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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
175 Results for "
DPP4
" in MedChemExpress (MCE) Product Catalog:
Products (175)
175 Results for "DPP4" in MCE Product Catalog:
Cat. No.: HY-176000
CAS No.: 307345-51-3
Target:
Research Areas:
Sulphostin is a covalent inhibitor of dipeptidyl peptidase 4 (DPP4), dipeptidyl peptidase 9 (DPP9), and dipeptidyl peptidase 8 (DPP8) with IC50 values of 79, 1392, 6930 nM, respectively. Sulphostin causes phosphosulfamate modification, irreversibly inhibits the enzyme activity. Sulphostin can be used for inflammation and cancer study .
Cat. No.: HY-10285S
Synonyms: BMS-477118-15N,d2 Hydrochloride
Cat. No.: HY-12413A
CAS No.: 1610562-74-7
Research Areas:
BMS-986118 is an orally active and selective GPR40 full agonist (EC50 = 0.07 μM). BMS-986118 induces GLP-1 secretion and increases GLP-1 and insulin levels when combined with DPP-4 inhibitors. BMS-986118 shows sustained glucose-lowering effects. BMS-986118 can be used for research on type 2 diabetes [4] .
Cat. No.: HY-P81529A
Synonyms: ADCP2, CD26; DPP4; Dipeptidyl peptidase 4; ADABP; Adenosine deaminase complexing protein 2 (ADCP-2); Dipeptidyl peptidase IV (DPP IV); T-cell activation antigen CD26; TP103
Cat. No.: HY-117985
CAS No.: 1222102-29-5
Synonyms: DA-1229
Target:
Research Areas:
Evogliptin (DA-1229) is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation [4].
Cat. No.: HY-132489S1
CAS No.: 2749855-96-5
Synonyms: (Rac)-MK-0431-d4-1 hydrochloride
Cat. No.: HY-A0023AS2
Synonyms: SYR-322-13C,d3 benzoate
Cat. No.: HY-I0786
CAS No.: 1404559-15-4
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(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). (2S,4R)-Teneligliptin increases the plasma concentration of active glucagon-like peptide-1 (GLP-1), which promotes insulin secretion in response to elevated blood glucose levels, exerting hypoglycemic activity. (2S,4R)-Teneligliptin is promising for research of type 2 diabetes .
Cat. No.: HY-W741755S1
CAS No.: 1572922-53-2
Synonyms: GLP-1-Gly8; GLP-1 (7-36) analog
Target:
Research Areas:
Cat. No.: HY-108795A
Purity: 99.12%
Synonyms: GLP-1-Gly8 TFA; GLP-1 (7-36) analog TFA
Target:
Research Areas:
Cat. No.: HY-171454
CAS No.: 1914136-10-9
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DA-1241 is a GPR119 agonist. DA-1241 reduces macrophage differentiation through downregulation of NFκB signaling by activating GPR119. DA-1241, alone and in combination with a DPP4 inhibitor, reduces liver inflammation and restores inflammation-related liver gene expression. DA-1241 can be used for the research of metabolic dysfunction-associated steatohepatitis (MASH) .
Cat. No.: HY-167680
CAS No.: 483369-58-0
Synonyms: GSK823093
Target:
Research Areas:
Denagliptin (GSK823093) is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor with activity for the suppression of endocrine and metabolic diseases. Denagliptin can be used to study type 2 diabetes. Denagliptin is stable in the solid state but degrades in solution and in mixtures with various excipients. Denagliptin also exhibits degradation in capsules, mainly through cyclization reactions to form (3S,7S,8aS) aminoamines to provide further synthetic materials. The degradation pathway of Denagliptin was elucidated, providing data to support its formulation development and regulatory filings .
Cat. No.: HY-P705417
Purity: ≥ 90%, as determined by Bis-Tris PAGE.
Synonyms: DPP4; DPP IV; Prev. ADCP2; TP103; Prev. CD26; Post-Proline Dipeptidyl Aminopeptidase IV; Adenosine Deaminase Complexing Protein 2; Xaa-Pro-Dipeptidylaminopeptidase; T-Cell Activation Antigen CD26; Gly-Pro Naphthylamidase; Dipeptidyl Peptidase IV; Dipeptidyl-Peptidase IV; DPPIV; Dipeptidyl-Peptidase 4; Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing Protein 2); Dipeptidylpeptidase 4; ADCP-2; CD26 Antigen; Dipeptidyl Peptidase 4; ADABP
Species:
Human
Source:
HEK293
Cat. No.: HY-N8134
CAS No.: 1809980-25-3
Target:
Cat. No.: HY-117985S
Synonyms: DA-1229-d9
Cat. No.: HY-N9725
CAS No.: 141979-19-3
Synonyms: 16ξ-Hydroxycleroda-3,13-dien-15,16-olide
Target:
Research Areas:
16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD), a clerodane diterpene, is a potent serine protease dipeptidyl peptidase 4 (DPP-4) inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-induced ERK phosphorylation in myocyte but blocks GLP-1 induced PKA expression. 16-Hydroxycleroda-3,13-dien-15,16-olide exhibits hypolipidemic, hepatoprotective, hypoglycemic efficacy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
