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α-Hydroxyisocaproic acid

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By Targets:	Amino Acid Derivatives (2) AMPK (1) Drug Metabolite (1) Endogenous Metabolite (3) ERK (1) Hydroxycarboxylic Acid Receptor (HCAR) (1) Isotope-Labeled Compounds (1) Reference Standards (2)
By Research Areas:	Inflammation/Immunology (1) Metabolic Disease (3)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-30216A

Leucic acid α-Hydroxyisocaproic acid	Drug Metabolite Hydroxycarboxylic Acid Receptor (HCAR) AMPK ERK	Metabolic Disease Inflammation/Immunology
Leucic acid (α-Hydroxyisocaproic acid) is an orally active end-product of the microbial metabolism of leucine. Leucic acid can bind to HCAR2, alters AMPK and ERK1/2 phosphorylation status, suppresses lipid synthesis, promotes catabolism, reduces adiposity, enhances lean mass and exercise capacity. Leucic acid suppresses pro-inflammatory cytokine secretion, inflammation-related gene mRNA expression. Leucic acid decreases basal protein synthesis, attenuates myotube atrophy. Leucic acid can be used for the research of obesity .

HY-30216

(R)-Leucic acid D-α-Hydroxyisocaproic acid	Amino Acid Derivatives Endogenous Metabolite	Metabolic Disease
(R)-Leucic acid (D-α-Hydroxyisocaproic acid) is an orally active D-isomer of the α-hydroxy analogue of Leucine (HY-N0486). (R)-Leucic acid is a metabolite of Lactobacillus and can promote intestinal fatty acid absorption by upregulating CD36 expression. (R)-Leucic acid can be used to study microbe-host interactions and the regulation of lipid metabolism by probiotics .

HY-30216AR

Leucic acid (Standard) α-Hydroxyisocaproic acid (Standard)	Endogenous Metabolite Reference Standards	Others
Leucic acid (Standard) is the analytical standard of Leucic acid. This product is intended for research and analytical applications. Leucic acid is an amino acid metabolite .

HY-30216AS

Leucic acid-13C α-Hydroxyisocaproic acid-¹³C	Isotope-Labeled Compounds	Others
Leucic acid- ¹³C (α-Hydroxyisocaproic acid- ¹³C) is the ¹³C-labeled Leucic acid (HY-30216A). Leucic acid is an amino acid metabolite .

HY-30216R

(R)-Leucic acid (Standard) D-α-Hydroxyisocaproic acid (Standard)	Reference Standards Amino Acid Derivatives Endogenous Metabolite	Metabolic Disease
(R)-Leucic acid (Standard) is the analytical standard of (R)-Leucic acid (HY-30216). This product is intended for research and analytical applications. (R)-Leucic acid (D-α-Hydroxyisocaproic acid) is the D-isomer of the α-hydroxy analogue of Leucine (HY-N0486). (R)-Leucic acid is a metabolite of Lactobacillus and can promote intestinal fatty acid absorption by upregulating CD36 expression. (R)-Leucic acid can be used to study microbe-host interactions and the regulation of lipid metabolism by probiotics.

Cat. No.	Product Name	Target	Research Area

HY-30216A

Leucic acid α-Hydroxyisocaproic acid	Drug Metabolite Hydroxycarboxylic Acid Receptor (HCAR) AMPK ERK	Metabolic Disease Inflammation/Immunology
Leucic acid (α-Hydroxyisocaproic acid) is an orally active end-product of the microbial metabolism of leucine. Leucic acid can bind to HCAR2, alters AMPK and ERK1/2 phosphorylation status, suppresses lipid synthesis, promotes catabolism, reduces adiposity, enhances lean mass and exercise capacity. Leucic acid suppresses pro-inflammatory cytokine secretion, inflammation-related gene mRNA expression. Leucic acid decreases basal protein synthesis, attenuates myotube atrophy. Leucic acid can be used for the research of obesity .

HY-30216AR

Leucic acid (Standard) α-Hydroxyisocaproic acid (Standard)	Endogenous Metabolite Reference Standards	Others
Leucic acid (Standard) is the analytical standard of Leucic acid. This product is intended for research and analytical applications. Leucic acid is an amino acid metabolite .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-30216A

Leucic acid α-Hydroxyisocaproic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Hydroxycarboxylic Acid Receptor (HCAR) AMPK ERK
Leucic acid (α-Hydroxyisocaproic acid) is an orally active end-product of the microbial metabolism of leucine. Leucic acid can bind to HCAR2, alters AMPK and ERK1/2 phosphorylation status, suppresses lipid synthesis, promotes catabolism, reduces adiposity, enhances lean mass and exercise capacity. Leucic acid suppresses pro-inflammatory cytokine secretion, inflammation-related gene mRNA expression. Leucic acid decreases basal protein synthesis, attenuates myotube atrophy. Leucic acid can be used for the research of obesity .

HY-30216

(R)-Leucic acid D-α-Hydroxyisocaproic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Amino Acid Derivatives Endogenous Metabolite
(R)-Leucic acid (D-α-Hydroxyisocaproic acid) is an orally active D-isomer of the α-hydroxy analogue of Leucine (HY-N0486). (R)-Leucic acid is a metabolite of Lactobacillus and can promote intestinal fatty acid absorption by upregulating CD36 expression. (R)-Leucic acid can be used to study microbe-host interactions and the regulation of lipid metabolism by probiotics .

HY-30216AR

Leucic acid (Standard) α-Hydroxyisocaproic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Leucic acid (Standard) is the analytical standard of Leucic acid. This product is intended for research and analytical applications. Leucic acid is an amino acid metabolite .

HY-30216R

(R)-Leucic acid (Standard) D-α-Hydroxyisocaproic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Amino Acid Derivatives Endogenous Metabolite
(R)-Leucic acid (Standard) is the analytical standard of (R)-Leucic acid (HY-30216). This product is intended for research and analytical applications. (R)-Leucic acid (D-α-Hydroxyisocaproic acid) is the D-isomer of the α-hydroxy analogue of Leucine (HY-N0486). (R)-Leucic acid is a metabolite of Lactobacillus and can promote intestinal fatty acid absorption by upregulating CD36 expression. (R)-Leucic acid can be used to study microbe-host interactions and the regulation of lipid metabolism by probiotics.

Cat. No.	Product Name	Chemical Structure

HY-30216AS

Leucic acid-13C
Leucic acid- ¹³C (α-Hydroxyisocaproic acid- ¹³C) is the ¹³C-labeled Leucic acid (HY-30216A). Leucic acid is an amino acid metabolite .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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α-Hydroxyisocaproic acid

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products