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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
α-helix
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "α-helix" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P2080B
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1
1 Cited Publications
Cat. No.: HY-P2294A
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1
Cat. No.: HY-P5423
CAS No.: 107658-43-5
Cat. No.: HY-P0311
CAS No.: 184776-51-0
Cat. No.: HY-P5726
CAS No.: 302343-01-7
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Cat. No.: HY-W006886
CAS No.: 945212-26-0
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Cat. No.: HY-W028350
CAS No.: 40106-12-5
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NSC727447 is a vinyl urea-based allosteric inhibitor of HIV reverse transcriptase-associated RNase H with IC50 values of 2.0 μM and 2.5 μM against HIV-1 and HIV-2 RNase H, respectively, and IC50 values of 100 μM and 10.6 μM against Escherichia coli and human RNase H, respectively. NSC727447 exerts allosteric inhibitory effects mainly by interacting with the region adjacent to α-helix I in the thumb subdomain of the p51 subunit of HIV-1 reverse transcriptase. Cys280, Lys281 and the RNase H primer grip region are involved in its action, and it may inhibit the catalytic activity of RNase H by altering the positioning of nucleic acid substrates or the geometry of the RNase H active site. NSC727447 can be used in studies related to HIV infection, the function of HIV reverse transcriptase RNase H, and allosteric inhibition mechanisms .
Cat. No.: HY-P1341
CAS No.: 343268-91-7
Synonyms: Orexin A (17-33) (human, mouse, rat, bovine)
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Cat. No.: HY-P0311A
Cat. No.: HY-P4118
CAS No.: 952754-66-4
Synonyms: Penetrating analog
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Pyridin-3-ylboronic acid is a synthetic building block belonging to the pyridine boronic acid class. Pyridin-3-ylboronic acid serves as a substrate for the Suzuki-Miyaura coupling reaction to construct oligopyridine backbones. Pyridin-3-ylboronic acid also acts as a heteroaryl boronic acid in the phosphine-free Suzuki-Miyaura coupling reaction of 2-iodogalactal. Pyridin-3-ylboronic acid is applicable to research related to organic synthesis .
Cat. No.: HY-P4119
CAS No.: 863608-35-9
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Cat. No.: HY-P5917A
Synonyms: Vaejovis mexicanus peptide 24 TFA
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Cat. No.: HY-P10319
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Cat. No.: HY-P2080
CAS No.: 198624-01-0
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Cat. No.: HY-P3916
CAS No.: 136831-50-0
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Cat. No.: HY-P2294
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Cat. No.: HY-168886
Anticancer agent 263 (compound 7) is a potent anticancer agent. Anticancer agent 263 binds to the G-quadruplex DNA (G4) sequence 22-mer Pu22, a mimic of c-Myc DNA. Anticancer agent 263 is a structure modulator, showcasing a significant enhancement in protein α-helix formation and the capability to form supramolecular network. Anticancer agent 263 shows no cytotoxicity .
Cat. No.: HY-P10534
CAS No.: 873582-78-6
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ccβ is a 17-residue peptide that folds into a coiled-coil trimer at low temperatures and aggregates to form amyloid fibrils at high temperatures. ccβ serves as a simple model system for investigating α-helix to β-sheet conformational transitions and template-mediated aggregation processes associated with prion and amyloidogenic diseases. ccβ can be used in studies of prion diseases and Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
