Search Result

Results for "

Anti-HIV-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (3) Bacterial (6) Bcl-2 Family (1) CCR (4) CXCR (3) Cyclophilin (2) Dihydroorotate Dehydrogenase (1) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (2) Drug Derivative (2) Drug Intermediate (6) Fungal (1) HBV (1) HCV (2) HIV (82) HIV Integrase (1) HIV Protease (14) hnRNP (1) IKK (2) Influenza Virus (2) Isotope-Labeled Compounds (3) Microtubule/Tubulin (1) Parasite (2) PKC (1) PROTACs (2) Pyroptosis (1) Reactive Oxygen Species (ROS) (2) Reference Standards (6) Reverse Transcriptase (13) ULK (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (3) Infection (87) Inflammation/Immunology (9) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-104012

Islatravir 2 Publications Verification MK-8591	HIV Reverse Transcriptase	Infection Inflammation/Immunology
Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC₅₀s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. Islatravir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P0052

Enfuvirtide 4 Publications Verification T20; DP178	HIV	Infection
Enfuvirtide (T20;DP178) is an anti-HIV-1 fusion inhibitor peptide.

HY-105231

Bryostatin 1 2 Publications Verification	PKC HIV Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of *Munc13-1* and the full-length *Munc13-1* protein with K_is of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties ^[1] .

HY-N2010

Methyl gallate 4 Publications Verification Gallincin; NSC 363001	Bacterial HIV Reactive Oxygen Species (ROS)	Infection Cardiovascular Disease Cancer
Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Methyl gallate also has anti-HIV-1 and *HIV-1* enzyme inhibitory activities.

HY-12687

Tizoxanide Maximum Cited Publications 13 Publications Verification TIZ	Bacterial HIV Autophagy Parasite IKK Influenza Virus	Infection Cancer
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide *anti-infective* compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has *anti-HIV-1* activities and potent inhibition of both HBV and HCV replication with values EC₅₀ of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells ^[1] .

HY-78726

Fosamprenavir 4 Publications Verification Amprenavir phosphate; GW 433908	Drug Intermediate HIV HIV Protease	Infection
Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection ^[1] .

HY-173011

RJS308	PROTACs Cyclophilin HIV HCV	Infection
RJS308 is a selective Cyclophilin A (CypA) PROTAC degrader. RJS308 induces ubiquitin-dependent CypA degradation by recruiting the VHL E3 ligase complex, and forms a ternary complex with CypA and VHL/elongin C/elongin B. RJS308 exhibits anti-HIV-1 and anti-HCV activities. RJS308 can be used in studies related to viral infections ^[1].

HY-19851

Rovafovir etalafenamide GS-9131	Reverse Transcriptase HIV	Cancer
Rovafovir etalafenamide (GS-9131), a proagent of the adenosine nucleotide analogue GS-9148, is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Rovafovir etalafenamide is potent and active against a variety of NRTI mutants, and shows potent anti-HIV-1 activity ^[1] .

HY-17431

Fosamprenavir Calcium Salt 4 Publications Verification GW433908G	Drug Intermediate HIV HIV Protease	Infection
Fosamprenavir Calcium Salt (GW433908G) is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir Calcium Salt is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir Calcium Salt can be used for the study of human immunodeficiency virus (HIV-1) infection ^[1] .

HY-P0052A

Enfuvirtide acetate 4 Publications Verification T20 acetate; DP178 acetate	HIV	Infection
Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.

HY-W325699

HIV-1 inhibitor-48	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-48 (compound 13o) is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) and exhibits anti-HIV-1 activity ^[1].

HY-N2996

Ganodermanondiol	HIV Protease	Infection
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum ^[1].Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-115488A

BNM-III-170	HIV	Infection
BNM-III-170, CD4-mimeticcompound, is an anti-HIV-1 agent. BNM-III-170 binds to the Phe43 cavity of HIV 1 gp120. BNM-III-170 can inhibits HIV-1 viral entry into target cells. BNM-III-170 can be used for the research of HIV-1 infection ^[1].

HY-173011A

RJS308 TFA	PROTACs Cyclophilin HIV HCV	Infection
RJS308 TFA is a selective Cyclophilin A (CypA) PROTAC degrader. RJS308 TFA induces ubiquitin-dependent CypA degradation by recruiting the VHL E3 ligase complex, and forms a ternary complex with CypA and VHL/elongin C/elongin B. RJS308 TFA exhibits anti-HIV-1 and anti-HCV activities. RJS308 TFA can be used in studies related to viral infections ^[1].

