371167-61-2
371167-61-2
Chemical Structure
Z-Leu-Leu-Leu-fluoromethyl ketone
Synonym(s): Z-LLL-FMK
- CAS No.: 371167-61-2
- Formula:C27H42FN3O5
- Molecular Weight:507.64
InChIKey: HLXJVMRDGBCZCM-VABKMULXSA-N
SMILES: O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(CF)=O)=O)=O
Biological Activity: Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge[1][2].
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Z-Leu-Leu-Leu-fluoromethyl ketone | Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge. | |||||||||||||||||||||
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References
- [1]. Simmons G, et al. Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11876-81. [Content Brief]
- [2]. Baig S, et al. Cysteine proteinase inhibitors in murine cysticercosis. Antimicrob Agents Chemother. 2006 Aug;50(8):2886-8. [Content Brief]
Keywords
