Avadomide hydrochloride
Based on 6 publication(s) in Google Scholar
Avadomide hydrochloride (CC 122 hydrochloride) is the hydrochloride form of Avadomide (HY-100507). Avadomide hydrochloride is an orally active cereblon modulator. Avadomide hydrochloride modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide hydrochloride exhibits potent antitumor and immunomodulatory activities.
For research use only. We do not sell to patients.
- CAS No.: 1398053-45-6
- Formula: C14H15ClN4O3
- Molecular Weight:322.75
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Avadomide hydrochloride
More- Nat Commun. 2020 Jul 14;11(1):3508. [Abstract]
- Cell Rep Med. 2024 Mar 19;5(3):101472. [Abstract]
- Cell Chem Biol. 2020 Jul 16;27(7):866-876.e8. [Abstract]
- iScience. 2023 Jun 7;26(7):107059. [Abstract]
- J Dermatol Sci. 2025 Sep 26:S0923-1811(25)00177-X. [Abstract]
- Cancer Chemother Pharmacol. 2023 Oct;92(4):303-314. [Abstract]
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Biological Activity
Chemical Information
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CAS No. 1398053-45-6
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Molecular Weight 322.75
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Formula C14H15ClN4O3
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SMILES
O=C(N1)C(CCC1=O)N2C(C)=NC3=C(C2=O)C(N)=CC=C3.[H]Cl
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Synonyms
CC 122 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Nat Commun
2020 Jul 14;11(1):3508. PMID: 32665554 -
Cell Rep Med
STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma. [Abstract]2024 Mar 19;5(3):101472. PMID: 38508140 -
Cell Chem Biol
A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders. [Abstract]2020 Jul 16;27(7):866-876.e8. PMID: 32413286 -
iScience
iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells. [Abstract]2023 Jun 7;26(7):107059. PMID: 37360684 -
J Dermatol Sci
Regulation of melanogenesis via ubiquitin-proteasome system and autophagy by 3,3,5-trimethylcyclohexyl succinate dimethylamide and tranexamic acid. [Abstract]2025 Sep 26:S0923-1811(25)00177-X. PMID: 41046159 -
Cancer Chemother Pharmacol
Anti-tumor effect of avadomide in gemcitabine-resistant pancreatic ductal adenocarcinoma. [Abstract]2023 Oct;92(4):303-314. PMID: 37491611
Avadomide hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Chemother Pharmacol. 2023 Oct;92(4):303-314. [Abstract]
MTT assay showing the anti-tumor effects of Avadomide in four PDAC cell lines. Data are represented as mean of triplicate independent experiments.
Avadomide hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Chemother Pharmacol. 2023 Oct;92(4):303-314. [Abstract]
Representative dot plots from flow cytometry analysis illustrating apoptotic status by Annexin V assay. Panc1, BcPX3, and PSN1 after treatment with placebo, 10 ng/mL gemcitabine, and 200 μM avadomide for 36 h, respectively.
Avadomide hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Chemother Pharmacol. 2023 Oct;92(4):303-314. [Abstract]
The effect of Avadomide (200 μM; 36 h) on the protein levels of pIκBα and IκBα in PDAC cells.
Avadomide hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Chemother Pharmacol. 2023 Oct;92(4):303-314. [Abstract]
Avadomide (0.5 mg/kg). Tumor growth rates varied among different cell lines. MiaPaCa2-GR2 showed the strongest inhibitory effect.
Avadomide hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Chemother Pharmacol. 2023 Oct;92(4):303-314. [Abstract]
Avadomide (0.5 mg/kg). Hematoxylin-eosin staining of tumor tissue.
Purity & Documentation
References
[1]. Rasco DW, et al. A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies. Clin Cancer Res. 2019 Jan 1;25(1):90-98. [Content Brief]
[2]. Hagner, P.R.et al.CC-122, a pleiotropic pathway modifier, mimics an IFN response and has antitumor activity in DLBCL.Blood.Aug 6;126(6):779-89. [Content Brief]
[3]. Nishi H, et al., Anti-tumor effect of avadomide in gemcitabine-resistant pancreatic ductal adenocarcinoma. Cancer Chemother Pharmacol. 2023 Oct;92(4):303-314. [Content Brief]
Calculators
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