HY-N0556

Isoescin IA	HIV Protease	Infection
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity ^[1].

HY-N0867

13-Oxyingenol-13-dodecanoate	HIV ULK Bcl-2 Family	Infection Cancer
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM ^[1].13-Oxyingenol-dodecanoate can induce the expression of *ULK1* to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis .

HY-N16050

Ethyl salvianolate A Ethyl salvionolate A	HIV Reverse Transcriptase HIV Integrase HIV Protease	Infection
Ethyl salvianolate A (Ethyl salvionolate A) is an anti-HIV-1 compound that can be extracted from the roots of Salvia yunnanensis. Ethyl salvianolate A inhibits P24 antigen in HIV-1 infected MT-4 cell cultures (EC₅₀: 1.44 μg/mL). Ethyl salvianolate A inhibits HIV-1 replicative enzymes, with IC₅₀s of 56.38 μM (Reverse transcriptase), 12.03 μM (Protease), 14.54 μM (Integrase), respectively ^[1].

HY-103078

I-XW-053	HIV Reverse Transcriptase	Infection
I-XW-053 is a specific anti-HIV-1 capsid inhibitor (IC₅₀=164.2 μM). By binding to the CA NTD-NTD hexamerization interface and the R173 region of CTD (K_d=66.3 μM), I-XW-053 disrupts capsid function and reduces polymerization levels. I-XW-053 effectively blocks *HIV-1* uncoating, inhibits reverse transcription and early replication, and exhibits broad-spectrum activity against primary HIV-1 isolates in peripheral blood mononuclear cells. I-XW-053 can be widely used in studies related to HIV-1 infection ^[1] .

HY-N12046

Schineolignin B	HIV	Infection Inflammation/Immunology Cancer
Schineolignin B is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities ^[1].

HY-P99584

Suvizumab KD-247	HIV	Infection
Suvizumab (KD-247) is an neutralizing antibody anti-HIV-1. Suvizumab effectively neutralizes HIV-1_MN, HIV-1_SF2 and HIV-1_89.6 with IC₅₀ values of 0.1 µg/mL, 1.0 µg/mL and 0.2 µg/mL, respectively. Suvizumab reduces the viral load of HIV. Suvizumab has good tolerance and can be used to prevent HIV infection ^[1] .

HY-N10958

Wikstrol A	Fungal HIV Microtubule/Tubulin	Infection
Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC₅₀ value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC₅₀ value of 67.8 µM ^[1].

HY-113818

Kadsuracoccinic acid A	HIV	Infection
Kadsuracoccinic acid A is a tetracyclic natural compound that can be isolated from the stems of Kadsura coccinea. Kadsuracoccinic acid A has vitro *anti-HIV-1* activitiy with an EC₅₀ value of 68.7 μM ^[1].

HY-152132

CCR5 antagonist 3	CCR HIV	Infection
CCR5 antagonist 3 (Compound 26) is a CCR5 antagonist with an IC₅₀ of 15.90 nM. CCR5 antagonist 3 shows broad-spectrum anti-HIV-1 activities ^[1].

HY-P1586

HIV-1 Rev (34-50) HIV-1 rev Protein (34-50)	HIV	Infection
HIV-1 Rev (34-50) is a 17-aa peptide derived from the Rev-responsive element (RRE)-binding domains of Rev in HIV-1, with anti-HIV-1 activity.

HY-177437

(±)-PM 92131	HIV	Infection
(±)-PM 92131 is a non-nucleoside *HIV-1* inhibitor. (±)-PM 92131 has an anti-HIV-1 activity with IC₅₀s of 45.7 and 53.8 μM for HIV-1 RF strain in XTT cytoprotection and syncytium-forming assay, respectively. (±)-PM 92131 can be used for HIV infections research ^[1].

HY-177437A

(+)-PM 92131	HIV	Infection
(+)-PM 92131 is the active enantiomer of (±)-PM 92131 (HY-177437). (+)-PM 92131 is a non-nucleoside *HIV-1* inhibitor. (+)-PM 92131 has an anti-HIV-1 activity with EC₅₀s of 0.8 and 0.6 μM for HIV-1 RF strain in XTT cytoprotection and syncytium-forming assay, respectively. (+)-PM 92131 can be used for HIV infections research ^[1].

