618863-54-0
618863-54-0
Chemical Structure
Amonafide L-malate
Synonym(s): AS-1413 L-malate
- CAS No.: 618863-54-0
- Formula:C20H23N3O7
- Molecular Weight:417.41
IUPAC Name: 5-amino-2-(2-(dimethylamino)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (S)-2-hydroxysuccinate
InChIKey: JNZBHHQBPHSOMU-WNQIDUERSA-N
SMILES: OC(C[C@H](O)C(O)=O)=O.O=C1C2=CC(N)=CC3=C2C(C(N1CCN(C)C)=O)=CC=C3
Biological Activity: Amonafide L-malate is a topoisomerase II inhibitor and DNA intercalator that induces Apoptotic signaling by blocking the binding of Topo II to DNA[1][2][3].
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Amonafide L-malate | Amonafide L-malate is a topoisomerase II inhibitor and DNA intercalator that induces Apoptotic signaling by blocking the binding of Topo II to DNA. | |||||||||||||||||||||
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References
- [1]. Allen SL, et al. Amonafide: a potential role in treating acute myeloid leukemia. Expert Opin Investig Drugs. 2011 Jul;20(7):995-1003. [Content Brief]
- [2]. Andersson BS, et al. In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia. Cancer Res. 1987 Feb 15;47(4):1040-4. [Content Brief]
- [3]. Ajani JA, et al. In vitro activity of amonafide against primary human tumors compared with the activity of standard agents. Invest New Drugs. 1988 Jun;6(2):79-85. [Content Brief]
Keywords
