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C. elegans

" in MedChemExpress (MCE) Product Catalog:

26

Inhibitors & Agonists

12

Natural
Products

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-145376

    CAI-1

    Others Others
    Cholera autoinducer 1 is Vibrio cholerae autoinducer (S)-3-hydroxytridecan-4-one. Cholera autoinducer 1 influences chemotaxis in C. elegans .
    Cholera autoinducer 1
  • HY-141894

    Others Others
    5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA analog. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation .
    5-Ph-IAA-AM
  • HY-N12887

    Mitochondrial Metabolism Others Cancer
    Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC50 is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans .
    Mycothiazole
  • HY-125134

    Parasite Inflammation/Immunology
    Alloaromadendrene, an antioxidant, can be isolated from the leaves of mixed-type C. osmophloeum. Alloaromadendrene protects C. elegans against oxidative stress induced by walnut quinone and prolongs the life of C. elegans .
    Alloaromadendrene
  • HY-147644

    Others Neurological Disease
    α-Synuclein inhibitor 3 (Compound 7g) is a α-synuclein (α -Syn) aggregation inhibitor. α-Synuclein inhibitor 3 can be used for Parkinson’s disease research .
    α-Synuclein inhibitor 3
  • HY-P2779

    Endogenous Metabolite Metabolic Disease
    Microsomal aminopeptidase, Microorganism is first reported from C. elegans. The Microsomal aminopeptidase, Microorganism is beneficial for the development of molecular vaccines against parasitic nematodes .
    Microsomal aminopeptidase, Microorganism
  • HY-120620

    Others Others
    BMS-195270 is a small molecule that inhibits Carbachol (HY-B1208)-evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux .
    BMS-195270
  • HY-N12486

    Keap1-Nrf2 ATP Synthase Metabolic Disease
    Isofalcarintriol is a NRF2 activator and selective inhibitor of the mitochondrial ATP synthase. Isofalcarintriol can be used for aging study .
    Isofalcarintriol
  • HY-N12722

    Others Others
    Ophiocordylongiiside A is a compound found in Polyphilus sieberi. Ophiocordylongiiside A shows activity against the free-living nematode Caenorhabditis elegans .
    Ophiocordylongiiside A
  • HY-N2149
    Tomatidine
    5 Publications Verification

    NF-κB JNK Autophagy Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology
    Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine activates autophagy either in mammal cells or C elegans .
    Tomatidine
  • HY-N2149A
    Tomatidine hydrochloride
    5 Publications Verification

    NF-κB JNK Autophagy Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology
    Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans .
    Tomatidine hydrochloride
  • HY-162297

    Others Others
    4-(Sulfooxy)benzoic acid is a sulfated phenolic acid found in C. elegans. 4-(Sulfooxy)benzoic acid is a metabolite of ethyl para-hydroxybenzoate and several flavonoids .
    4-(Sulfooxy)benzoic acid
  • HY-125731

    Endogenous Metabolite STAT Autophagy Inflammation/Immunology Cancer
    Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .
    Glycodeoxycholic Acid
  • HY-W035409
    RPW-24
    1 Publications Verification

    Bacterial Infection
    RPW-24 protects C. elegans from bacterial infection by stimulating the host immune response of the nematode. RPW-24 has antibacterial activity .
    RPW-24
  • HY-121152

    α-synuclein Apoptosis GABA Receptor Dopamine Receptor Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Chiisanoside exhibits neuroprotective, anticancer, antidepressant, anti-inflammatory, anti-obesity and anti-platelet activities. Chiisanoside inhibits tumor growth in H22 xenograft mouse model, through immunoregulation, induction of apoptosis and inhibition of angiogenesis. Chiisanoside attenuates Parkinson’s disease through regulation of Parkin/ZNF746/PGC-1α axis, and promotion of mitochondrial biogenesis .
    Chiisanoside
  • HY-123265

    Griseulin

    Bacterial Infection
    Luteoreticulin is a nitro-containing bacterial metabolite originally isolated from S. luteoreticuli. It has mosquitocidal activity against A. aegypti when used at a concentration of 6.25 mg/L and nematocidal activity against C. elegans.
    Luteoreticulin
  • HY-161163

