-stimulatory molecules CD40, CD80, and CD86, and also enhances their ability to activate T cells in an ex vivo assay. M04 can be used in research on inflammatory immune diseases .
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Cat. No.: HY-B0426AS2
Synonyms: ALO4943A-d6 hydrochloride; KW4679-d6 hydrochloride
Olopatadine-d6 (ALO4943A-d6; KW4679-d6) hydrochloride is deuterium-labeled Olopatadine (hydrochloride) (HY-B0426A). Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 + and CD8 + T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis .
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Cat. No.: HY-N0699R
CAS No.: 2034-69-7
Synonyms: Dephnoretin (Standard); Thymelol (Standard)
Daphnoretin (Dephnoretin; Thymelol) (Standard) is the analytical standard of Daphnoretin (HY-N0699). This product is used for research and analytical applications. Daphnoretin is a protein kinase C (PKC) activator that can inhibit the expression of hepatitis B virus (HBV) surface antigen (HBsAg) and has antiviral activity. Daphnoretin exerts its anti-tumor effect by inhibiting the activation of the PI3K/AKT signaling pathway, triggering the mitochondrial apoptosis pathway. Daphnoretin alleviates chondrocyte apoptosis and inflammatory responses by inhibiting endoplasmic reticulum stress and the activation of the NLRP3 inflammasome. Daphnoretin can regulate the differentiation and maturation of dendritic cells, by down-regulating the phosphorylation level of JNK, inhibiting its immune stimulating function, thereby playing a protective role in skin transplant rejection reactions.
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Cat. No.: HY-P72698
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD96; TACTILE; CD96 Molecule; T Cell Activation, Increased Late expression; T-Cell surface Protein Tactile; CD96 Antigen; T Cell-Activated Increased Late expression Protein; Alternative Protein CD96; Cell surface Antigen CD96
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P72699
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD96; TACTILE; CD96 Molecule; T Cell Activation, Increased Late expression; T-Cell surface Protein Tactile; CD96 Antigen; T Cell-Activated Increased Late expression Protein; Alternative Protein CD96; Cell surface Antigen CD96
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P78420
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD96; TACTILE; CD96 Molecule; T Cell Activation, Increased Late expression; T-Cell surface Protein Tactile; CD96 Antigen; T Cell-Activated Increased Late expression Protein; Alternative Protein CD96; Cell surface Antigen CD96
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P700686
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD96; TACTILE; CD96 Molecule; T Cell Activation, Increased Late expression; T-Cell surface Protein Tactile; CD96 Antigen; T Cell-Activated Increased Late expression Protein; Alternative Protein CD96; Cell surface Antigen CD96
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P700855
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD96; TACTILE; CD96 Molecule; T Cell Activation, Increased Late expression; T-Cell surface Protein Tactile; CD96 Antigen; T Cell-Activated Increased Late expression Protein; Alternative Protein CD96; Cell surface Antigen CD96
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P75371
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CD96; TACTILE; CD96 Molecule; T Cell Activation, Increased Late expression; T-Cell surface Protein Tactile; CD96 Antigen; T Cell-Activated Increased Late expression Protein; Alternative Protein CD96; Cell surface Antigen CD96
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P703883
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD96; TACTILE; CD96 Molecule; T Cell Activation, Increased Late expression; T-Cell surface Protein Tactile; CD96 Antigen; T Cell-Activated Increased Late expression Protein; Alternative Protein CD96; Cell surface Antigen CD96
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P78660
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD96; TACTILE; CD96 Molecule; T Cell Activation, Increased Late expression; T-Cell surface Protein Tactile; CD96 Antigen; T Cell-Activated Increased Late expression Protein; Alternative Protein CD96; Cell surface Antigen CD96
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P85013
Synonyms: CD96; T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; CD96; CD96 nanobody;

Host:  

Mouse

Application:  

ELISA

Reactivity:  

Human

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Cat. No.: HY-187589
CAS No.: 960521-38-4
Target:  

Monoamine Transporter

Research Areas:  

Neurological Disease

WY-46824 is a selective norepinephrine transporter (NET) inhibitor. WY-46824 does not alter the total expression level or cell surface expression level of hNET. WY-46824 can be used in related research on attention deficit hyperactivity disorder (ADHD) .
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