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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
160 Results for "
Pla2
" in MedChemExpress (MCE) Product Catalog:
Products (160)
160 Results for "Pla2" in MCE Product Catalog:
Cat. No.: HY-120078
CAS No.: 1845753-81-2
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AZD2716 is an orally active secretory phospholipase A2 (sPLA2) inhibitor. AZD2716 inhibits human GIIA sPLA2 (IC50=10 nM), human GV sPLA2 (IC50=40 nM), human GX sPLA2 (IC50=400 nM), snake venom sPLA2 (IC50=2 pM), and snake (Bothrops jararacussu) Lys49-PLA2-like toxin (Kd=110 μM). AZD2716 inhibits sPLA2 isoforms IIa, V, X, snake venom sPLA2s, and snake venom Lys49-PLA2-like toxin myotoxic activity via hydrophobic channel binding. AZD2716 suppresses GIIA sPLA2 production, neutralizes snake venom-induced myotoxicity, and improves survival in envenomed mice. AZD2716 can be used for the research of coronary artery disease, atherosclerosis, and snakebite envenoming [2] .
Cat. No.: HY-102004R
CAS No.: 412950-08-4
Synonyms: SB 659032 (Standard)
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Rilapladib (Standard) is the analytical standard of Rilapladib (HY-102004). This product is intended for research and analytical applications. Rilapladib (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM . Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist [2].
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DL-erythro-Dihydrosphingosine is a sphingosine-based PKC inhibitor. DL-erythro-Dihydrosphingosine directly inhibits the enzymatic activity of PLA2. DL-erythro-Dihydrosphingosine inhibits the activity of Bcl-2 protein involved in apoptosis. DL-erythro-Dihydrosphingosine inhibits the activity of matrix metalloproteinases (MMP). DL-erythro-Dihydrosphingosine is applicable for research on cancer and inflammatory diseases [2].
Cat. No.: HY-10521R
CAS No.: 356057-34-6
Synonyms: SB-480848 (Standard)
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Darapladib (Standard) is the analytical standard of Darapladib. This product is intended for research and analytical applications. Darapladib (SB-480848) is an orally active, selective and reversible Lp-PLA2 inhibitor (IC50=0.25 nM). Darapladib can trigger irreversible actions on glioma cell apoptosis and induce cycle arrest. Darapladib can be used in the study of atherosclerosis and cancer [2] .
Cat. No.: HY-P3906
CAS No.: 123168-46-7
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Cat. No.: HY-187095
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PTAD-ergosta-3-one is a snake venom enzyme inhibitor. PTAD-ergosta-3-one inhibits the procoagulant activity of citrated plasma mediated by serine protease (SVSP) from Bothrops asper venom. PTAD-ergosta-3-one inhibits the esterase activity of PLA2 from Bothrops asper venom. PTAD-ergosta-3-one can be used in the research of snakebite envenoming .
Cat. No.: HY-N16849
CAS No.: 145904-69-4
Synonyms: YM 26567-1
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Horsfieldia amygdalina (Wall. ex Hook. f. & Thomson) Warb. Coumarins Myristicaceae Phenylpropanoids Plants
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Cat. No.: HY-146925S
CAS No.: 2342574-95-0
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15:0 Lyso PC-d5 is deuterium labeled 15:0 Lyso PC (HY-W329357). 15:0 Lyso PC is a lysophosphatidylcholine (Lyso PC), a product of phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine (PC) and is involved in cell membrane remodeling and inflammatory signaling. 15:0 Lyso PC demonstrates significant lipid metabolism disturbances in the serum of patients with ischemic heart disease (IHD) and ischemic cardiomyopathy (ICM). 15:0 Lyso PC can be used as a lipid biomarker for cardiovascular disease.
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Glycerophospholipids and cephalins are a class of phospholipid compounds and important components of neural membranes. Glycerophospholipids and cephalins are hydrolysis substrates of phospholipase (such as PLA2, PLC, and PLD). After complete hydrolysis, they produce 1 mol of glycerol, phosphate, ethanolamine, and 2 mol of fatty acids, respectively. Glycerophospholipids and cephalins can maintain membrane structure, fluidity, and ion permeability, and serve as precursors of second messengers such as arachidonic acid and diacylglycerol. Glycerophospholipids and cephalins can regulate signal transduction, cell apoptosis, and membrane transport, and are used in the study of neurodegenerative diseases (such as Alzheimer's disease) [2].
Cat. No.: HY-N16865
Category:
Horsfieldia amygdalina (Wall. ex Hook. f. & Thomson) Warb. Coumarins Myristicaceae Phenylpropanoids Plants
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Cat. No.: HY-P990491
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YM-26734 is a competitive inhibitor of secretory phospholipase A 2 (PLA 2) that exhibits a broad inhibitory profile to several PLA2s .
Cat. No.: HY-P991428
Cat. No.: HY-P72293
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Pla2G15; 1-O-Acylceramide Synthase; Prev. LYPla3; LPla2; LLPL; ACS; GXVPla2; CDNA FLJ57757, Highly Similar To 1-O-Acylceramide Synthase; Lysophospholipase 3 (Lysosomal Phospholipase A2); CDNA FLJ58003, Highly Similar To 1-O-Acylceramide Synthase; Lysosoma
Species:
Mouse
Source:
E. coli
Cat. No.: HY-13402AR
CAS No.: 172733-42-5
Synonyms: LY315920 sodium (Standard)
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Varespladib (sodium) (Standard) is the analytical standard of Varespladib (sodium). This product is intended for research and analytical applications. Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .
Cat. No.: HY-13402R
CAS No.: 172732-68-2
Synonyms: LY315920 (Standard)
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Varespladib (Standard) is the analytical standard of Varespladib. This product is intended for research and analytical applications. Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .
Cat. No.: HY-116192
CAS No.: 150379-37-6
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CGP-43182 is a secretory phospholipase A2 group II (sPLA2) inhibitor with an IC50 of 2.8 μM. CGP-43182 binds to the active site of the enzyme, blocks IL1β-stimulated gene expression and NFκB activation, and inhibits the production of prostaglandin and nitric oxide (NO). CGP-43182 exhibits anti-inflammatory activity in multiple inflammatory models and can be used for studies on adjuvant arthritis, carrageenan-induced edema, pertussis pleurisy, and glomerular inflammatory responses [2] .
Cat. No.: HY-N21818
CAS No.: 172854-76-1
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Cat. No.: HY-P87025
Synonyms: Calcium dependent phospholipid binding protein antibody; CPla 2 antibody; cPla2 alpha antibody; cPla2 antibody; Cytosolic phospholipase A2 antibody; Cytosolic phospholipase A2 group IVA antibody; Lysophospholipase antibody; MGC126350 antibody; PA24A_HUMAN antibody; Phosphatidylcholine 2 acylhydrolase antibody; Calcium dependent phospholipid binding protein antibody; CPla 2 antibody; cPla2 alpha antibody; cPla2 antibody; Cytosolic phospholipase A2 antibody; Cytosolic phospholipase A2 group IVA antibody; Lysophospholipase antibody; MGC126350 antibody; PA24A_HUMAN antibody; Phosphatidylcholine 2 acylhydrolase antibody; Phosphatidylcholine 2-acylhydrolase antibody; Phospholipase A2 group 4 A antibody; Phospholipase A2 group IVA (cytosolic calcium dependent) antibody; Phospholipase A2 group IVA antibody; PhospholipaseA2 antibody; Pla2G4 antibody; Pla2g4a antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