HY-78726S

Fosamprenavir-d4 Amprenavir phosphate-d₄; GW 433908-d₄	Isotope-Labeled Compounds Drug Intermediate HIV HIV Protease	Infection
Fosamprenavir-d₄ is the Deuterium-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection ^[1] .

HY-103078A

I-XW-053 sodium	HIV Reverse Transcriptase	Infection
I-XW-053 sodium is a specific anti-HIV-1 capsid inhibitor (IC₅₀=164.2 μM). By binding to the CA NTD-NTD hexamerization interface and the R173 region of CTD (K_d=66.3 μM), I-XW-053 sodium disrupts capsid function and reduces polymerization levels. I-XW-053 sodium effectively blocks *HIV-1* uncoating, inhibits reverse transcription and early replication, and exhibits broad-spectrum activity against primary HIV-1 isolates in peripheral blood mononuclear cells. I-XW-053 sodium can be widely used in studies related to HIV-1 infection ^[1] .

HY-14230

INCB9471	CCR HIV	Infection
INCB9471 is a potent, selective and orally active CCR5 antagonist. INCB9471 shows anti-HIV-1 activity ^[1] .

HY-175667

NNRT-IN-12	HIV Reverse Transcriptase	Infection
NNRT-IN-12 (compound 19) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor with an IC₅₀ value of 0.107 μM for WT HIV-1 RT. NNRT-IN-12 shows anti-HIV-1 activity with EC₅₀ value of 14.1, 5.03, 7.64, 27.1 nM for L100I, K103N, Y181C, Y188L mutant HIV-1 strains, respectively. NNRT-IN-12 shows cytotoxicity ^[1].

HY-10892

HEPT	HIV	Infection
HEPT is a potent and selective anti-HIV-1 agent ^[1].

HY-144730

gp120-IN-1	HIV	Inflammation/Immunology
gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC₅₀ of 2.2 µM and CC₅₀ of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells ^[1].

HY-15571A

VCH-286	HIV CCR	Infection
VCH-286 is a CCR5 inhibitor that exhibits potent in vitro anti-HIV-1 activity when used alone ^[1].

HY-N3502

20(21)-Dehydrolucidenic acid A	HIV Protease	Infection
20(21)-Dehydrolucidenic acid A is a triterpenoid isolated from the fruiting body of the fungus Ganoderma sinense. 20(21)-Dehydrolucidenic acid A has weak anti-HIV-1 protease activity ^[1].

HY-152131

CCR5 antagonist 2	CCR HIV	Infection
CCR5 antagonist 2 (Compound 25) is a CCR5 antagonist with an IC₅₀ of 8.34 nM. CCR5 antagonist 2 shows broad-spectrum anti-HIV-1 activities ^[1].

HY-12687S

Tizoxanide-d4	Isotope-Labeled Compounds Bacterial HIV Autophagy	Infection
Tizoxanide-d₄ is the deuterium labeled Tizoxanide. Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities ^[1] .

HY-N0556R

Isoescin IA (Standard)	Reference Standards HIV Protease	Infection
Isoescin IA (Standard) is the analytical standard of Isoescin IA. This product is intended for research and analytical applications. Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity ^[1].

HY-18666

D77	HIV	Infection
D77 is anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. D77 inhibits HIV-1(IIIB) replication by EC50 value of 23.8 μg/ml in MT-4 cell (5.03 μg/ml for C8166 cells).

HY-118711

HI-346	HIV Reverse Transcriptase	Infection
HI-346 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for *HIV-1* with an IC₅₀ value against the HIV-1 virus strain (HTLV-IIIB) of 3 nM. HI-346 is a vaginal bactericidal contraceptive agent, with its sperm-killing activity having an EC₅₀ value of 42 μM. HI-346 shows no cytotoxicity to normal cells at effective concentrations. HI-346 can be used in anti-HIV-1 and contraceptive research ^[1].

HY-125810

4'-Ethynyl-2'-deoxyadenosine	HIV Reverse Transcriptase	Infection Inflammation/Immunology
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC₅₀ of 98 nM in MT-4 cells for anti-HIV-1 activity ^[1]. 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-12687R

Tizoxanide (Standard) TIZ (Standard)	Reference Standards Bacterial HIV Autophagy Parasite IKK Influenza Virus	Infection Cancer
Tizoxanide (Standard) is the analytical standard of Tizoxanide. This product is intended for research and analytical applications. Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide *anti-infective* compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has *anti-HIV-1* activities and potent inhibition of both HBV and HCV replication with values EC₅₀ of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells ^[1] .

