498-36-2
Chemical Structure
Leucic acid
Synonym(s): α-Hydroxyisocaproic acid
- CAS No.: 498-36-2
- Formula:C6H12O3
- Molecular Weight:132.16
IUPAC Name: 2-hydroxy-4-methylpentanoic acid
InChIKey: LVRFTAZAXQPQHI-UHFFFAOYSA-N
SMILES: CC(C)CC(O)C(O)=O
Biological Activity: Leucic acid (α-Hydroxyisocaproic acid) is an orally active end-product of the microbial metabolism of leucine. Leucic acid can bind to HCAR2, alters AMPK and ERK1/2 phosphorylation status, suppresses lipid synthesis, promotes catabolism, reduces adiposity, enhances lean mass and exercise capacity. Leucic acid suppresses pro-inflammatory cytokine secretion, inflammation-related gene mRNA expression. Leucic acid decreases basal protein synthesis, attenuates myotube atrophy. Leucic acid can be used for the research of obesity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Leucic acid | 98.38% | Leucic acid (α-Hydroxyisocaproic acid) is an orally active end-product of the microbial metabolism of leucine. Leucic acid can bind to HCAR2, alters AMPK and ERK1/2 phosphorylation status, suppresses lipid synthesis, promotes catabolism, reduces adiposity, enhances lean mass and exercise capacity. Leucic acid suppresses pro-inflammatory cytokine secretion, inflammation-related gene mRNA expression. Leucic acid decreases basal protein synthesis, attenuates myotube atrophy. Leucic acid can be used for the research of obesity. | ||||||||||||||||||||
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Leucic acid (Standard) | 98.64% | Leucic acid (Standard) is the analytical standard of Leucic acid. This product is intended for research and analytical applications. Leucic acid is an amino acid metabolite. | ||||||||||||||||||||
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Leucic acid-13C | Leucic acid-13C (α-Hydroxyisocaproic acid-13C) is the 13C-labeled Leucic acid (HY-30216A). Leucic acid is an amino acid metabolite. | |||||||||||||||||||||
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- [1]. Lin S Y, et al. Gut bacteria enriched in obese mice produce leucic acid to counter obesity through HCAR2[J]. 2025.
- [2]. Lee M, et al. Metabolites of Kimchi Lactic Acid Bacteria, Indole-3-Lactic Acid, Phenyllactic Acid, and Leucic Acid, Inhibit Obesity-Related Inflammation in Human Mesenchymal Stem Cells. J Microbiol Biotechnol. 2024;34(2):306-313. [Content Brief]
- [3]. Sumi K, et al. α-Hydroxyisocaproic Acid Decreases Protein Synthesis but Attenuates TNFα/IFNγ Co-Exposure-Induced Protein Degradation and Myotube Atrophy via Suppression of iNOS and IL-6 in Murine C2C12 Myotube. Nutrients. 2021 Jul 13;13(7):2391. [Content Brief]
