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Leu-Leu

" in MedChemExpress (MCE) Product Catalog:

標的別:	Amino Acid Derivatives (3) Apoptosis (4) Autophagy (2) Bacterial (2) Biochemical Assay Reagents (1) BTB/POZ Family (1) Cathepsin (2) ClpP (1) DNA/RNA Synthesis (1) Endogenous Metabolite (2) Fluorescent Dye (2) Isotope-Labeled Compounds (1) Proteasome (13) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Renin (1) SARS-CoV (1) VEGFR (1) γ-secretase (1)
研究分野別:	Cancer (9) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (1)

阻害剤およびアゴニスト

蛍光色素

生化学アッセイ試薬

ペプチド

天然物

同位体標識化合物

製品番号	製品名	Target	研究分野	構造式

HY-13259

MG-132 Maximum Cited Publications 1998 Publications Verification Z-Leu-Leu-Leu-al; MG132	Proteasome Autophagy Apoptosis	Cancer
MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .

HY-129905

L-Leucyl-L-Leucine methyl ester hydrochloride 15+ Cited Publications LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride	Endogenous Metabolite	Inflammation/Immunology
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress .

HY-129905A

L-Leucyl-L-Leucine methyl ester hydrobromide 15+ Cited Publications LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide	Endogenous Metabolite	Inflammation/Immunology
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress .

HY-P1002

*Suc-Leu-Leu-Val-Tyr-AMC* 15+ Cited Publications Suc-LLVY-AMC	Fluorescent Dye Proteasome	Others
Suc-Leu-Leu-Val-Tyr-AMC is a membrane-permeable calpain-specific fluorogenic substrate (Ex/Em = 390/480 nm) .

HY-13259C

(R)-MG-132 15+ Cited Publications (S,R,S)-(-)-MG-132; Z-Leu-D-Leu-Leu-al	Proteasome	Cancer
(R)-MG-132 ((S,R,S)-(-)-MG-132) is the enantiomer of MG-132. (R)-MG-132 is a proteasome inhibitor with weaker cell cytotoxicity than MG-132 .

HY-123053

*Z-Leu-Leu-Glu-AMC* 3 Publications Verification Z-LLE-AMC	Proteasome	Neurological Disease
Z-Leu-Leu-Glu-AMC (Z-LLE-AMC) is a peptide-AMC linked substrate used to measure the postacidic-like hydrolysing activity of proteasome. Z-Leu-Leu-Glu-AMC can be used for the research of parkinson's disease .

HY-W008642

Leu-Leu-OH L-Leucyl-L-Leucine; Leu-Leu; H-Leu-Leu-OH	Amino Acid Derivatives	Metabolic Disease
Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

HY-128577

NIC3 1 Publications Verification	BTB/POZ Family	Cancer
NIC3 is a selective nucleus accumbens-associated protein-1 (NAC1) inhibitor, binds to the conserved Leu-90 of NAC1, prevents its homodimerization, and leads to proteasomal NAC1 degradation. Anti-cancer activity .

HY-108551

MG-262 1 Publications Verification Z-Leu-Leu-LeuB(OH)2; ZL3B	Proteasome VEGFR Apoptosis Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology Cancer
MG-262 (Z-Leu-Leu-LeuB(OH)2; ZL3B) is a reversible proteasome inhibitor. MG-262 down-regulates VEGF receptor Flt-1. MG-262 inhibits cell growth and induces apoptosis in malignant cells. MG-262 induces reactive oxygen species (ROS). MG-262 can be used for anti-cancer study .

HY-129867

*Z-Leu-Leu-Leu-AMC* Z-LLL-AMC	Proteasome	Others
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .

HY-120234

Z-LLNle-CHO Z-Leu-Leu-Nle-CHO; GSII	γ-secretase Proteasome Apoptosis	Cancer
Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia .

HY-W011116

*Leu-Leu-Leu* H-Leu-Leu-Leu-OH; TriLeucine	Amino Acid Derivatives	Others
(S)-2-((S)-2-((S)-2-Amino-4-methylpentanamido)-4-methylpentanamido)-4-methylpentanoic acid is a leucine derivative .

