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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
Ark5
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "Ark5" in MCE Product Catalog:
8
8 Publications Verification
WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1 (ARK5)/NUAK2, without significant inhibition on other 139 kinases.
2
Narazaciclib (ON123300), a strong and brain-penetrant multi-kinase inhibitor, inhibits CDK4 (IC50=3.9 nM), Ark5 (IC50=5 nM), PDGFRβ (IC50=26 nM), FGFR1 (IC50=26 nM), RET (IC50=9.2 nM), and FYN (IC50=11 nM). Single agent Narazaciclib causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors . Narazaciclib inhibits CDK6 with an IC50 of 9.82 nM .
1
1 Cited Publications
HTH-01-015 is a selective NUAK1/ARK5 inhibitor (IC50 is 100 nM). HTH-01-015 inhibits NUAK1 with >100-fold higher potency than NUAK2 (IC50 of >10 μM).
Cat. No.: HY-E70850
NuaK1 (ARK5) is a downstream effector of Akt and is activated in response to cellular hypoxia and nutrient starvation. NuaK1(ARK5) Recombinant Human Active Protein Kinase is a recombinant NuaK1(ARK5) protein that can be used to study NuaK1(ARK5)-related functions .
Cat. No.: HY-N3634
CAS No.: 775351-91-2
Target:
Cat. No.: HY-RS09644
Target:
Research Areas:
NUAK1 Human Pre-designed siRNA Set A contains three designed siRNAs for NUAK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P706003
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: NUAK1; NUAK Family SNF1-Like Kinase 1; NUAK Family Kinase 1; AMPK-Related Protein Kinase 5; Ark5; Omphalocele Kinase 1; KIAA0537; Non-Specific Serine/Threonine Protein Kinase; AMP-Activated Protein Kinase Family Member 5; OMPHK1; NUAK Family, SNF1-Like Ki
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
