96 Results for "

C. elegans

" in MedChemExpress (MCE) Product Catalog:
Products (96)

96 Results for "C. elegans" in MCE Product Catalog:

10
10 Publications Verification
Cat. No.: HY-N2149
CAS No.: 77-59-8
Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine activates autophagy either in mammal cells or C elegans .
loading...
    loading...
10
10 Publications Verification
Cat. No.: HY-N2149A
CAS No.: 6192-62-7
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans .
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-125731
CAS No.: 360-65-6
Purity:  99.08%
Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-B0512
CAS No.: 127-79-7
Synonyms: RP2632
Sulfamerazine (RP2632) is a brain-penetrant and orally active sulfonamide antibiotic and α-synuclein inhibitor with human α-synuclein KD of 352 μM. Sulfamerazine inhibits the synthesis of dihydrofolate by bacteria, thereby inhibiting bacterial growth. Sulfamerazine inhibits α-synuclein fibrillation, reduces α-synuclein aggregation-associated toxicity and α-synuclein aggregate accumulation. Sulfamerazine can be used for the research of Parkinson’s disease and bacterial infection .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-141894
CAS No.: 2990123-10-7
Purity:  99.04%
Research Areas:  

Metabolic Disease

5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA (HY-134653) analog which contains an acetoxymethyl (AM) group. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-W592871
CAS No.: 765-01-5
Synonyms: 10-HDA; Queen Bee Acid
10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-N4099
CAS No.: 53527-42-7
Luteolin-3-O-beta-D-glucuronide, a glucuronide derivative of Luteolin (HY-N0162), is found in the leaves of Rosmarinus officinalis L. Luteolin-3-O-beta-D-glucuronide inhibits nitrite production in macrophages and binds strongly to FYN kinase .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-N0309
CAS No.: 114590-20-4
Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-W035409
CAS No.: 1001625-82-6
Target:  

Bacterial

Research Areas:  

Infection

RPW-24 protects C. elegans from bacterial infection by stimulating the host immune response of the nematode. RPW-24 has antibacterial activity .
loading...
    loading...
Cat. No.: HY-W015924
CAS No.: 594-61-6
2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].
loading...
    loading...
Cat. No.: HY-N0059
CAS No.: 10323-20-3
D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .
loading...
    loading...
Cat. No.: HY-170794
CAS No.: 2035010-37-6
Research Areas:  

Metabolic Disease

ALT-007 is an orally active serine palmitoyltransferase (SPT) inhibitor that selectively reduces the levels of toxic very-long-chain deoxysphingolipids to enhance protein homeostasis. ALT-007 restores aging-related loss of muscle mass in a mouse model of sarcopenia. ALT-007 enhances protein homeostasis in both mouse and C. elegans models of aging and disease. ALT-007 can be used for age-related neuromuscular diseases research .
loading...
    loading...
Cat. No.: HY-N7082
CAS No.: 28697-53-2
D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .
loading...
    loading...
Cat. No.: HY-P2779
CAS No.: 9054-63-1
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

Microsomal aminopeptidase, Microorganism is first reported from C. elegans. The Microsomal aminopeptidase, Microorganism is beneficial for the development of molecular vaccines against parasitic nematodes .
loading...
    loading...
Cat. No.: HY-N6974
CAS No.: 946524-24-9
Synonyms: Ascaroside C6
Ascr#2 (Ascaroside C6) is an ascaroside isolated from Caenorhabditis elegans, potently promotes dauer formation, and also acts as a potent male attractant combined with Ascr#3 (HY-N6977) at low concentration .
loading...
    loading...
Cat. No.: HY-P4344
CAS No.: 1926163-52-1
Met-Gly-Pro-AMC is a fluorescent peptide substrate active against *Caenorhabditis elegans* DPF-3, hDPP4, and methionyl aminopeptidase 2 (MetAP2). Met-Gly-Pro-AMC undergoes cleavage via tripeptidyl peptidase activity to release a fluorescent product. Met-Gly-Pro-AMC is used to detect the activities of tripeptidyl peptidases and MetAP2 peptidases in in vitro enzyme activity assays .
loading...
    loading...
Cat. No.: HY-113286
CAS No.: 463-00-3
Purity:  ≥98.0%
4-Guanidinobutanoic acid is a metabolite of arginine and an orally active SLC36A1/Hedgehog signaling pathway activator. 4-Guanidinobutanoic acid drives epithelial reprogramming, enhances intestinal stem cell function and goblet cell differentiation. 4-Guanidinobutanoic acid promotes the enrichment of Akkermansia muciniphila via mucus-dependent niche expansion, regulates intestinal homeostasis, and establishes a microbiota-host feedback loop. 4-Guanidinobutanoic acid exhibits anti-aging and healthspan-regulating properties. 4-Guanidinobutanoic acid can be used in research related to ulcerative colitis, amyotrophic lateral sclerosis, and Duchenne muscular dystrophy .
loading...
    loading...
Cat. No.: HY-145376
CAS No.: 1004296-82-5
Purity:  99.32%
Synonyms: CAI-1
Target:  

Bacterial

Research Areas:  

Others

Cholera autoinducer 1 is Vibrio cholerae autoinducer (S)-3-hydroxytridecan-4-one. Cholera autoinducer 1 influences chemotaxis in C. elegans .
loading...
    loading...
Cat. No.: HY-121811
CAS No.: 484-33-3
Purity:  99.81%
Synonyms: Lanceolatin C
Pongamol (Lanceolatin C) is an orally active flavonoid with an IC50 of 75 μM and a Ki of 58 μM against PTPase-1B, and an IC50 of 103.5 μM against intestinal α-Glycosidase. Pongamol reduces the release of IL‑1β, TNF‑α, COX‑2 and iNOS in cells, reverses the nuclear translocation of NF‑κB, and upregulates the levels of Beclin 1 and LC3 Ⅱ/LC3 Ⅰ. Pongamol promotes glucose uptake by increasing the level of GLUT4 on the surface of skeletal muscle cells. Pongamol inhibits epithelial-mesenchymal transition by suppressing the FAK/Akt-mTOR signaling pathway. Pongamol inhibits neuronal cytotoxicity, suppresses cell apoptosis and extends the lifespan of Caenorhabditis elegans by activating the MAPKs/Nrf2 signaling pathway. Pongamol exerts hypoglycemic effects in diabetic mouse models. Pongamol exhibits antibacterial activity. Pongamol alleviates oxidative stress, neuroinflammation, deposition and excessive phosphorylation of Tau Protein, and restores autophagy function in Alzheimer's disease mouse models by inhibiting the Akt/mTOR signaling pathway. Pongamol is applicable to research related to Alzheimer's disease, type 2 diabetes, non-small cell lung cancer and postprandial hyperglycemia .
loading...
    loading...
Cat. No.: HY-N7107
CAS No.: 1632-73-1
Fenchyl alcohol is a monoterpene alcohol that can be used as a fragrance. Fenchyl alcohol has antifungal activity and can inhibit the formation of biofilms and hyphae of Candida albicans. Fenchyl alcohol also has a strong inhibitory effect on the rumen microbial activity of sheep and deer .
loading...
    loading...