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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
61 Results for "
BEAS-2B
" in MedChemExpress (MCE) Product Catalog:
Products (61)
61 Results for "BEAS-2B" in MCE Product Catalog:
33
33 Publications Verification
Synonyms: EPZ015938
GSK3326595 is a protein arginine methyltransferase 5 (PRMT5) inhibitor. GSK3326595 decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. GSK3326595 can be used for research of relapsed/refractory mantle cell lymphoma [2] .
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23 Cited Publications
Target:
연구분야:
KI696 is a selective KEAP1/NRF2 protein-protein interaction inhibitor with a human Kd value of 1.3 nM. KI696 acts by competitively occupying the NRF2-binding pocket of the KEAP1 Kelch domain. KI696 blocks KEAP1-mediated ubiquitination and degradation of NRF2, promotes the translocation of NRF2 to the nucleus, activates the expression of downstream antioxidant genes, increases intracellular glutathione levels, and alleviates oxidative stress-induced cell damage and inflammatory cell infiltration in the lungs. KI696 reduces ozone-induced pulmonary oxidative damage and inflammatory cell accumulation in rats, and upregulates pulmonary antioxidant genes. KI696 can be used in research related to chronic obstructive pulmonary disease, oxidative stress and inflammation .
4
4
Category:
Flavonoids Leguminosae Flavonones Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Cancer
Target:
3
3 Cited Publications
Synonyms: TAS6417; CLN-081
Zipalertinib (TAS6417; CLN-081) is a highly effective, orally active and pan-mutation-selective EGFR tyrosine kinase inhibitor with a unique scaffold fitting into the ATP-binding site of the EGFR hinge region, with IC50 values ranging from 1.1-8.0 nM [2].
2
2
2 Cited Publications
Synonyms: OPC 2009 hydrochloride hemihydrate
Target:
Procaterol hydrochloride hemihydrate is an orally active β2 adrenoreceptor agonist. Procaterol hydrochloride hemihydrate can be used for the research of asthma [2] .
1
1 Cited Publications
Cat. No.: HY-N2440
CAS No.: 157752-01-7
1
연구분야:
Prometryn is a triazine herbicide. Prometryn induces apoptosis and cell cycle arrest. Prometryn induces oxidative stress, DNA damage and autophagy-related gene expression, and non-specific immunity gene expression. Prometryn can be used for the research of herbicide, hepatopancreas injury, and intestinal stress and intestinal barrier dysfunction [2] .
Target:
연구분야:
STAT6-IN-3 is a phosphopeptide mimic targeting the SH2 domain of STAT6 and has a high affinity for STAT6 (IC50: 0.04 μM). STAT6-IN-3 can be used in the research of inflammation such as asthma .
Category:
Other Terpenoids Capsicum annuum L. other families Neurological Disease Terpenoids Plants Solanaceae Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-P991280
Target:
연구분야:
Cat. No.: HY-N0412
CAS No.: 117479-87-5
Category:
Iridoids Labiatae Terpenoids Phaseolus lunatus L. Plants Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-W016969
CAS No.: 112-12-9
Target:
연구분야:
STAT6-IN-2 (Compound R-84) is a STAT6 inhibitor that can inhibit the tyrosine phosphorylation of STAT6. STAT6-IN-2 can also inhibit the secretion of eotaxin-3. STAT6-IN-2 can be used in the research of immune diseases and allergic inflammatory diseases such as asthma .
Target:
PM-43I is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research [1].
Target:
SR 16832 is a dual-site covalent, orthosteric and allosteric PPARγ antagonist. SR 16832 activates the TGF-β signaling pathway and upregulates the expression of Vimentin and Fibronectin (Fibronectin). SR 16832 is toxic to bronchial epithelium. SR 16832 can be used in research related to type 2 diabetes and pulmonary fibrosis [2].
Target:
연구분야:
KI696 isomer is an isomer of KI696 (HY-101140). KI696 is a selective KEAP1/NRF2 protein-protein interaction inhibitor with a human Kd value of 1.3 nM. KI696 acts by competitively occupying the NRF2-binding pocket of the KEAP1 Kelch domain. KI696 blocks KEAP1-mediated ubiquitination and degradation of NRF2, promotes the translocation of NRF2 to the nucleus, activates the expression of downstream antioxidant genes, increases intracellular glutathione levels, and alleviates oxidative stress-induced cell damage and inflammatory cell infiltration in the lungs. KI696 reduces ozone-induced pulmonary oxidative damage and inflammatory cell accumulation in rats, and upregulates pulmonary antioxidant genes. KI696 can be used in research related to chronic obstructive pulmonary disease, oxidative stress and inflammation .
Cat. No.: HY-172910
CAS No.: 3077252-76-4
연구분야:
MTHFD2-IN-6 is an orally active selective inhibitor of MTHFD2, with a human IC50 of 1.46 μM. MTHFD2-IN-6 binds directly to MTHFD2, selectively inhibits cancer cell proliferation, promotes ROS accumulation in cancer cells, and induces cancer cell cycle arrest and apoptosis. MTHFD2-IN-6 inhibits tumor growth in Mus musculus xenograft models. MTHFD2-IN-6 can be used for lung cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
