2380-86-1
Chemical Structure
6-Hydroxyindole
- CAS No.: 2380-86-1
- Formula:C8H7NO
- Molecular Weight:133.15
IUPAC Name: 1H-indol-6-ol
InChIKey: XAWPKHNOFIWWNZ-UHFFFAOYSA-N
SMILES: OC1=CC2=C(C=C1)C=CN2
Biological Activity: 6-Hydroxyindole is an orally active, endogenous long-acting OATP1B1 inhibitor. 6-Hydroxyindole does not alter the cell surface expression or subcellular localization of OATP1B1. 6-Hydroxyindole protects cells against Ferroptosis. 6-Hydroxyindole possesses intrinsic radical-trapping antioxidant activity. 6-Hydroxyindole serves as a component of oxidative hair dyes. 6-Hydroxyindole can be used in research related to renal failure and neurodegenerative diseases[1][2][3].
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6-Hydroxyindole | 99.61% | 6-Hydroxyindole is an orally active, endogenous long-acting OATP1B1 inhibitor. 6-Hydroxyindole does not alter the cell surface expression or subcellular localization of OATP1B1. 6-Hydroxyindole protects cells against Ferroptosis. 6-Hydroxyindole possesses intrinsic radical-trapping antioxidant activity. 6-Hydroxyindole serves as a component of oxidative hair dyes. 6-Hydroxyindole can be used in research related to renal failure and neurodegenerative diseases. | ||||||||||||||||||||
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6-Hydroxyindole (Standard) | ≥98% | 6-Hydroxyindole (Standard) is the analytical standard of 6-Hydroxyindole. This product is intended for research and analytical applications. 6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor, and is elevated plasma of the renal failure patients. | ||||||||||||||||||||
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- [1]. Masuo Y, et al. 6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients. Drug Metab Pharmacokinet. 2020;35(6):555-562. [Content Brief]
- [2]. Jakaria M, et al. The role of hydroxyindoles in protecting neuronal cultures from ferroptosis. Cell Death Discov. 2025;11(1):329. Published 2025 Jul 16. [Content Brief]
- [3]. Burnett CL, et al. Safety assessment of 6-hydroxyindole as used in cosmetics. Int J Toxicol. 2014;33(3 Suppl):24S-35S. [Content Brief]
