1 Result for "

BTCA

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "BTCA" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-33299
CAS No.: 154235-77-5
Synonyms: BTCA
Research Areas:  

Cancer

Serpin B9-IN-1 (BTCA) is an inhibitor that specifically targets Serpin B9 (SB9); SB9 is a natural inhibitor of granzyme B (GrB) , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery (CA) mouse model (LCBM) .
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