Aurein 1.2
Based on 1 Customer Validation
Aurein 1.2 is a C-terminally amidated antimicrobial peptide found in Litoria raniformis. Aurein 1.2 exhibits moderate, broad-spectrum antimicrobial activity against a variety of bacteria, with a MIC of 12-100 μg/mL. Aurein 1.2 forms an amphipathic α-helix with distinct hydrophilic and hydrophobic faces, and may exert antimicrobial and cytotoxic effects on tumor cells by disrupting cell membranes. Aurein 1.2 can be used in studies related to antimicrobial peptides, membrane-active peptides, and tumor cytotoxicity.
For research use only. We do not sell to patients.
- Purity: 99.21%
- CAS No.: 302343-01-7
- Formula: C71H114N16O18
- Molecular Weight:1479.76
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Biological Activity
Aurein 1.2 exhibits moderate and relatively broad-spectrum antimicrobial activity, with an MIC of 12 μg/mL against Leuconostoc lactis, an MIC of 50 μg/mL against Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus uberis, an MIC of 100 μg/mL against Bacillus cereus, Listeria innocua, Micrococcus luteus and Pasteurella multocida, and an MIC >100 μg/mL against Escherichia coli[1].
Aurein 1.2 exhibits cytotoxicity against 52 out of 54 human tumor cell lines in the NCI Phase II screening, with an LC50 of 10-5 M against cell panels of lung cancer, colon cancer, central nervous system tumors, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer, and an LC50 of 10-4-10-5 M against the leukemia cell panel[1].
Aurein 1.2 causes no significant erythrocyte hemolysis at 100 μg/mL, while the complete hemolysis concentration is 1 mg/mL[1].
Aurein 1.2 (9.7 mM; 70% trifluoroethanol/H2O; pH 2.04; 25°C) forms a regular linear amphipathic α-helix with clearly separated hydrophilic and hydrophobic surfaces in NMR structural analysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 302343-01-7
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Appearance Solid
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Molecular Weight 1479.76
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Formula C71H114N16O18
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Color White to off-white
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Sequence
Gly-Leu-Phe-Asp-Ile-Ile-Lys-Lys-Ile-Ala-Glu-Ser-Phe-NH2
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Sequence Shortening
GLFDIIKKIAESF-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (67.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6758 mL | 3.3789 mL | 6.7579 mL | 16.8946 mL |
| 5 mM | 0.1352 mL | 0.6758 mL | 1.3516 mL | 3.3789 mL | |
| 10 mM | 0.0676 mL | 0.3379 mL | 0.6758 mL | 1.6895 mL | |
| 15 mM | 0.0451 mL | 0.2253 mL | 0.4505 mL | 1.1263 mL | |
| 20 mM | 0.0338 mL | 0.1689 mL | 0.3379 mL | 0.8447 mL | |
| 25 mM | 0.0270 mL | 0.1352 mL | 0.2703 mL | 0.6758 mL | |
| 30 mM | 0.0225 mL | 0.1126 mL | 0.2253 mL | 0.5632 mL | |
| 40 mM | 0.0169 mL | 0.0845 mL | 0.1689 mL | 0.4224 mL | |
| 50 mM | 0.0135 mL | 0.0676 mL | 0.1352 mL | 0.3379 mL | |
| 60 mM | 0.0113 mL | 0.0563 mL | 0.1126 mL | 0.2816 mL |
Aurein 1.2 Related Classifications
HY-P5726 Related Classifications
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