(S,R,S)-AHPC-Boc derivative 1
Based on 1 Customer Validation
(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1, leading to ubiquitination and subsequent proteasomal degradation of MALT1. (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway by disrupting the CBM complex, demonstrating potential for inducing apoptosis in ABC-DLBCL cells. (S,R,S)-AHPC-Boc derivative 1 is promising for research of MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).
For research use only. We do not sell to patients.
- Purity: 98.56%
- CAS No.: 2086298-33-9
- Formula: C28H40N4O6S
- Molecular Weight:560.71
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2086298-33-9
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Appearance Solid
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Molecular Weight 560.71
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Formula C28H40N4O6S
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Color White to off-white
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SMILES
CC(C)(C)OC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)CO)=O)=O)=O
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Synonyms
VH032-Boc derivative 1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (89.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7835 mL | 8.9173 mL | 17.8345 mL | 44.5863 mL |
| 5 mM | 0.3567 mL | 1.7835 mL | 3.5669 mL | 8.9173 mL | |
| 10 mM | 0.1783 mL | 0.8917 mL | 1.7835 mL | 4.4586 mL | |
| 15 mM | 0.1189 mL | 0.5945 mL | 1.1890 mL | 2.9724 mL | |
| 20 mM | 0.0892 mL | 0.4459 mL | 0.8917 mL | 2.2293 mL | |
| 25 mM | 0.0713 mL | 0.3567 mL | 0.7134 mL | 1.7835 mL | |
| 30 mM | 0.0594 mL | 0.2972 mL | 0.5945 mL | 1.4862 mL | |
| 40 mM | 0.0446 mL | 0.2229 mL | 0.4459 mL | 1.1147 mL | |
| 50 mM | 0.0357 mL | 0.1783 mL | 0.3567 mL | 0.8917 mL | |
| 60 mM | 0.0297 mL | 0.1486 mL | 0.2972 mL | 0.7431 mL | |
| 80 mM | 0.0223 mL | 0.1115 mL | 0.2229 mL | 0.5573 mL |
(S,R,S)-AHPC-Boc derivative 1 Related Classifications
HY-173097 Related Classifications
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