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Bleximenib

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-148669
    Bleximenib
    1 Publications Verification

    JNJ-75276617; Menin-MLL inhibitor 24

    		 Apoptosis Histone Methyltransferase FLT3 Cancer
    Bleximenib (JNJ-75276617) is an orally active and selective menin-KMT2A inhibitor, with IC50 values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. Bleximenib can inhibit the proliferation and induce apoptosis and differentiation of tumor cells. Bleximenib can be used in the research of tumors such as leukemia .
    Bleximenib
  • HY-148669A
    Bleximenib oxalate
    1 Publications Verification

    JNJ-75276617 oxalate; Menin-MLL inhibitor 24 oxalate

    		 Apoptosis Histone Methyltransferase FLT3 Cancer
    Bleximenib (JNJ-75276617) oxalate is an orally active and selective menin-KMT2A inhibitor, with IC50 values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. Bleximenib oxalate can inhibit the proliferation and induce apoptosis and differentiation of tumor cells. Bleximenib oxalate can be used in the research of tumors such as leukemia .
    Bleximenib oxalate
  • HY-148669B
    (S)-Bleximenib oxalate

    (S)-JNJ-75276617 oxalate; (S)-Menin-MLL inhibitor 24 oxalate

    		 Apoptosis Histone Methyltransferase FLT3 Cancer
    (S)-Bleximenib (oxalate) is a S-Enantiomer of Bleximenib oxalate (HY-148669A). Bleximenib (JNJ-75276617) oxalate is an orally active and selective menin-KMT2A inhibitor, with IC50 values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. Bleximenib oxalate can inhibit the proliferation and induce apoptosis and differentiation of tumor cells. Bleximenib oxalate can be used in the research of tumors such as leukemia .
    (S)-Bleximenib oxalate
  • HY-155797
    (S)-Bleximenib

    (S)-JNJ-75276617; (S)-Menin-MLL inhibitor 24

    		 Drug Isomer HOXA Cancer
    (S)-Bleximenib (Compound 28) ((S)-JNJ-75276617) is an isoform of Bleximenib (HY-148669). (S)-Bleximenib shows an IC50 greater than 1 μM in the MEIS1 mRNA expression assay. (S)-Bleximenib can be used in the research of acute myeloid leukemia .
    (S)-Bleximenib

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