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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
ABCB11/BSEP
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "ABCB11/BSEP" in MCE Product Catalog:
Cat. No.: HY-189393
CAS No.: 3089177-97-6
Target:
Research Areas:
RTY-406 is an orally active ABCB4/MDR3 and ABCB11/BSEP positive modulator. RTY-406 increases ABCB4/MDR3 and ABCB11/BSEP protein levels and functional output, elevates biliary phospholipid levels, enhances bile acid efflux, increases bile flow and micelle formation, reduces hepatic bile acids, and promotes cholesterol-to-bile-acid conversion. RTY-406 does not induce hepatocellular injury, maintains normal serum alanine transaminase and aspartate aminotransferase levels, and shows a favorable safety profile in cynomolgus monkeys. RTY-406 can be used for the research of primary sclerosing cholangitis and cholestasis .
Cat. No.: HY-P703251
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ABCB11; SPGP; Prev. BSEP; Progressive Familial Intrahepatic Cholestasis 2; Prev. PFIC2; ATP-Binding Cassette Sub-Family B Member 11; Bile Salt Export Pump; ABC Member 16, MDR/TAP Subfamily; PFIC-2; Uncharacterized Protein ABCB11; ABC16; Sister P-Glycoprot
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
