33 Results for "

Leu-Leu

" in MedChemExpress (MCE) Product Catalog:
Products (33)

33 Results for "Leu-Leu" in MCE Product Catalog:

2255
2255 Publications Verification
Cat. No.: HY-13259
CAS No.: 133407-82-6
Purity:  99.90%
Synonyms: Z-Leu-Leu-Leu-al; MG132
Research Areas:  

Cancer

MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .
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22
22 Cited Publications
Cat. No.: HY-129905
CAS No.: 6491-83-4
Purity:  98.92%
Synonyms: LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress .
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22
22 Cited Publications
Cat. No.: HY-129905A
CAS No.: 16689-14-8
Purity:  99.69%
Synonyms: LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress .
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18
18 Cited Publications
Cat. No.: HY-13259C
CAS No.: 1211877-36-9
Purity:  99.97%
Synonyms: (S,R,S)-(-)-MG-132; Z-Leu-D-Leu-Leu-al
Target:  

Proteasome

Research Areas:  

Cancer

(R)-MG-132 ((S,R,S)-(-)-MG-132) is the enantiomer of MG-132. (R)-MG-132 is a proteasome inhibitor with weaker cell cytotoxicity than MG-132 .
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16
16 Cited Publications
Cat. No.: HY-P1002
CAS No.: 94367-21-2
Synonyms: Suc-LLVY-AMC
Research Areas:  

Others

Suc-Leu-Leu-Val-Tyr-AMC is a membrane-permeable calpain-specific fluorogenic substrate (Ex/Em = 390/480 nm) .
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3
3 Cited Publications
Cat. No.: HY-123053
CAS No.: 348086-66-8
Purity:  99.91%
Synonyms: Z-LLE-AMC
Target:  

Proteasome

Research Areas:  

Neurological Disease

Z-Leu-Leu-Glu-AMC (Z-LLE-AMC) is a peptide-AMC linked substrate used to measure the postacidic-like hydrolysing activity of proteasome. Z-Leu-Leu-Glu-AMC can be used for the research of parkinson's disease .
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1
1 Cited Publications
Cat. No.: HY-128577
CAS No.: 494830-67-0
Purity:  99.80%
Target:  

BTB/POZ Family

Research Areas:  

Cancer

NIC3 is a selective nucleus accumbens-associated protein-1 (NAC1) inhibitor, binds to the conserved Leu-90 of NAC1, prevents its homodimerization, and leads to proteasomal NAC1 degradation. Anti-cancer activity .
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1
1 Cited Publications
Cat. No.: HY-108551
CAS No.: 179324-22-2
Purity:  ≥95.0%
Synonyms: Z-Leu-Leu-LeuB(OH)2; ZL3B
MG-262 (Z-Leu-Leu-LeuB(OH)2; ZL3B) is a reversible proteasome inhibitor. MG-262 down-regulates VEGF receptor Flt-1. MG-262 inhibits cell growth and induces apoptosis in malignant cells. MG-262 induces reactive oxygen species (ROS). MG-262 can be used for anti-cancer study .
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Cat. No.: HY-W008642
CAS No.: 3303-31-9
Synonyms: L-Leucyl-L-Leucine; Leu-Leu; H-Leu-Leu-OH
Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .
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Cat. No.: HY-129867
CAS No.: 152015-61-7
Synonyms: Z-LLL-AMC
Target:  

Proteasome

Research Areas:  

Others

Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .
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Cat. No.: HY-120234
CAS No.: 133407-83-7
Purity:  97.61%
Synonyms: Z-Leu-Leu-Nle-CHO; GSII
Research Areas:  

Cancer

Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia .
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Cat. No.: HY-W011116
CAS No.: 10329-75-6
Synonyms: H-Leu-Leu-Leu-OH; TriLeucine
Research Areas:  

Others

(S)-2-((S)-2-((S)-2-Amino-4-methylpentanamido)-4-methylpentanamido)-4-methylpentanoic acid is a leucine derivative .
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Cat. No.: HY-P5975
CAS No.: 371167-61-2
Synonyms: Z-LLL-FMK
Target:  

Cathepsin SARS-CoV

Research Areas:  

Infection

Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge .
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Cat. No.: HY-P4383
CAS No.: 20274-80-0
Target:  

Inhibitory Antibodies

Research Areas:  

Others

H-Leu-Leu-Ala-OH is a tripeptide composed of two L-leucine units joined to L-alanine by a peptide linkage. H-Leu-Leu-Ala-OH shows antioxidant activities .
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Cat. No.: HY-137286
CAS No.: 75873-85-7
Synonyms: Z-Leu-Leu-Glu-β-naphthylamide
Target:  

Proteasome

Research Areas:  

Others

Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for determination of the glutamylpeptidyl-peptide hydrolase activity of the 20S proteasome .
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Cat. No.: HY-13259G
CAS No.: 133407-82-6
Synonyms: Z-Leu-Leu-Leu-al (GMP)
MG-132 (GMP) (Z-Leu-Leu-Leu-al (GMP)) is MG-132 (HY-13259) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .
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Cat. No.: HY-P4390
CAS No.: 90468-17-0
Target:  

Cathepsin

Research Areas:  

Others

Z-Leu-Leu-Arg-AMC is a peptide substrate of cathepsin S .
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Cat. No.: HY-DY1060
CAS No.: 94367-21-2
Suc-Leu-Leu-Val-Tyr-AMC (solution) is a membrane-permeable calpain-specific fluorogenic substrate (Ex/Em = 390/480 nm) .
Solvent and concentration: DMSO: 20 mM
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Cat. No.: HY-P4813
CAS No.: 315197-73-0
Target:  

DNA/RNA Synthesis

Research Areas:  

Metabolic Disease

Preptin, an osteogenic peptide product of the pancreatic beta-cell, corresponds to Asp 69-Leu 102 of pro-IGF-II .
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Cat. No.: HY-W008642R
CAS No.: 3303-31-9
Synonyms: L-Leucyl-L-Leucine (Standard); Leu-Leu (Standard); H-Leu-Leu-OH (Standard)
Leu-Leu-OH (Standard) is the analytical standard of Leu-Leu-OH (HY-W008642). This product is intended for research and analytical applications. Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .
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