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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
(S)-GNE-140 (Standard)
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "(S)-GNE-140 (Standard)" in MCE Product Catalog:
Cat. No.: HY-100742BR
CAS No.: 2003234-64-6
Research Areas:
(S)-GNE-140 Standard is the analytical standard of (S)-GNE-140 (HY-100742B). This product is intended for research and analytical applications. (S)-GNE-140 (Compound 30-S) is the S enantiomer of GNE-140 (HY-118241). (S)-GNE-140 is a potent inhibitor of human LDHA and LDHB, with IC50 values of 55 nM and 140 nM, respectively. (S)-GNE-140 exerts its inhibitory effect by non-competitively binding to NADH and occupying the LDH pyruvate site, but its activity is weaker than that of the R enantiomer. (S)-GNE-140 can be used for cancer research .
Cat. No.: HY-100742R
CAS No.: 1802977-61-2
GNE-140 racemate (Standard) is the analytical standard of GNE-140 racemate (HY-100742). This product is intended for research and analytical applications. GNE-140 racemate is a racemic mixture of (R)-GNE-140 (HY-100742A) and (S)-GNE-140 (HY-100742B), and also a tautomer of GNE-140 (HY-118241). GNE-140 racemate is an orally active lactate dehydrogenase inhibitor, with an IC50 of 3 nM against human LDHA and an IC50 of 5 nM against LDHB. GNE-140 racemate reduces the phosphorylation level and total protein expression of p38 MAPK, and inhibits EGF-induced AKT phosphorylation. GNE-140 racemate decreases lactate production, regulates glycolysis, the pentose phosphate pathway and nucleotide biosynthesis, increases extracellular pH, inhibits cell proliferation, migration and invasion, and induces caspase-3 activation and ROS accumulation. GNE-140 racemate can be used in research related to breast cancer, cystic fibrosis and pancreatic cancer .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
