141 Results for "

P2X Receptor

" in MedChemExpress (MCE) Product Catalog:
Products (141)

141 Results for "P2X Receptor" in MCE Product Catalog:

Boldine (Standard)
Boldine (Standard)
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Cat. No.: HY-N6973R
CAS No.: 476-70-0
Category:  

Alkaloids Lauraceae Extract Phenols Plants Disease Research Fields Inflammation/Immunology  Litsea cubeba (Lour.) Pers.

Target:  

Reference Standards Telomerase Gap Junction Protein P2X Receptor Calcium Channel Reactive Oxygen Species (ROS) NF-κB SGK TNF Receptor

Boldine (Standard) is the analytical standard of Boldine (HY-N6973). This product is intended for research and analytical applications. Boldine is an aporphine alkaloid telomerase (telomerase) inhibitor (IC50 of 0.17 μM for TERT) and a pannexin/connexin hemichannel blocker, with oral activity and blood-brain barrier permeability. Boldine inhibits telomerase activity through direct interaction with the telomerase ribonucleoprotein and non-competitive binding near the TERT active site, and downregulates hTERT mRNA while shifting alternative splicing toward non-functional transcripts. Boldine blocks Panx1, Cx43, Cx26, and Cx30 hemichannels as well as P2X7 receptor-mediated calcium influx. Boldine exhibits antioxidant, anti-inflammatory, antiproliferative, and cytotoxic activities by scavenging ROS, inhibiting NFκB, dephosphorylating SGK1, and reducing TNF-alpha levels. Boldine can be used in research on breast cancer, Alzheimer's disease, glioblastoma, diabetes, and spinal cord injury .
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