1 Result for "

AFD21

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "AFD21" in MCE Product Catalog:

Cat. No.: HY-136995
CAS No.: 99465-44-8
Target:  

Sodium Channel

Research Areas:  

Cardiovascular Disease

AFD-21 maleate is a drug with antiarrhythmic activity. AFD-21 maleate inhibits sodium channels by binding to sodium channels in an inactive state, with both use-dependent and voltage-dependent effects. The unbinding rate of AFD-21 maleate is similar to that of Class I antiarrhythmic drugs with moderate kinetics. AFD-21 maleate can cause a slight prolongation of the action potential duration and significantly reduce the maximum rise rate of the action potential at certain concentrations. AFD-21 maleate also showed use-dependent blocking effects as stimulation frequency increased .
loading...
    loading...