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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
139 Results for "
nonnucleoside reverse transcriptase
" in MedChemExpress (MCE) Product Catalog:
Products (139)
139 Results for "nonnucleoside reverse transcriptase" in MCE Product Catalog:
Cat. No.: HY-111147
CAS No.: 914496-19-8
RDEA-427 is a pyrrolopyrimidine derivative and also a HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). RDEA-427 acts on wild-type and NNRTI-resistant mutant HIV-1. RDEA-427 can be used in research related to HIV infection .
Cat. No.: HY-174417
CAS No.: 2459751-62-1
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NNRT-IN-10 is a potent, selective and orally active non-nucleoside HIV-1 reverse transcriptase (NNRTI) inhibitor with with an EC50 values ranging from 1.16 to 18.3 nM for HIV and its mutant strains. NNRT-IN-10 exhibits good pharmacokinetic properties and favorable safety profiles. NNRT-IN-10 can be used for the study of AIDS, caused by HIV-1 .
Cat. No.: HY-189211
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NNRT-IN-17 is a non-nucleoside HIV-1 Reverse Transcriptase inhibitor with an IC50 of 0.095 μM. NNRT-IN-17 exerts its inhibitory effect by binding to the NNRTI binding pocket and adjacent sites, and exhibits antiviral activity against wild-type and multiple NNRTI-resistant mutant strains. NNRT-IN-17 can be used for the study of HIV-1 infection (AIDS) .
Cat. No.: HY-10574S
CAS No.: 1312424-26-2
Cat. No.: HY-182552
CAS No.: 65025-62-9
Cat. No.: HY-144113
CAS No.: 2761172-65-8
HIV-1 inhibitor-14 (compound 14b) is a highly potent and broad-spectrum HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor with an EC50 of 0.14 μM for HIV-1 RT. HIV-1 inhibitor-14 has inhibitory activity against HIV-1 WT and resistant strains with EC50s of 5.79 ~ 28.3 nM .
Cat. No.: HY-146746
CAS No.: 2649837-82-9
HIV-1 inhibitor-19 is a potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). HIV-1 inhibitor-19 maintains its inhibitory activity against L100I, K103N and V106A/ F227L mutant strains with EC50s of 7.3 nM, 9.2 nM and 21.0 nM, respectively.
Cat. No.: HY-105097
CAS No.: 138540-32-6
Synonyms: U 87201E mesylate
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Atevirdine (U 87201E) mesylate is a nonnucleoside reverse transcriptase (NNRT) inhibitor. Atevirdine mesylate can inhibit human immunodeficiency virus type 1 (HIV-1) with an IC50 of 0.06-1.6 μM. Atevirdine mesylate shows highly synergistic effects against Zidovudine/Didanosine-resistant clinical isolates of HIV-1 companied with Zidovudine (HY-17413)/Didanosine (Hy-B0249). Atevirdine mesylate can be used for the research of AIDS .
Cat. No.: HY-105249
CAS No.: 878670-61-2
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RDEA 806 is an orally effective non-nucleoside reverse transcriptase (NNRT) inhibitor that exhibits potent in vitro inhibitory activity against wild-type HIV-1 (EC50 = 1.7 ng/mL) and NNRTI-resistant HIV-1. RDEA 806 rapidly reduces HIV-1 RNA viral load in vivo. RDEA 806 has a favorable biosafety profile. RDEA 806 can be used for research related to HIV-1 infection .
Cat. No.: HY-10574AR
CAS No.: 700361-47-3
Synonyms: TMC-278 hydrochloride (Standard); TMC278 hydrochloride (Standard); TMC 278 hydrochloride (Standard)
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Rilpivirine (hydrochloride) (Standard) is the analytical standard of Rilpivirine (hydrochloride). This product is intended for research and analytical applications. Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV .
Cat. No.: HY-10574R
CAS No.: 500287-72-9
Synonyms: R278474 (Standard); TMC278 (Standard); DB08864 (Standard)
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Rilpivirine (Standard) is the analytical standard of Rilpivirine. This product is intended for research and analytical applications. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .
Cat. No.: HY-10574S1
Synonyms: R278474-13C6; TMC278-13C6; DB08864-13C6
Cat. No.: HY-146018
CAS No.: 2554622-28-3
HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50 > 221 μM) and a favorable in vitro microsomal stability .
Cat. No.: HY-148642
CAS No.: 133627-24-4
Synonyms: 12-hydroxy-NVP; 12-OH-NVP
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12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine .
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PYR01 is a non-nucleoside reverse transcriptase inhibitor and a killing activator targeting HIV infected cells. PYR01 has cytokilling and antiviral properties of HIV-1 infection with the IC50 values of 27.5nM and 39.7nM, respectively. PYR01 leads to selective cytotoxicity by promoting HIV-1 Gag-Pol dimerization and HIV-1 protease intracellular activation. PYR01 can be used in the study of HIV .
Cat. No.: HY-17396R
CAS No.: 101827-46-7
Synonyms: KP363 Hydrochloride (Standard)
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Rilpivirine (hydrochloride) (Standard) is the analytical standard of Rilpivirine (hydrochloride). This product is intended for research and analytical applications. Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV .
Cat. No.: HY-164201
CAS No.: 257891-65-9
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HIV-1 inhibitor-69 is an HIV-1 reverse transcriptase inhibitor. HIV-1 inhibitor-69 protects cells against HIV-1 infection. HIV-1 inhibitor-69 can be used for the research of acquired immunodeficiency syndrome (AIDS) .
Cat. No.: HY-117725
CAS No.: 146739-86-8
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S-2720 is a potent inhibitor of both immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) and HIV-1 replication. The binding sites of S-2720 and the nonnucleoside compounds overlap. The small pocket in the p66 subunit-BI-RG-587 (HY-10570) complex is most likely the target of S-2720. S-2720 is a quinoxaline derivative, which is promising for research of HIV-1 infection .
Cat. No.: HY-118711
CAS No.: 149486-68-0
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HI-346 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1 with an IC50 value against the HIV-1 virus strain (HTLV-IIIB) of 3 nM. HI-346 is a vaginal bactericidal contraceptive agent, with its sperm-killing activity having an EC50 value of 42 μM. HI-346 shows no cytotoxicity to normal cells at effective concentrations. HI-346 can be used in anti-HIV-1 and contraceptive research .
Cat. No.: HY-147807
CAS No.: 2789676-44-2
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HIV-1 inhibitor-40 (Compound 4ab) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an EC50 of 1.9 nM. HIV-1 inhibitor-40 displays weak CYP sensitivity with IC50 values of 5.16 μM and 4.51 μM against CYP2C9 and CYP2C19, respectively. HIV-1 inhibitor-40 has no apparent in vivo acute toxicity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