HY-P5975

*Z-Leu-Leu-Leu-fluoromethyl ketone* Z-LLL-FMK	Cathepsin SARS-CoV	Infection
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge .

HY-137286

*Z-Leu-Leu-Glu-βNA* Z-Leu-Leu-Glu-β-naphthylamide	Proteasome	Others
Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for determination of the glutamylpeptidyl-peptide hydrolase activity of the 20S proteasome .

HY-13259G

MG-132 Z-Leu-Leu-Leu-al	Proteasome Autophagy Apoptosis	Cancer
MG-132 (GMP) (Z-Leu-Leu-Leu-al (GMP)) is MG-132 (HY-13259) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .

HY-P4390

*Z-Leu-Leu-Arg-AMC*	Cathepsin	Others
Z-Leu-Leu-Arg-AMC is a peptide substrate of cathepsin S .

HY-DY1060

*Suc-Leu-Leu-Val-Tyr-AMC (solution)*	Proteasome Fluorescent Dye	Others
Suc-Leu-Leu-Val-Tyr-AMC (solution) is a membrane-permeable calpain-specific fluorogenic substrate (Ex/Em = 390/480 nm) . Solvent and concentration: DMSO: 20 mM

HY-P4813

Preptin (rat)	DNA/RNA Synthesis	Metabolic Disease
Preptin, an osteogenic peptide product of the pancreatic beta-cell, corresponds to Asp ⁶⁹-Leu ¹⁰² of pro-IGF-II .

HY-W008642R

Leu-Leu-OH (Standard) L-Leucyl-L-Leucine (Standard); Leu-Leu (Standard); H-Leu-Leu-OH (Standard)	Amino Acid Derivatives Reference Standards	Metabolic Disease
Leu-Leu-OH (Standard) is the analytical standard of Leu-Leu-OH (HY-W008642). This product is intended for research and analytical applications. Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

HY-P4399

Z-Gly-Gly-Leu-AMC	Bacterial ClpP	Others
Z-Gly-Gly-Leu-AMC is the substrate of ClpP1 and ClpP2, to detect the enzymatic activity in the presence of the activating peptide Z-Leu-Leu .

HY-N13698

*Cyclo(Leu-Leu)*	Others	Others
Cyclo(Leu-Leu) is a natural product .

HY-P4291

*Z-Leu-Leu-Tyr-COCHO*	Proteasome	Others
Z-Leu-Leu-Tyr-COCHO is a potent chymotrypsin-like activity inhibitor with a K_i value of 3.0 nM .

HY-P3690

*Ac-Leu-Leu-Norleucinol*	Proteasome	Others
Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST) .

HY-P5976

*Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC* Renin Substrate I	Renin	Others
Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC (Renin Substrate I) is a renin substrate

HY-138096

Z-LLF-CHO Z-Leu-Leu-Phe-CHO	Proteasome	Cancer
Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (K_i = 460 nM). Z-LLF-CHO is also a NF-κB nuclear translocation inhibitor .

HY-W008642S

(Leu-13C6,15N)-Leu-OH TFA L-Leucyl-13C6,15N-L-Leucine TFA	Isotope-Labeled Compounds	Others
(Leu-13C6,15N)-Leu-OH TFA is a C13 and N15 labeled Leu-Leu-OH TFA. Leu-Leu-OH, a Leu derivative, is a dipeptide .

HY-P10058

cpm-1285m	Biochemical Assay Reagents	Cancer
cpm-1285m is a cell-permeable mutated peptide analogue of cpm-1285 (Bcl-2 inhibitory peptide). cpm-1285m contains a single substitution of alanine for Leu-151, and exhibits a decrease in Bcl-2 binding affinity with a reduction in IC₅₀ of ∼15-fold. cpm-1285m can be used as a control of cpm-1285 .

HY-182784

Antibacterial agent 336	Bacterial	Infection
Antibacterial agent 336 is an antibacterical agent with broad-spectrum inhibitory activity against Gram-negative and Gram-positive bacteria. Antibacterial agent 336 binds tightly via its pyridine group to the carboxyl group, Lys-465 residue, and Leu-480 residue of the MsbA protein, interfering with bacterial outer membrane synthesis, and exerts concentration-dependent bactericidal activity against bacterial. Antibacterial agent 336 has low cytotoxicity to normal human liver cells. Antibacterial agent 336 can be used for the research of bacterial infections .