HY-179348

DPP9-IN-2	Dipeptidyl Peptidase HIV Pyroptosis	Cancer
DPP9-IN-2 is a selective, potent and orally active inhibitor of Dipeptidyl Peptidase 9 (DPP9 ) with an IC₅₀ of 12.9 nM. DPP9-IN-2 shows a SI of 59 over DPP8, and shows no significant inhibitory activity against related peptidases including DPP2, DPP4, FAP, and PREP. DPP9-IN-2 can induce cancer cells pyroptosis and has weak synergistic *anti-HIV-1* activity when combined with non-nucleoside reverse transcriptase inhibitor. DPP9-IN-2 can be used for the researches of cance rand infection ^[1].

HY-N12345

5-Dexyexcoecafolin B	Others	Others
5-Dexyexcoecafolin B is a tigliane-type diterpenoid isolated from the EtOAc extract of Excoecaria acerifolia Didr. 5-Dexyexcoecafolin B has anti-HIV-1 activity with a EC₅₀ value of 0.036 μM ^[1].

HY-P1757

HIV p17 Gag (77-85)	HIV	Infection
HIV p17 Gag (77-85) is an HLA-A0201(A2)-restricted CTL epitope, used in the research of anti-HIV .*

HY-147650

HIV-1 protease-IN-5	HIV Protease	Infection
HIV-1 protease-IN-5 (Compound 13c) is a HIV-1 protease inhibitor with an IC₅₀ of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants ^[1].

HY-116469

ZP7	HIV	Infection
ZP7 (compound 7c) is a potent anti-HIV-1 agent with an EC₅₀ of 36.4nM. ZP7 can be utilized in HIV-1 research ^[1].

HY-172603

HIV-1-IN-82	HIV	Infection
HIV-1-IN-82 (Compound L14) is an orally active small-molecule entry inhibitor for *HIV-1* with an IC₅₀ value of 0.39 μM. HIV-1 inhibitor-82 is promising for research of anti-HIV-1 infection ^[1].

HY-N3094

Periglaucine A	HBV HIV	Infection
Periglaucine A, a hasubanane-type alkaloid, can be isolated from Pericampylus glaucus. Periglaucine A can inhibits HBV surface antigen (HBsAg) secretion in Hep G2.2.15 cells. Periglaucine A also shows anti-HIV-1 activity in C8166 cells (EC₅₀: 204 μM) ^[1].

HY-144731

gp120-IN-2	HIV	Inflammation/Immunology
gp120-IN-2 (compound 4i) is a potent HIV-1 gp120 inhibitor with an IC₅₀ of 7.5 µM and CC₅₀ of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells ^[1].

HY-107003

Opaviraline GW420867X	HIV Protease	Infection
Opaviraline (GW420867X) is an anti-HIV-1 reverse transcriptase inhibitor ^[1].

Cat. No.	상품명	Target	Research Area

HY-P0052

Enfuvirtide 4 Publications Verification T20; DP178	HIV	Infection
Enfuvirtide (T20;DP178) is an anti-HIV-1 fusion inhibitor peptide.

HY-P0052A

Enfuvirtide acetate 4 Publications Verification T20 acetate; DP178 acetate	HIV	Infection
Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.

HY-P1586

HIV-1 Rev (34-50) HIV-1 rev Protein (34-50)	HIV	Infection
HIV-1 Rev (34-50) is a 17-aa peptide derived from the Rev-responsive element (RRE)-binding domains of Rev in HIV-1, with anti-HIV-1 activity.

HY-P1757

HIV p17 Gag (77-85)	HIV	Infection
HIV p17 Gag (77-85) is an HLA-A0201(A2)-restricted CTL epitope, used in the research of anti-HIV .*

HY-P11037

soVIRIP	HIV	Infection
soVIRIP is a virus inhibitory peptide with an IC₅₀ of 1.2  μM for HIV-1 . soVIRIP binds to the HIV-1 GP41 fusion peptide and inhibits viral fusion and entry into host cells. soVIRIP has broad-spectrum anti-HIV-1 activities with nontoxicity in zebrafish models. soVIRIP can used for viral infections research ^[1].

