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ALK4290

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136788
    ALK4290

    AKST4290; BI144807

    		 CCR Neurological Disease Inflammation/Immunology Cancer
    ALK4290 (AKST4290) is a potent, orally active and selective CCR3 inhibitor with a Ki of 3.2 nM. ALK4290 blocks CCR3-mediated signaling, abrogates macrophage supernatant-driven mesothelial-to-mesenchymal transition, and decreases p38 phosphorylation. ALK4290 inhibits CCL26-CCR3 axis-driven GPX2-mediated B-cell activation, and targets B cells to inhibit activation by GPX2-overexpressing tumor cells. ALK4290 can be used for the research of hepatocellular carcinome and Parkinson’s disease .
    ALK4290
  • HY-136788A
    ALK4290 dihydrochloride

    AKST4290 dihydrochloride; BI144807 dihydrochloride

    		 CCR Inflammation/Immunology
    ALK4290 dihydrochloride (AKST4290 dihydrochlorid) is a potent and orally active CCR3 inhibitor extracted from patent US20130261153A1, compound Example 2, with a Ki of 3.2 nM for hCCR3 . ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism .
    ALK4290 dihydrochloride

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