ccβ
ccβ is a 17-residue peptide that folds into a coiled-coil trimer at low temperatures and aggregates to form amyloid fibrils at high temperatures. ccβ serves as a simple model system for investigating α-helix to β-sheet conformational transitions and template-mediated aggregation processes associated with prion and amyloidogenic diseases. ccβ can be used in studies of prion diseases and Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 873582-78-6
- Formula: C88H157N29O27
- Molecular Weight:2053.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
ccβ forms a thermodynamically stable native-like coiled-coil α-helical structure at temperatures below 0.71 ε/KB, and transitions to a β-strand-rich structure at temperatures above 0.71 ε/KB[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 873582-78-6
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Molecular Weight 2053.37
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Formula C88H157N29O27
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Sequence
Ser-Ile-Arg-Glu-Leu-Glu-Ala-Arg-Ile-Arg-Glu-Leu-Glu-Leu-Arg-Ile-Gly
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Sequence Shortening
SIRELEARIRELELRIG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ccβ Related Classifications
HY-P10534 Related Classifications
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