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6PPD-Q

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By Targets:	Biochemical Assay Reagents (1) Drug Derivative (2) Drug Metabolite (1) Environmental Pollutants (1) Isotope-Labeled Compounds (1) α-synuclein (1)

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Natural
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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153169

*6PPD-Q* 5+ Cited Publications 6PPD-Quinone	α-synuclein Environmental Pollutants	Others
6PPD-Q (6PPD-Quinone) is an environmental pollutant that can be detected in human urine and is widely present in the environment. 6PPD-Q targets and binds to CNR2, CNR1, AA2AR, LCAT, and TRPA1, with CNR2 exhibiting the highest binding affinity, potentially acting as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q induces intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolysis metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. 6PPD-Q is applicable in research on environmental toxicology, neurodegenerative diseases, and inflammation-related disorders .

HY-152039S1

6PPD-Q-13C6 6PPD-Quinone-¹³C₆	Isotope-Labeled Compounds	Others
6PPD-quinone- ¹³C₆ is the ¹³C labeled 6PPD-quinone .

HY-175134

6PPD-Q-1-OH TP-OH1	Drug Derivative	Others
6PPD-Q-1-OH is an oxidized derivative of the oxidized p-phenylenediamine 6-PPD-Q .

HY-175114

p-Hydroxy 6-PPD-Q	Drug Derivative	Others
P-hydroxy 6-PPD-Q is a derivative of 6PPD-Q (HY-153169) .

HY-176151

HPPD-Q HPPD-quinone	Biochemical Assay Reagents	Others
HPPD-Q (HPPD-quinone) is a substituted p-phenylenediamine quinone and derivative of 6-PPD-Q.

HY-175400

6-PPD-Q-4-OH 6-PPD-quinone-4-OH	Drug Metabolite	Others
6-PPD-Q-4-OH (6-PPD-quinone-4-OH) is a metabolite of 6PPD-Q (HY-153169). 6-PPD-Q-4-OH is applicable to exposure studies of 6PPD-Q, an environmental pollutant .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-153169

*6PPD-Q* 5+ Cited Publications 6PPD-Quinone	Quinones Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Other Diseases Benzene Quinones Endogenous metabolite Disease Research Fields Source Classification	α-synuclein Environmental Pollutants
6PPD-Q (6PPD-Quinone) is an environmental pollutant that can be detected in human urine and is widely present in the environment. 6PPD-Q targets and binds to CNR2, CNR1, AA2AR, LCAT, and TRPA1, with CNR2 exhibiting the highest binding affinity, potentially acting as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q induces intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolysis metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. 6PPD-Q is applicable in research on environmental toxicology, neurodegenerative diseases, and inflammation-related disorders .

Cat. No.	Product Name	Chemical Structure

HY-152039S1

6PPD-Q-13C6
6PPD-quinone- ¹³C₆ is the ¹³C labeled 6PPD-quinone .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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6PPD-Q

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products