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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
44 Results for "
5-HTIA
" in MedChemExpress (MCE) Product Catalog:
Products (44)
44 Results for "5-HTIA" in MCE Product Catalog:
1
1 Cited Publications
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5-HT2A receptor agonist-1 (Compound 3) is a selective 5-HT2A receptor agonist with the EC50 of 5.54 nM. 5-HT2A receptor agonist-1 can be used for the research of mood disorders .
Cat. No.: HY-161247
CAS No.: 2641482-08-6
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5HT2A antagonist 2 is an orally active, selective antagonist for 5HT2A with IC50 of 14 nM. 5-HT2A antagonist 2 exhibits good chemical, hepatocyte, and plasma stability, without significant cytotoxicity in cell lines VERO, HFL-1, L929, NIH3T3, CHO-K1 .
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5-HT2A receptor agonist-3 ((S,S)-9b) is a 5-HT2A receptor agonist with a Ki of 2.5 nM for human 5-HT2A receptor. 5-HT2A receptor agonist-3 shows 124-fold selectivity for 5-HT2A over the structurally similar 5-HT2C receptor .
Cat. No.: HY-19950
CAS No.: 1028307-48-3
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5-HT2A receptor agonist-6 (compound 47) is a selective 5-HT2A receptor agonist (pEC50=6.58) .
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5-HT1A modulator 2 hydrochloride, a derivative of 8-OH-DPAT (HY-112061), is a modulator of 5-HT1A with a Ki of 53 nM for 5-HT1A binding .
Cat. No.: HY-175511
CAS No.: 2864368-10-3
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5-HT2A agonist 7 (Compound 45) is an orally active and highly selective serotonin receptor 2A (5-HT2A) agonist (EC50=12 nM). 5-HT2A agonist 7 is promising for research of psychiatric disorders such as depression .
Cat. No.: HY-145841
CAS No.: 528525-37-3
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5-HT2A receptor agonist-2 is a highly potent serotonin 5-HT2 receptor agonists. 5-HT2A receptor agonist-2 inspires 5-HT2A, 5-HT2B, and 5-HT2C with EC50 values of 1.7, 0.58, and 0.50 nM, respectively .
Cat. No.: HY-175822
CAS No.: 3028943-38-3
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5-HT2A inverse agonist-1 is a 5-HT2A receptor inverse agonist with a IC50 of 5.5 nM. 5-HT2A inverse agonist-1 shows minimal hERG inhibition. 5-HT2A inverse agonist-1 can be used for the research of neurological disease, such as Parkinson’s disease .
Cat. No.: HY-179291
CAS No.: 3006788-03-7
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5-HT2A agonist 8 (Compound 67) is a 5-HT2A agonist, with an EC50 of 4 nM. 5-HT2A agonist 8 can be used in the research of neuropsychiatric and neurodegenerative diseases .
Cat. No.: HY-175657
CAS No.: 2956765-08-3
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5-HT2A receptor agonist-12 (compound 161-2) is a potent 5-HT2A agonist with an EC50 value of <100 nM for h5-HT2A .
Cat. No.: HY-179063
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5-HT2A receptor agonist-13 (Compound 28c) is a partial agonist of the 5-HT2A receptor, with an EC50 value of 416.9 nM and a Ki value of 113.9 nM. 5-HT2A receptor agonist-13 exhibits very weak agonistic activity towards the 5-HT2B receptor (EC50 = 120.2 nM), D2 receptor (Ki = 1298 nM), and has no activity towards the 5-HT2C receptor. 5-HT2A receptor agonist-13 exhibits weak inhibitory activity on the serotonin transporter (SERT) (EC50 = 977.2 nM). 5-HT2A receptor agonist-13 has antidepressant activity in mouse models and does not induce hallucinogenic behavior. 5-HT2A receptor agonist-13 can be used for the study of major depressive disorder (MDD) and treatment-resistant depression (TRD) .
Cat. No.: HY-144764
CAS No.: 3037516-52-9
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5-HT1A antagonist 1 (compound 6f) is a potent and selective antagonist of 5-HT1A receptor, with a Ki of 35 nM. 5-HT1A antagonist 1 can be used for the research of CNS diseases .
Cat. No.: HY-175509
CAS No.: 3044091-48-4
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5-HT2A agonist 6 (compound 2-6) is a 5-HT2A agonist with an EC50 of 1.7 nM. 5-HT2A agonist 6 is used in the study of stress-related disorders, namely depression, anxiety, and post-traumatic stress disorder .
Cat. No.: HY-U00286
CAS No.: 204643-75-4
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5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. 5-HT2A antagonist 1 may be useful in treatment of gastrointestinal disorders circulatory disorders.
Cat. No.: HY-W1123900
CAS No.: 2945111-66-8
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5-HT2A agonist 3 (Compound P-141) is a selective 5-hydroxytryptamine 2A receptor (5-HT2A) agonist with an EC50 value of 13.80 nM. 5-HT2A agonist 3 is promising for research of mental illnesses such as depression, post-traumatic stress disorder, obsessive-compulsive disorder, and central nervous system disorders .
Cat. No.: HY-169786
CAS No.: 2957888-63-8
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5-HT2A receptor agonist-5 (compound I-3) is a potent 5-HT2A receptor agonist with a Ki value of 0.017 µM. 5-HT2A receptor agonist-5 shows antidepressant activity .
Cat. No.: HY-172978
CAS No.: 2855122-44-8
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5-HT2A receptor agonist-8 (compound 8) is a potent 5-HT2A receptor agonist with an EC50 of 0.6784 nM. 5-HT2A receptor agonist-8 can be used in the study of depressive disorders and bipolar disorders .
Cat. No.: HY-172980
CAS No.: 3035280-33-9
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5-HT2A receptor agonist-9 (Compound 9) is a β-arrestin-biased 5-HT2A receptor agonist. 5-HT2A receptor agonist-9 can be used in the research of neurological diseases such as antidepressant and psychedelic .
Cat. No.: HY-173269
CAS No.: 3066340-41-5
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5-HT2A receptor agonist-7 (517) is a 5-HT2A modulator, with an EC50 of <100 nM .
Cat. No.: HY-174909
CAS No.: 3088416-38-7
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5-HT2A receptor agonist-11 (Compound I-69) is a 5-HT2A receptor agonist with an EC50 of 22 nM. 5-HT2A receptor agonist-11 can be used in the research of mental illness or central nervous system disorders .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
