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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
200 Results for "
tissue factor
" in MedChemExpress (MCE) Product Catalog:
Products (200)
200 Results for "tissue factor" in MCE Product Catalog:
製品番号: HY-14863
CAS 番号: 250384-82-8
別名: CTA-018
Target:
研究分野:
Lunacalcipol (CTA-018), as a vitamin D analogue, has a dual role in the pathogenesis of Chronic Kidney Disease (CKD), as an agonist of vitamin D receptor and an antagonist of cytochrome P450 enzyme 24-hydroxylase. Lunacalcipol binds to VDR and regulates transcriptional activity of VDR by influencing ligand binding affinity, ligand-dependent coactivator recruitment or inhibitory factor dissociation, efficiency of ligand entry into target cells, tissue specificity and different metabolism of ligand. Lunacalcipol can be used in the study of CKD, especially Secondary Hyperparathyroidism (sHPT) .
製品番号: HY-187245A
別名: DSG-PEG2000-CSRNLIDC
Target:
研究分野:
DSG-PEG2000-pPB (DSG-PEG2000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: distearoylglycerol (DSG) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DSG-PEG2000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
製品番号: HY-187246
別名: DMG-PEG1000-CSRNLIDC
Target:
研究分野:
DMG-PEG1000-pPB (DMG-PEG1000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 1000 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DMG-PEG1000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
製品番号: HY-187246A
別名: DMG-PEG2000-CSRNLIDC
Target:
研究分野:
DMG-PEG2000-pPB (DMG-PEG2000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DMG-PEG2000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
製品番号: HY-187246B
別名: DMG-PEG3400-CSRNLIDC
Target:
研究分野:
DMG-PEG3400-pPB (DMG-PEG3400-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 3400 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DMG-PEG3400-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
製品番号: HY-187246C
別名: DMG-PEG5000-CSRNLIDC
Target:
研究分野:
DMG-PEG5000-pPB (DMG-PEG5000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 5000 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DMG-PEG5000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
製品番号: HY-187326
別名: DOPE-PEG1000-CSRNLIDC
Target:
研究分野:
DOPE-PEG1000-pPB (DOPE-PEG1000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 1000 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DOPE-PEG1000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
製品番号: HY-187326A
別名: DOPE-PEG2000-CSRNLIDC
Target:
研究分野:
DOPE-PEG2000-pPB (DOPE-PEG2000-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DOPE-PEG2000-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
製品番号: HY-187326B
別名: DOPE-PEG3400-CSRNLIDC
Target:
研究分野:
DOPE-PEG3400-pPB (DOPE-PEG3400-CSRNLIDC) is a functionalized PEGylated lipid conjugate composed of three modular components: dioleoylphosphatidylethanolamine (DOPE) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 3400 Da, and platelet-derived growth factor receptor β-binding peptide (pPB peptide (HY-P11549)) as the terminal targeting/functional ligand. DOPE-PEG3400-pPB enables targeted delivery to fibrotic tissues and tumor stroma.
製品番号: HY-L038
2,574 compounds
Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method.
MCE Differentiation Inducing Compound Library contains a unique collection of 2,574 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.
製品番号: HY-P70584
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: SERPINF1; Testis tissue Sperm-Binding Protein Li 70n; Prev. PEDF; Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived factor), Member 1; EPC-1; Proliferation-Inducing Protein 35; Pigment Epithelium-Derived factor; Serpin F
Species:
Mouse
Source:
E. coli
製品番号: HY-P74557
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: SERPINF1; Testis tissue Sperm-Binding Protein Li 70n; Prev. PEDF; Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived factor), Member 1; EPC-1; Proliferation-Inducing Protein 35; Pigment Epithelium-Derived factor; Serpin F
Species:
Rat
Source:
HEK293
製品番号: HY-19674
CAS 番号: 363151-21-7
別名: SSR182289A free base
Target:
研究分野:
SSR182289 (SSR182289A free base) is a selective and potent orally active thrombin inhibitor. SSR182289 competitively and selectivity inhibits human thrombin (Ki=0.031 μM). SSR182289 demonstrates anticoagulant activity in vitro (thrombin time EC100=96 nM) and inhibits tissue factor-induced thrombin generation (IC50=0.15 μM) in human plasma. SSR182289 inhibits thrombin-induced aggregation of human platelets (IC50=32 nM), but has no effect on aggregation induced by other platelet agonists .
製品番号: HY-P70498
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: SERPINF1; Testis tissue Sperm-Binding Protein Li 70n; Prev. PEDF; Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived factor), Member 1; EPC-1; Proliferation-Inducing Protein 35; Pigment Epithelium-Derived factor; Serpin F
Species:
Human
Source:
HEK293
製品番号: HY-164128
CAS 番号: 942296-18-6
AHL modulator-1 is a N-acylated L-homoserine lactone (AHL) modulator that modulating bacteria quorum sensing (QS). AHL modulator-1 can be used for the research of plant soft rot .
製品番号: HY-L045
4,317 compounds
Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.
HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O2 concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.
MCE offers a unique collection of 4,317 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.
製品番号: HY-162902
CAS 番号: 3001361-04-9
Target:
研究分野:
ALK5-IN-82 is a potent and selective inhibitor against activin receptor-like kinase 5 (ALK5) with an IC50 value of 9.1 nM. ALK5-IN-82 inhibits the protein expression of α-smooth muscle actin (α-SMA), collagen I and tissue inhibitor of metalloproteinase 1 (TIMP-1)/matrix metalloproteinase 13 (MMP-13) in transforming growth factor-β-induced human umbilical vein endothelial cells. ALK5-IN-82 is promising for research of cardiac fibrosis .
製品番号: HY-W016393R
CAS 番号: 2305-13-7
Category:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