    AMPK Neurological Disease
    IND 1316 is an orally active, blood-brain barrier permeable AMPK activator with neuroprotective effects in animal models of Huntington's disease. IND 1316 can be used for research on neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease .
    IND 1316
  • HY-N12526

    Others Others
    Isolappaol A is a natural product that can be isolated from the Arctium lappa. Isolappaol A upregulates the expression of jnk-1, which may promote longevity and stress resistance of C. elegans through the JNK-1-DAF-16 cascade .
    Isolappaol A
  • HY-116498

    Others Infection
    Penigequinolone A is an alkaloid isolated from Penicillium. It is lethal to P. penetrans (LD50=100 mg/L) but has no effect on C. elegans at concentrations up to 1000 mg/L.1 Penigequinolone A also accelerates the root growth of rice seedlings in a dose-dependent manner.
    Penigequinolone A
  • HY-133859

    Mitochondrial Metabolism Metabolic Disease
    M084 is a benzimidazole derivative. M084 inhibits the mitochondrial respiration, activate mitochondrial unfolded protein response and AMPK, recruites SIR-2.1 and SKN-1, and finally through the transcription factor DAF-16, delays the aging process of C. elegans .
    M084
  • HY-123693

    Others Inflammation/Immunology
    ML358 is a first in class, potent, and selective inhibitor of the SKN-1 pathway (IC50=0.24 μM). ML358 sensitizes the model nematode C. elegans to oxidants and anthelmintic. ML358 potentially used as adjuvants to increase the efficacy and useful life of current anthelmintics .
    ML358
  • HY-161404

    Bacterial Infection
    Antibacterial agent 202 (compound 45c) is a low cytotoxic bacterial inhibitor with good activity against Gram-negative bacteria, including Escherichia coli, Klebsiella pneumonia, especially Pseudomonas aeruginosa, (MIC (minimum inhibitory concentration)=7.8-31.25 μM). Antibacterial agent 202 can exert antibacterial activity by destroying the integrity of cell membranes and can be used in the research of bacterial infections .
    Antibacterial agent 202
  • HY-163473

    Bacterial Infection
    IITR08367 is a potent effector pump Acinetobacter baumannii Fosfomycin Efflux pump (AbaF) inhibitor for enhancing the antimicrobial activity of Fosfomycin (HY-B1075A) against Acinetobacter baumannii. IITR08367 acts by interfering with Fosfomycin/H + reverse transporter activity. .
    IITR08367
  • HY-130431

    Parasite Infection
    Vinclozolin M2 is an active metabolite of vinclozolin. It is formed from vinclozolin by successive esterase activity and decarboxylation of vinclozolin in C. elegans and by decarboxylation in human liver microsomes. Vinclozolin M2 is an antagonist of the mineralocorticoid receptor (IC50=1,400 nM) and androgen receptor (IC50=0.17 nM) in reporter assays using MCF-7 cells.
    Vinclozolin M2
  • HY-W592871

    10-HDA

    mTOR Cardiovascular Disease Inflammation/Immunology Cancer
    10-Hydroxy-2-decenoic acid (10-HDA) is the major lipid component of royal jelly produced by honeybees. 10-Hydroxy-2-decenoic acid has several health-beneficial effects in mammals, such as antitumor activity, anti-inflammatory activity, and antiangiogenic activity. 10-Hydroxy-2-decenoic acid also extends the lifespan of C. elegans .
    10-Hydroxy-2-decenoic acid
  • HY-W643167

    Glycerol Tritridecanoyl; 13:0 TAG; 13:0/13:0/13:0-TG

    Others Infection
    1,2,3-Tritridecanoyl glycerol is a synthetic triacylglycerol that contains tridecanoic acid in the sn-1, sn-2, and sn-3 positions. It has been used as a standard for the relative quantification of triacylglycerols in C. elegans fat stores. It has also been used as an internal standard for the quantification of triacylglycerols in the serum and liver of adult rat offspring receiving dietary conjugated linoleic acids during and after gestation.
    1,2,3-Tritridecanoylglycerol

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