6 Results for "

AMPK-ACC

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "AMPK-ACC" in MCE Product Catalog:

5
Alisol A
Alisol A
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5 Cited Publications
Cat. No.: HY-N0853
CAS No.: 19885-10-0
Category:  

Triterpenes Alisma plantago-aquatica Linn. Terpenoids Other Diseases Plants Disease Research Fields Alismataceae Extract

Target:  

AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related

Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .
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4
Isomangiferin
Isomangiferin
0 Images
4 Cited Publications
Cat. No.: HY-N0772
CAS No.: 24699-16-9
Category:  

Infection Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Liliaceae Extract Disease Research Fields

Target:  

VEGFR NOD-like Receptor (NLR) NF-κB Bacterial AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative

Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing .
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CAD031
CAD031
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Cat. No.: HY-124609
CAS No.: 2071209-49-7
Purity:  99.39%
Target:  

AMPK Acetyl-CoA Carboxylase

Research Areas:  

Neurological Disease

CAD031 is an orally active AMPK/ACC1 signaling pathway activator and a derivative of the Alzheimer's disease (AD) targeted agent J147 (HY-13779) (more active than J147 in human neural stem cell assays). CAD031 can cross the blood-brain barrier, activate AMPK and inhibit ACC1, thereby increasing ac-CoA levels, improving mitochondrial function and reducing free fatty acid synthesis. CAD031 has neuroprotective, neurogenesis-promoting and memory-improving activities and can be used in the study of Alzheimer's disease and aging-related neurodegenerative diseases. CAD031 effectively enhances the memory of mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain of elderly mice .
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Isomangiferin (Standard)
Isomangiferin (Standard)
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Cat. No.: HY-N0772R
CAS No.: 24699-16-9
Category:  

Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Liliaceae Extract

Target:  

Reference Standards VEGFR NF-κB NOD-like Receptor (NLR) AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative

Isomangiferin (Standard) is the analytical standard of Isomangiferin (HY-N0772). This product is intended for research and analytical applications. Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing.
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Alisol A (Standard)
Alisol A (Standard)
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Cat. No.: HY-N0853R
CAS No.: 19885-10-0
Category:  

Triterpenes Alisma plantago-aquatica Linn. Terpenoids Plants Alismataceae Extract

Target:  

Reference Standards AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related

Alisol A (Standard) is the analytical standard of Alisol A (HY-N0853). This product is intended for research and analytical applications. Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .
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THR-β agonist 12
THR-β agonist 12
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Cat. No.: HY-184939
CAS No.: 3063509-17-8
Target:  

Thyroid Hormone Receptor AMPK Fatty Acid Synthase (FASN)

Research Areas:  

Inflammation/Immunology

THR-β agonist 12 is an orally active, potent, and highly selective thyroid hormone receptor β (THR-β) agonist (EC50 = 36 nM). THR-β agonist 12 shows no significant activity against THRα and exhibits no cardiotoxicity in vivo. THR-β agonist 12 inhibits lipid synthesis by activating the AMPK-ACC-SREBP1 signaling axis. THR-β agonist 12 can be used on research into metabolic dysfunction-associated steatohepatitis (MASH) and related metabolic diseases .
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