製品番号	製品名	Type

HY-P1002

*Suc-Leu-Leu-Val-Tyr-AMC* 15+ Cited Publications Suc-LLVY-AMC	蛍光色素
Suc-Leu-Leu-Val-Tyr-AMC is a membrane-permeable calpain-specific fluorogenic substrate (Ex/Em = 390/480 nm) .

HY-13259G

MG-132 Z-Leu-Leu-Leu-al	蛍光色素
MG-132 (GMP) (Z-Leu-Leu-Leu-al (GMP)) is MG-132 (HY-13259) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .

MG-132

Z-Leu-Leu-Leu-al

蛍光色素

MG-132 (GMP) (Z-Leu-Leu-Leu-al (GMP)) is MG-132 (HY-13259) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .

HY-DY1060

*Suc-Leu-Leu-Val-Tyr-AMC (solution)*	蛍光色素
Suc-Leu-Leu-Val-Tyr-AMC (solution) is a membrane-permeable calpain-specific fluorogenic substrate (Ex/Em = 390/480 nm) . Solvent and concentration: DMSO: 20 mM

製品番号	製品名	Type

HY-13259G

MG-132 Z-Leu-Leu-Leu-al	生化学アッセイ試薬
MG-132 (GMP) (Z-Leu-Leu-Leu-al (GMP)) is MG-132 (HY-13259) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .

MG-132

Z-Leu-Leu-Leu-al

生化学アッセイ試薬

製品番号	製品名	Target	研究分野

HY-P1002

*Suc-Leu-Leu-Val-Tyr-AMC* 15+ Cited Publications Suc-LLVY-AMC	Fluorescent Dye Proteasome	Others
Suc-Leu-Leu-Val-Tyr-AMC is a membrane-permeable calpain-specific fluorogenic substrate (Ex/Em = 390/480 nm) .

HY-123053

*Z-Leu-Leu-Glu-AMC* 3 Publications Verification Z-LLE-AMC	Proteasome	Neurological Disease
Z-Leu-Leu-Glu-AMC (Z-LLE-AMC) is a peptide-AMC linked substrate used to measure the postacidic-like hydrolysing activity of proteasome. Z-Leu-Leu-Glu-AMC can be used for the research of parkinson's disease .

HY-W008642

Leu-Leu-OH L-Leucyl-L-Leucine; Leu-Leu; H-Leu-Leu-OH	Amino Acid Derivatives	Metabolic Disease
Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

HY-129867

*Z-Leu-Leu-Leu-AMC* Z-LLL-AMC	Proteasome	Others
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .

HY-120234

Z-LLNle-CHO Z-Leu-Leu-Nle-CHO; GSII	γ-secretase Proteasome Apoptosis	Cancer
Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia .

HY-W011116

*Leu-Leu-Leu* H-Leu-Leu-Leu-OH; TriLeucine	Amino Acid Derivatives	Others
(S)-2-((S)-2-((S)-2-Amino-4-methylpentanamido)-4-methylpentanamido)-4-methylpentanoic acid is a leucine derivative .

HY-P5975

*Z-Leu-Leu-Leu-fluoromethyl ketone* Z-LLL-FMK	Cathepsin SARS-CoV	Infection
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge .

HY-P4383

*H-Leu-Leu-Ala-OH*	ペプチド	Others
H-Leu-Leu-Ala-OH is a tripeptide composed of two L-leucine units joined to L-alanine by a peptide linkage. H-Leu-Leu-Ala-OH shows antioxidant activities .

HY-137286

*Z-Leu-Leu-Glu-βNA* Z-Leu-Leu-Glu-β-naphthylamide	Proteasome	Others
Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for determination of the glutamylpeptidyl-peptide hydrolase activity of the 20S proteasome .

HY-P4390

*Z-Leu-Leu-Arg-AMC*	Cathepsin	Others
Z-Leu-Leu-Arg-AMC is a peptide substrate of cathepsin S .

