17 Results for "

α-Mannosidase

" in MedChemExpress (MCE) Product Catalog:
Products (17)

17 Results for "α-Mannosidase" in MCE Product Catalog:

Cat. No.: HY-P2950
CAS No.: 9025-42-7
Target:  

Glycosidase

Research Areas:  

Metabolic Disease

α-Mannosidase is a hydrolytic enzyme targeting mannose-containing glycoproteins or glycolipids. α-Mannosidase is promising for research of inherited α-mannosidosis .
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17
17 Cited Publications
Cat. No.: HY-19332
CAS No.: 109944-15-2
Synonyms: FR-900494
Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .
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1 Cited Publications
Cat. No.: HY-N6722
CAS No.: 72741-87-8
Synonyms: Tridolgosir
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity .
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Cat. No.: HY-N1470
CAS No.: 78708-33-5
Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC50 values of 5 μM and a Ki of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .
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Cat. No.: HY-E70185
Synonyms: EC:3.2.1.24; MAN2B1; LAMAN
Lysosomal α-mannosidase (EC:3.2.1.24) is a low pH-activated exoglycosidase that hydrolyzes α-mannosidic linkages on mannan and N-linked oligosaccharides, and its activation requires Zn 2+. As the major exoglycosidase in the glycoprotein degradation pathway, lysosomal α-mannosidase cleaves α1,2-, α1,3- and α1,6-mannosidic linkages during a non-random, ordered degradation process to generate Man1GlcNAc1-2 for further lysosomal processing. Lysosomal α-mannosidase can be used in studies related to α-mannosidosis .
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Cat. No.: HY-W357151
CAS No.: 425427-88-9
6-Chloro-3-indoxyl-α-D-mannopyranoside is a chromogenic substrate for α-mannosidase resulting in a salmon colored precipitate upon cleavage.
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Cat. No.: HY-E70304
CAS No.: 1505450-17-8
Synonyms: MAN1A1
Target:  

Glycosidase

Research Areas:  

Others

Mannosyl-oligosaccharide 1,2-α-mannosidase IA (MAN1A1) is a glycosidase that catalyzes the hydrolysis of α-1,2-linked mannose residues in Man(9)GlcNAc(2) to produce Man(9)GlcNAc(2) .
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Cat. No.: HY-P2950K
CAS No.: 9025-42-7
Research Areas:  

Others

exo-α-Mannosidase, Bacteroides thetaiotaomicron (EC.3.2.1.24) is a glycoside hydrolase involved in mannan decomposition .
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Cat. No.: HY-181175
CAS No.: 1531606-19-5
Target:  

Glycosidase

Research Areas:  

Metabolic Disease

OMJ-4 is a mutant alpha-mannosidase modulator. OMJ-4 can restore mutant alpha-mannosidase's catalytic function, and induces changes in compactness and active-site flexibility to improve substrate accommodation. OMJ-4 acts as an inducer of substrate reactivity, increasing the reactivity of mannose disaccharide bound to mutant alpha-mannosidase. OMJ-4 reduces the activation energy required for the enzymatic reaction of mutant alpha-mannosidase. OMJ-4 can be used for the research of alpha-mannosidosis .
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Cat. No.: HY-P86954
Synonyms: 3-1 antibody; 6-alpha-Mannosidase antibody; Alpha Mannosidase 2 antibody; alpha Mannosidase II antibody; Alpha-Mannosidase 2 antibody; AMAN II antibody; Golgi alpha Mannosidase II antibody; Golgi alpha-Mannosidase II antibody; Golgi integral membrane protein 7 antibody; GOLIM7 antibody; 3-1 antibody; 6-alpha-Mannosidase antibody; Alpha Mannosidase 2 antibody; alpha Mannosidase II antibody; Alpha-Mannosidase 2 antibody; AMAN II antibody; Golgi alpha Mannosidase II antibody; Golgi alpha-Mannosidase II antibody; Golgi integral membrane protein 7 antibody; GOLIM7 antibody; MA2A1_HUMAN antibody; MAN II antibody; Man2a1 antibody; MANA 2 antibody; MANA2 antibody; MANII antibody; Mann II antibody; Mannosidase alpha class 2A member 1 antibody; Mannosidase Two antibody; Mannosidase, alpha type II antibody; Mannosidase, alpha, II antibody; Mannosyl oligosaccharide 1 3 1 6 alpha Mannosidase antibody; Mannosyl oligosaccharide 1,3 1,6 alpha Mannosidase antibody; Mannosyl-oligosaccharide 1 antibody;

