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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
CCW-16
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "CCW-16" in MCE Product Catalog:
Forschungsgebiete:
CCW16 is a non-selective cysteine-reactive covalent ligand and an RNF4 E3 ubiquitin ligase recruiter with an IC50 of 1.8 μM against human RNF4[. CCW16 covalently modifies accessible cysteine residues on RNF4, PRDX1, PRDX2, and PRDX6, attenuating the peroxide-scavenging activity of peroxiredoxins. CCW16 induces oxidative stress through upregulation of HMOX1 and NRF2, and triggers ferroptosis via lipid peroxidation and ROS signaling pathways in an RNF4-independent manner. CCW16 serves as an RNF4-recruiting moiety; it does not induce RNF4 degradation when used alone and can be used to synthesize protein degraders, such as the PROTAC compound CCW 28-3 (HY-156774). CCW16 can be used for research on acute myeloid leukemia and hepatocellular carcinoma .
Art. -Nr.: HY-170383
Forschungsgebiete:
CCW16-C4-NHBoc (RNF4 ligand CCW16 (HY-143346)) is an E3 Ligase Ligand-Linker Conjugate for BRD4 PROTAC CCW 28-3 (HY-156774) .
Art. -Nr.: HY-181693
Forschungsgebiete:
CCW16-C2-Boc is a conjugate targeting RNF4, formed by coupling the target protein ligand CCW16 (HY-143346) with a PROTAC Linker. CCW16-C2-Boc can be used to synthesize the PROTAC degrader: PROTAC RNF4 degrader-1 (HY-181693) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
