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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
238 Results for "
Diffuse
" in MedChemExpress (MCE) Product Catalog:
Products (238)
238 Results for "Diffuse" in MCE Product Catalog:
Cat. No.: HY-177750
CAS No.: 2417647-40-4
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TD-522 is a potent and selective molecular glue GSPT1 degrader, with a DC50 of 0.269 nM. TD-522 exhibits strong anti-proliferative effects and induces apoptosis in acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL) cells. TD-522 suppresses tumor growth in a TMD-8 xenograft model. TD-522 can be used for AML and DLBCL research .
Cat. No.: HY-187371
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DA29 is a human caseinolytic protease P (hClpP) activator, with an EC50 of 0.85 μM and a Kd of 185 nM. DA29 binds to the hydrophobic allosteric pocket of this enzyme, activates its proteolytic function, and displaces hClpX from the hClpXP complex. DA29 induces mitochondrial dysfunction and ROS accumulation. DA29 exerts cytotoxic effects on cancer cells and organoids. DA29 can be used in the research of diffuse intrinsic pontine glioma .
Cat. No.: HY-10293R
CAS No.: 791828-58-5
Synonyms: INCB007839 (Standard); INCB7839 (Standard)
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Aderbasib (Standard) is the analytical standard of Aderbasib (HY-10293). This product is intended for research and analytical applications. Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2+ breast cancer, gliomas, et al .
Cat. No.: HY-D3113
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BF6 is a blood-brain barrier permeable NIR probe. BF6 can diffuse from intracranial blood vessels into brain tissue, enabling visualization of brain structures and differentiation between glioblastoma (GBM) and normal tissues. The absorption peaks of BF6 in DMSO and FBS range from 727 to 859 nm, with a broad fluorescence emission band spanning 800 to 1400 nm; its emission wavelength falls within the NIR-II region (800-1400 nm) .
Cat. No.: HY-W703549
Synonyms: INCB007839-d3; INCB7839-d3
Cat. No.: HY-173097
CAS No.: 2086298-33-9
Synonyms: VH032-Boc derivative 1
Research Areas:
(S,R,S)-AHPC-Boc derivative 1 (VH032-Boc derivative 1) is a derivative of (S,R,S)-AHPC-Boc (HY-123109), which is applicable to research related to PROTAC synthesis .
Cat. No.: HY-W1115268
CAS No.: 3043925-99-8
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E3 Ligase Ligand-linker Conjugate 231 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 231 can be used for the synthesis of the PROTAC BRD9 Degrader-8 (HY-162651) .
Cat. No.: HY-117622
CAS No.: 1388894-17-4
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ND-2110 is a selective IRAK4 inhibitor (Ki: 7.5 nM). ND-2110 binds to the ATP pocket of IRAK4. ND-2110 targets
the subset of activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL) cell lines with MYD88 L265P mutations,. ND-2110 inhibits LPS-induced TNF production, alleviates collagen-induced arthritis, and blocks gout formation in mouse models .
PROTAC BTK Degrader-1 is a selective, orally active BTK PROTAC degrader with a DC50 of 5.8 nM. PROTAC BTK Degrader-1 induces ubiquitination and degradation of wild-type and mutant (C481S, T316) BTK proteins via the CRBN-mediated pathway. PROTAC BTK Degrader-1 exhibits anticancer activity against diffuse large B-cell lymphoma. PROTAC BTK Degrader-1 can be used in lymphoma-related research .
Cat. No.: HY-150268
CAS No.: 2089390-09-8
Synonyms: OPN-2853; PLX2853; BET-IN-16
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Zavabresib (OPN-2853; PLX2853; BET-IN-16) is an orally active inhibitor of the BET family of proteins. Zavabresib blocks bromodomain-mediated interactions, reduces BRD4 enrichment at the regulatory regions of transcription factors in T cells, exerts tumor growth inhibitory effects, and enhances the efficacy of immunotherapy. Zavabresib is applicable to research on chronic lymphocytic leukemia, castration-resistant prostate cancer, diffuse large B-cell lymphoma, colon adenocarcinoma, and myelofibrosis .
Cat. No.: HY-162624
Quorum sensing-IN-5 is a RpfF-targeted quorum-sensing inhibitor. Quorum sensing-IN-5 inhibits Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac) with EC50 values of 9.91 μg/mL and 7.04 μg/mL. Quorum sensing-IN-5 has antimicrobial activity .
Cat. No.: HY-13637B
CAS No.: 1359968-33-4
Synonyms: BW-759 hydrate; 2'-Nor-2'-deoxyguanosine hydrate
Ganciclovir (BW 759) hydrate, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir hydrate also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir hydrate inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir hydrate has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain .
Cat. No.: HY-181084
CAS No.: 3039500-55-2
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PROTAC BCL6/GSPT1 Degrader-1 is a dual-target PROTAC degrader that targets BCL6 and GSPT1. PROTAC BCL6/GSPT1 Degrader-1 inhibits cell proliferation, promotes DNA damage, and induces cell cycle arrest and apoptosis in diffuse large B-cell lymphoma. PROTAC BCL6/GSPT1 Degrader-1 can be used for research on tumors such as lymphoma .
Cat. No.: HY-189422
CDK9/EZH2-IN-2 is a potent dual CDK9 and EZH2 inhibitor with an IC50 of 8.9 nM against EZH2. CDK9/EZH2-IN-2 inhibits anti-apoptotic proteins and induces DNA damage by blocking the activity of CDK9 and EZH2, ultimately leading to tumor cell apoptosis. CDK9/EZH2-IN-2 can be used for research on diffuse large B-cell lymphoma .
Cat. No.: HY-100507A
CAS No.: 1398053-45-6
Synonyms: CC 122 hydrochloride
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Avadomide hydrochloride (CC 122 hydrochloride) is the hydrochloride form of Avadomide (HY-100507). Avadomide hydrochloride is an orally active cereblon modulator. Avadomide hydrochloride modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide hydrochloride exhibits potent antitumor and immunomodulatory activities .
Cat. No.: HY-100507R
CAS No.: 1015474-32-4
Synonyms: CC 122 (Standard)
Research Areas:
Avadomide (Standard) is the analytical standard of Avadomide. This product is intended for research and analytical applications. Avadomide is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities .
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IRAK4-IN-7 is a selective, potent and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, extracted from patent WO2015104688 (example 1). IRAK4-IN-7 has the potential for cancer and inflammatory diseases treatment .
Cat. No.: HY-109585R
CAS No.: 1801343-74-7
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IRAK4-IN-7 (Standard) is the analytical standard of IRAK4-IN-7 (HY-109585). This product is intended for research and analytical applications. IRAK4-IN-7 is a selective, potent and orally active interleuKin-1 receptor-associated Kinase 4 (IRAK4) inhibitor, extracted from patent WO2015104688 (example 1). IRAK4-IN-7 has the potential for cancer and inflammatory diseases treatment .
Synonyms: HMSL 10017-101-1
HG6-64-1 (HMSL 10017-101-1) is a B-raf kinase modulator.HG6-64-1 modulates B-raf kinase activity, including the V600E mutant form and the drug-resistant gatekeeper mutation T529I. HG6-64-1 is a germinal center kinase inhibitor. HG6-64-1 induces cell cycle arrest and apoptosis. HG6-64-1 can be used for the research of diffuse large B-cell lymphoma (DLBCL) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
