1015474-32-4
1015474-32-4
Chemical Structure
Avadomide
Synonym(s): CC 122
- CAS No.: 1015474-32-4
- Formula:C14H14N4O3
- Molecular Weight:286.29
IUPAC Name: 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione
InChIKey: RSNPAKAFCAAMBH-UHFFFAOYSA-N
SMILES: O=C(C(N1C(C)=NC2=C(C(N)=CC=C2)C1=O)CC3)NC3=O
Biological Activity: Avadomide is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities[1][2][3].
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Avadomide | 99.56% | Avadomide is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities. | ||||||||||||||||||||
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Avadomide (Standard) | ≥98% | Avadomide (Standard) is the analytical standard of Avadomide. This product is intended for research and analytical applications. Avadomide is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-100507AAvadomide hydrochloride -
Similarity Score 0.80
HY-W797335CRBN ligand-200 -
Similarity Score 0.76
HY-W865379(S)-Avadomide-d1 -
Similarity Score 0.72
HY-114406TD-106 -
Similarity Score 0.65
HY-W580117CRBN ligand-788 -
Similarity Score 0.63
HY-W999669Hydrouracil-4-benzazimide-7-NH2 -
Similarity Score 0.63
HY-45512E3 ligase Ligand 63 -
Similarity Score 0.63
HY-163927E3 ligase Ligand 29 -
Similarity Score 0.62
HY-W998276CRBN ligand-796 -
Explore the MedChemAI to find more analogs
References
- [1]. Rasco DW, et al. A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies. Clin Cancer Res. 2019 Jan 1;25(1):90-98. [Content Brief]
- [2]. Hagner, P.R.et al.CC-122, a pleiotropic pathway modifier, mimics an IFN response and has antitumor activity in DLBCL.Blood.Aug 6;126(6):779-89. [Content Brief]
- [3]. Nishi H, et al., Anti-tumor effect of avadomide in gemcitabine-resistant pancreatic ductal adenocarcinoma. Cancer Chemother Pharmacol. 2023 Oct;92(4):303-314. [Content Brief]
