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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
Amonafide
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "Amonafide" in MCE Product Catalog:
5
Target:
Domaines de recherche:
Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.
Cat. No.: HY-10982A
CAS No.: 150091-68-2
Synonyms: AS1413 dihydrochloride
Target:
Domaines de recherche:
Amonafide dihydrochloride (AS1413 dihydrochloride) is a topoisomerase II (Topo II) inhibitor and DNA intercalator with activity in inducing apoptotic signaling. Amonafide dihydrochloride can inhibit the binding of Topo II to DNA, thereby preventing the synthesis of DNA and RNA. Amonafide dihydrochloride maintains cytotoxic activity in the presence of P-glycoprotein-mediated multidrug resistance (MDR) .
Cat. No.: HY-10982R
CAS No.: 69408-81-7
Synonyms: AS1413 (Standard)
Target:
Domaines de recherche:
Amonafide (Standard) is the analytical standard of Amonafide. This product is intended for research and analytical applications. Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.
Cat. No.: HY-117543
CAS No.: 160554-87-0
Synonyms: AMP-53; 6-Ethoxyazonafide
Target:
Domaines de recherche:
Ethonafide (AMP-53) is an anthracene-containing derivative of Amonafide that belongs to the Azonafide series of anticancer agents. Ethonafide (AMP-53) inhibits topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIα and β .
Cat. No.: HY-159560
Target:
Domaines de recherche:
PBA-AMF can be activated by H2O2 to release Amonafide (AMF) (HY-10982). PBA-AMF selectively inhibited the proliferation of breast cancer cells, while sparing non-cancerous cells. PBA-AMF inhibits tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing apoptosis, and arresting the cell cycle. PBA-AMF can be used for research of tumors and other diseases associated with increased H2O2 levels .
Cat. No.: HY-118823
CAS No.: 618863-54-0
Synonyms: AS-1413 L-malate
Domaines de recherche:
Amonafide L-malate is a topoisomerase II inhibitor and DNA intercalator that induces Apoptotic signaling by blocking the binding of Topo II to DNA .
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Protocols
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