HY-P4813

Preptin (rat)	DNA/RNA Synthesis	Metabolic Disease
Preptin, an osteogenic peptide product of the pancreatic beta-cell, corresponds to Asp ⁶⁹-Leu ¹⁰² of pro-IGF-II .

HY-W008642R

Leu-Leu-OH (Standard) L-Leucyl-L-Leucine (Standard); Leu-Leu (Standard); H-Leu-Leu-OH (Standard)	Amino Acid Derivatives Reference Standards	Metabolic Disease
Leu-Leu-OH (Standard) is the analytical standard of Leu-Leu-OH (HY-W008642). This product is intended for research and analytical applications. Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

HY-P4399

Z-Gly-Gly-Leu-AMC	Bacterial ClpP	Others
Z-Gly-Gly-Leu-AMC is the substrate of ClpP1 and ClpP2, to detect the enzymatic activity in the presence of the activating peptide Z-Leu-Leu .

HY-P4291

*Z-Leu-Leu-Tyr-COCHO*	Proteasome	Others
Z-Leu-Leu-Tyr-COCHO is a potent chymotrypsin-like activity inhibitor with a K_i value of 3.0 nM .

HY-P4491

*Suc-Leu-Leu-Val-Tyr-pNA*	ペプチド	Others
Suc-Leu-Leu-Val-Tyr-pNA is a chymotrypsin-like chromogenic substrate that can be used to detect chymotrypsin enzymatic activity .

HY-P3690

*Ac-Leu-Leu-Norleucinol*	Proteasome	Others
Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST) .

HY-P5976

*Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC* Renin Substrate I	Renin	Others
Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC (Renin Substrate I) is a renin substrate

HY-138096

Z-LLF-CHO Z-Leu-Leu-Phe-CHO	Proteasome	Cancer
Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (K_i = 460 nM). Z-LLF-CHO is also a NF-κB nuclear translocation inhibitor .

HY-115379

Latromotide	ペプチド	Cancer
Latromotide is a synthetic peptide with antineoplastic activity. It consists of 10 amino acids corresponding to amino acid residues 66-75 of the human kinesin-like protein KIF20A. Latromotide has a sequence of H-Lys-Val-Tyr-Leu-Arg-Val-Arg-Pro Leu-Leu-OH .

HY-P10058

cpm-1285m	Biochemical Assay Reagents	Cancer
cpm-1285m is a cell-permeable mutated peptide analogue of cpm-1285 (Bcl-2 inhibitory peptide). cpm-1285m contains a single substitution of alanine for Leu-151, and exhibits a decrease in Bcl-2 binding affinity with a reduction in IC₅₀ of ∼15-fold. cpm-1285m can be used as a control of cpm-1285 .

製品番号	製品名	Category	Target	構造式

HY-129905

L-Leucyl-L-Leucine methyl ester hydrochloride 15+ Cited Publications LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride	天然物 Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress .

HY-129905A

L-Leucyl-L-Leucine methyl ester hydrobromide 15+ Cited Publications LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide	天然物 Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress .

HY-W008642

Leu-Leu-OH L-Leucyl-L-Leucine; Leu-Leu; H-Leu-Leu-OH	天然物 Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Amino Acid Derivatives
Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

HY-W008642R

Leu-Leu-OH (Standard) L-Leucyl-L-Leucine (Standard); Leu-Leu (Standard); H-Leu-Leu-OH (Standard)	天然物 Endogenous metabolite Source Classification	Amino Acid Derivatives Reference Standards
Leu-Leu-OH (Standard) is the analytical standard of Leu-Leu-OH (HY-W008642). This product is intended for research and analytical applications. Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

HY-N13698

*Cyclo(Leu-Leu)*	Alkaloids Microorganisms Other Alkaloids Source Classification	Others
Cyclo(Leu-Leu) is a natural product .

製品番号	製品名	構造式

HY-W008642S

(Leu-13C6,15N)-Leu-OH TFA
(Leu-13C6,15N)-Leu-OH TFA is a C13 and N15 labeled Leu-Leu-OH TFA. Leu-Leu-OH, a Leu derivative, is a dipeptide .

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