Cat. No.	상품명	Target	Research Area	Image

HY-P99584

Suvizumab KD-247	HIV	Infection
Suvizumab (KD-247) is an neutralizing antibody anti-HIV-1. Suvizumab effectively neutralizes HIV-1_MN, HIV-1_SF2 and HIV-1_89.6 with IC₅₀ values of 0.1 µg/mL, 1.0 µg/mL and 0.2 µg/mL, respectively. Suvizumab reduces the viral load of HIV. Suvizumab has good tolerance and can be used to prevent HIV infection ^[1] .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-105231

Bryostatin 1 2 Publications Verification	Anti-inflammation/Immunoregulatory Neurological Disease Classification of Application Fields Marine natural products Other marine organisms Disease Research Infection Macrolide Antibiotics Animals Antibiotics Anticancer Inflammation/Immunology Disease Research Fields Source Classification	PKC HIV Bacterial
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of *Munc13-1* and the full-length *Munc13-1* protein with K_is of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties ^[1] .

HY-N2010

Methyl gallate 4 Publications Verification Gallincin; NSC 363001	Infection Cardiovascular Disease Paeonia lactiflora Pall. Classification of Application Fields Phenols Polyphenols Plants Paeoniaceae Disease Research Fields Source Classification	Bacterial HIV Reactive Oxygen Species (ROS)
Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Methyl gallate also has anti-HIV-1 and *HIV-1* enzyme inhibitory activities.

HY-78726

Fosamprenavir 4 Publications Verification Amprenavir phosphate; GW 433908	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate HIV HIV Protease
Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection ^[1] .

HY-17431

Fosamprenavir Calcium Salt 4 Publications Verification GW433908G	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate HIV HIV Protease
Fosamprenavir Calcium Salt (GW433908G) is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir Calcium Salt is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir Calcium Salt can be used for the study of human immunodeficiency virus (HIV-1) infection ^[1] .

HY-N2996

Ganodermanondiol	Infection Triterpenes Microorganisms Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Source Classification	HIV Protease
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum ^[1].Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-N0556

Isoescin IA	Other Terpenoids Infection Aesculus chinensis Bunge Classification of Application Fields Terpenoids Hippocastanaceae Plants Disease Research Fields Source Classification	HIV Protease
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity ^[1].

HY-N0867

13-Oxyingenol-13-dodecanoate	Structural Classification Classification of Application Fields Terpenoids Gramineae Other Diseases Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields Source Classification	HIV ULK Bcl-2 Family
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM ^[1].13-Oxyingenol-dodecanoate can induce the expression of *ULK1* to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis .

HY-N16050

Ethyl salvianolate A Ethyl salvionolate A	Simple Phenylpropanols Labiatae Phenylpropanoids Plants Indigofera kirilowii Maxim. ex Palib Source Classification	HIV Reverse Transcriptase HIV Integrase HIV Protease
Ethyl salvianolate A (Ethyl salvionolate A) is an anti-HIV-1 compound that can be extracted from the roots of Salvia yunnanensis. Ethyl salvianolate A inhibits P24 antigen in HIV-1 infected MT-4 cell cultures (EC₅₀: 1.44 μg/mL). Ethyl salvianolate A inhibits HIV-1 replicative enzymes, with IC₅₀s of 56.38 μM (Reverse transcriptase), 12.03 μM (Protease), 14.54 μM (Integrase), respectively ^[1].

HY-N12046

Schineolignin B	Monophenols Phenols Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Source Classification	HIV
Schineolignin B is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities ^[1].

HY-N10958

Wikstrol A	Flavonols Flavonoids Microorganisms Source Classification	Fungal HIV Microtubule/Tubulin
Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC₅₀ value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC₅₀ value of 67.8 µM ^[1].

HY-113818

Kadsuracoccinic acid A	Natural Products Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae Source Classification	HIV
Kadsuracoccinic acid A is a tetracyclic natural compound that can be isolated from the stems of Kadsura coccinea. Kadsuracoccinic acid A has vitro *anti-HIV-1* activitiy with an EC₅₀ value of 68.7 μM ^[1].

HY-N3502

20(21)-Dehydrolucidenic acid A	Infection Triterpenes Classification of Application Fields Terpenoids Polyporaceae Plants Disease Research Fields Source Classification	HIV Protease
20(21)-Dehydrolucidenic acid A is a triterpenoid isolated from the fruiting body of the fungus Ganoderma sinense. 20(21)-Dehydrolucidenic acid A has weak anti-HIV-1 protease activity ^[1].

