2 Results for "

Amivantamab

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Amivantamab" in MCE Product Catalog:

3
3 Cited Publications
Referencia número: HY-P9977
No. CAS: 2171511-58-1
Synonyms: JNJ-61186372

Target:  

EGFR

Áreas de investigación:  

Cancer

Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .
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Referencia número: HY-P9977A

Target:  

EGFR

Áreas de investigación:  

Cancer

Amivantamab (FUT8-KO) is an anti-EGFR-MET monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Amivantamab (FUT8-KO) inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .
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