Host:  

Rabbit

Application:  

WB, IHC-P, FC

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-179631
Target:  

Apoptosis

Research Areas:  

Cancer

2DG-ODDA is a 2-deoxyglucose (2-DG) (HY-13966) derivative with potent antitumor activity. 2DG-ODDA induces apoptosis, and reduces ATP production. 2DG-ODDA is taken up through both fatty acid and glucose transporters and is cleaved by α-Mannosidase (HY-P2950), releases 2DG to inhibit N-glycosylation and disrupt cellular metabolism. 2DG-ODDA inhibits tumor growth in a 4T1 mouse model. 2DG-ODDA can be used for the research of triple-negative breast cancer (TNBC) .
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Cat. No.: HY-N1470R
CAS No.: 78708-33-5
Plantagoside (Standard) is the analytical standard of Plantagoside (HY-N1470). This product is intended for research and analytical applications. Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC50 values of 5 μM and a Ki of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .
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Cat. No.: HY-P70957
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAN1B1; Endoplasmic Reticulum Class I Alpha-Mannosidase; Mannosidase Alpha Class 1B Member 1; ER Alpha 1,2-Mannosidase; ERMan1; Man9GlcNAc2-Specific-Processing Alpha-Mannosidase; MANA-ER; Endoplasmic Reticulum Alpha-Mannosidase 1; ERManI; Mannosidase, Alp
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-D3187
CAS No.: 2484831-02-7
HMRef-αMan is a substrate-based green fluorescent probe (Ex/Em=465 nm/515 nm) targeting MAN2C1 (α-mannosidase). HMRef-αMan can be specifically cleaved by MAN2C1 to generate a highly fluorescent product, which thus gets activated to produce green fluorescence in malignant breast tissues, benign lesions and living cancer cells. The signal intensity of HMRef-αMan is directly correlated with MAN2C1 activity, and it can effectively detect tiny breast cancer lesions with a diameter of less than 1 mm. When used in combination with the red-emitting γ-glutamyl transpeptidase (GGT) probe gGlu-2OMe SiR600 (HY-D3188), HMRef-αMan enables precise optical differentiation of breast tissue types via a dual-color imaging strategy. HMRef-αMan has been widely used in the research of breast diseases such as breast cancer, fibroadenoma, phyllodes tumor and various types of papilloma .
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Cat. No.: HY-P76897
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EDEM2; ER Degradation Enhancer, Mannosidase Alpha-Like 2; Prev. C20orf31; ER Degradation-Enhancing-Mannosidase-Like Protein 2; Prev. C20orf49; ER Degradation-Enhancing Alpha-Mannosidase-Like 2; BA4204.1; Chromosome 20 Open Reading Frame 31; ER Degradation
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P76485
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAN1A2; Alpha-1,2-Mannosidase IB; Mannosidase Alpha Class 1A Member 2; Mannosidase, Alpha, Class 1A, Member 2; MAN1B; Alpha-1,2-Mannosidase; Mannosyl-Oligosaccharide 1,2-Alpha-Mannosidase IB; Alpha1,2-Mannosidase; Processing Alpha-1,2-Mannosidase IB
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-D3188
CAS No.: 2730023-28-4
gGlu-2OMe SiR600 is a γ-glutamyl transpeptidase (GGT) responsive fluorescent probe. gGlu-2OMe SiR600 can be converted into a highly fluorescent molecule via reaction with GGT, and its initial fluorescence is quenched through a photoinduced electron transfer (PeT) mechanism. gGlu-2OMe SiR600 exhibits fluorescence activation in malignant breast cancer and benign breast fibroadenoma tissues, enabling lesion visualization. gGlu-2OMe SiR600 can be used for research related to breast cancer and fibroadenoma .
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