HY-N0556R

Isoescin IA (Standard)	Other Terpenoids Aesculus chinensis Bunge Structural Classification Terpenoids Hippocastanaceae Plants Source Classification	Reference Standards HIV Protease
Isoescin IA (Standard) is the analytical standard of Isoescin IA. This product is intended for research and analytical applications. Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity ^[1].

HY-N12345

5-Dexyexcoecafolin B	Triterpenes Excoecaria acertiflia Didr Terpenoids Euphorbiaceae Plants Source Classification	Others
5-Dexyexcoecafolin B is a tigliane-type diterpenoid isolated from the EtOAc extract of Excoecaria acerifolia Didr. 5-Dexyexcoecafolin B has anti-HIV-1 activity with a EC₅₀ value of 0.036 μM ^[1].

HY-N3094

Periglaucine A	Alkaloids Pyrrole Alkaloids Labiatae Ulex europaeus L. Plants Source Classification	HBV HIV
Periglaucine A, a hasubanane-type alkaloid, can be isolated from Pericampylus glaucus. Periglaucine A can inhibits HBV surface antigen (HBsAg) secretion in Hep G2.2.15 cells. Periglaucine A also shows anti-HIV-1 activity in C8166 cells (EC₅₀: 204 μM) ^[1].

HY-N1352

Rhuscholide A	Natural Products Monophenols Rhus chinensis Mill. Phenols Plants Anacardiaceae Source Classification	HIV
Rhuscholide A is a benzofuran lactone that shows significant anti-HIV-1 activity, with an EC₅₀ of 1.62 μM ^[1].

HY-N12047

Schineolignin C	Phenols Polyphenols Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Source Classification	HIV
Schineolignin C is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities ^[1].

HY-N10934

Ganoderic acid GS-1	Triterpenes Microorganisms Terpenoids Source Classification	HIV Protease
Ganoderic acid GS-1, a highly oxygenated lanostane-type triterpenoid, has anti-HIV-1 protease activities with an IC₅₀ of 58 μM ^[1].

HY-116529

Lamellarin E	Alkaloids Microorganisms Other Alkaloids Source Classification	Others
Lamellarin E is a biologically active marine alkaloid, while the Lamellarin series of alkaloids show potential cytotoxicity, topoisomerase I inhibition, protein kinase inhibition, multidrug resistance reversal, and anti-HIV-1 activity ^[1].

HY-W707365

Docosyl trans-ferulate	Monophenols Zingiber mekongense Gagnep. Phenols Plants Source Classification Zingiberaceae	HIV
Docosyl trans-ferulate (compound 2) is an antiviral compound. Docosyl trans-ferulate exhibits anti-HIV-1 activity in anti-syncytial assays using the ^ΔTat/revMC99 virus and 1A2 cell line systems ^[1].

HY-N10801

Salvianan A	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Magnoliaceae Phenols Diterpenoids Plants Source Classification	HIV
1,6,11-Trimethyl-1,2-dihydrofuro[2',3':1,2]phenanthro[4,3-d]oxazole (compound 1) is a potent *anti-HIV-1* agent ^[1].

HY-N2010R

Methyl gallate (Standard) Gallincin (Standard); NSC 363001 (Standard)	Structural Classification Paeonia lactiflora Pall. Phenols Polyphenols Plants Paeoniaceae Source Classification	Reference Standards Bacterial HIV Reactive Oxygen Species (ROS)
Methyl gallate (Standard) is the analytical standard of Methyl gallate. This product is intended for research and analytical applications. Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Methyl gallate also has anti-HIV-1 and HIV-1 enzyme inhibitory activities.

HY-17431R

Fosamprenavir Calcium Salt (Standard) GW433908G (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Drug Intermediate HIV HIV Protease
Fosamprenavir Calcium Salt (GW433908G) (Standard) is the analytical standard of Fosamprenavir Calcium Salt (HY-17431R). This product is intended for research and analytical applications. Fosamprenavir Calcium Salt (GW433908G) is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir Calcium Salt is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir Calcium Salt can be used for the study of human immunodeficiency virus (HIV-1) infection ^[1] .

