1 Result for "

AP 18

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "AP 18" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-W014421
CAS No.: 55224-94-7
Target:  

TRP Channel

Research Areas:  

Neurological Disease

AP-18, a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 reverses complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 attenuated 30 μM AITC-induced Yo-Pro uptake in a concentration-dependent manner, with an IC50 of 10.3 μM .
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