HY-N1111

Uncaric acid 6β,19α-Dihydroxyursolic acid	Triterpenes Terpenoids Rosaceae Plants Eriobotrya japonica (Thunb.) Lindl. Source Classification	HIV
Uncaric acid (6β,19α-Dihydroxyursolic acid) (compound 6) is a triterpene that can be found in Eriobotrya japonica. Uncaric acid shows anti HIV-1, HRV 1B, SNV activity ^[1].

HY-N17741

Melanochromone	Structural Classification Coumarins Phenylpropanoids Plants Moraceae Source Classification	HIV Reverse Transcriptase
Melanochromone is an HIV-1 reverse transcriptase inhibitor that exhibits anti-HIV-1 activity. Melanochromone can be used in research related to HIV-1 infection ^[1].

HY-N11288

Methyl salvionolate A	Labiatae Phenols Polyphenols Plants Indigofera kirilowii Maxim. ex Palib Source Classification	HIV
Methyl salvionolate A is a potent inhibitor of *HIV-1. Methyl salvionolate A inhibits P24* antigen in HIV-1 infected MT-4 cell with an EC₅₀ of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC₅₀s of 50.58, 10.73 and 7.58 μg/ml, respectively ^[1].

HY-116931

Kelletinin I	Animals Phenols Polyphenols Source Classification	Others
Kelletinin I is a coumarin compound with anti-HIV-1 activity.

HY-N13863

Glepidotin A	Structural Classification Flavonols Flavonoids Leguminosae Plants Glycyrrhiza lepidota Pursh Source Classification	Others
Glepidotin A is a flavanol. Glepidotin A can be isolated from the leaves and stems of Glycyrrhiza lepidota. Glepidotin A exhibits no anti-HIV-1 activity ^[1].

HY-N19826

Lancifodilactone N	Schisandra lancifolia (Rehd. et Wils.) A. C. Smith Triterpenes Structural Classification Terpenoids Plants Schisandraceae Source Classification	HIV
Lancifodilactone N is a nortriterpenoid found in the leaves and stems of Schisandra lancifolia. Lancifodilactone N shows anti-HIV-1 activity and can be used for the research of HIV-1 infection ^[1].

HY-N19685

3β-Hydroxy sandaracopimaric acid	Structural Classification Cupressaceae Ketones, Aldehydes, Acids Plants Juniperus occidentalis Hook. Source Classification	Drug Derivative
3β-Hydroxy sandaracopimaric acid is a diterpene found in the leaves of Juniperus occidentalis with no significant anti-HIV-1 activity.3β-Hydroxy sandaracopimaric acid does not inhibit HIV-1 replication ^[1].

HY-N16821

Hydroxydihydrobovolide	Structural Classification Terpenoids Sesquiterpenes Myrtaceae Rhodomyrtus tomentosa Plants Source Classification	HIV
Hydroxydihydrobovolide is a α-β-unsaturatedγ-lactone found in Portulaca oleracea L.. Hydroxydihydrobovolide shows cytotoxicity against cancer cells and shows anti-HIV-1 activity (IC₅₀ = 122.7 μM). Hydroxydihydrobovolide can be used for the researches of neuroblastoma and HIV-1 infection ^[1].

HY-N17718

Urushiol (15:3) 3-[8'(Z), 11'(Z), 14'-Pentadecatrienyl] catechol	Structural Classification Phenols Polyphenols Plants Toxicodendron vernicifluum (Stokes) F. A. Barkl. Anacardiaceae Source Classification	HIV Reverse Transcriptase
Ursolic acid (15:3) (Compound 4) is a type of resiniferatoxin compound that can be found in the leaves of the tree Rhus verniciflua. Ursolic acid (15:3) exhibits moderate inhibitory activity against HIV-1 reverse transcriptase (b HIV-1 reverse transcriptase), with an IC₅₀ value of 55.36 μM. Ursolic acid (15:3) shows strong cytotoxicity against both PC-3 and MRC-5 cells. Ursolic acid (15:3) can be used in the research of anti-HIV-1 infection and prostate cancer ^[1].

Cat. No.	상품명	Chemical Structure

HY-78726S

Fosamprenavir-d4

Fosamprenavir-d₄ is the Deuterium-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection ^[1] .

HY-12687S

Tizoxanide-d4
Tizoxanide-d₄ is the deuterium labeled Tizoxanide. Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities ^[1] .

HY-78726S2

Fosamprenavir-13C6

Fosamprenavir- ¹³C₆ is the ¹³C-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection ^[1] .

Cat. No.	상품명		Classification