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CFTR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CFTR (103) Apoptosis (2) Aquaporin (2) Atg8/LC3 (1) Autophagy (29) Calcium Channel (1) Caspase (2) CDK (1) Chloride Channel (11) Deubiquitinase (2) DNA Methyltransferase (1) Drug Isomer (1) DUBTACs (1) E1/E2/E3 Enzyme (2) Elastase (1) Endogenous Metabolite (3) ERK (1) Fluorescent Dye (6) Glutathione Peroxidase (3) GSK-3 (1) GSNOR (2) Isotope-Labeled Compounds (7) JNK (1) Liposome (1) Mitochondrial Metabolism (5) NO Synthase (3) P-glycoprotein (5) PARP (2) Phosphodiesterase (PDE) (1) Potassium Channel (7) PROTACs (1) Reference Standards (11) SARS-CoV (1) Small Interfering RNA (siRNA) (3) TNF Receptor (3) TRP Channel (2)
By Research Areas:	Cancer (17) Cardiovascular Disease (5) Endocrinology (16) Infection (2) Inflammation/Immunology (48) Metabolic Disease (15) Neurological Disease (3)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

122

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: CFTR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13017

Ivacaftor 25+ Cited Publications VX-770	CFTR Autophagy	Endocrinology
Ivacaftor (VX-770) is a potent and orally bioavailable *CFTR* potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively.

HY-15448

Tezacaftor 20+ Cited Publications VX-661	CFTR	Cancer
Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

HY-111772

Elexacaftor Maximum Cited Publications 48 Publications Verification VX-445	CFTR Autophagy	Inflammation/Immunology
Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface .

HY-16671

CFTR(inh)-172 20+ Cited Publications	CFTR Autophagy	Others
CFTR(inh)-172 is a potent and selective blocker of the *CFTR* chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a K_i of 300 nM.

HY-145603

Vanzacaftor 4 Publications Verification VX-121	CFTR Chloride Channel	Neurological Disease
Vanzacaftor (VX-121) is an orally active noval corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves processing and trafficking of *CFTR* protein as well as increases chloride transport in triple combined with Tezacaftor (HY-15448) and Deutivacaftor. Vanzacaftor-Tezacaftor-Deutivacaftor is safe and well tolerated, improving lung function, respiratory symptoms, and *CFTR* function with cystic fibrosis, which is promising for research in the field of cystic fibrosis diseases .

HY-13262

Lumacaftor 15+ Cited Publications VX-809; VRT 826809	CFTR Autophagy	Inflammation/Immunology
Lumacaftor (VX-809; VRT 826809) is a *CFTR* modulator that corrects the folding and trafficking of CFTR protein.

HY-13017S

Ivacaftor-d9 VX-770-d₉	CFTR	Cancer
Ivacaftor-d₉ is a potent CFTR modulator and exhibits an EC₅₀ value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research .

HY-14832

Ataluren 5+ Cited Publications PTC124	CFTR Autophagy	Metabolic Disease Cancer
Ataluren (PTC124) is an orally available *CFTR-G542X* nonsense allele inhibitor.

HY-B0679

Lubiprostone 1 Publications Verification RU-0211; SPI-0211	Chloride Channel CFTR Glutathione Peroxidase NO Synthase TNF Receptor	Metabolic Disease
Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of *CIC-2/CFTR* and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

HY-150090

SRI-41315 1 Publications Verification	CFTR	Inflammation/Immunology
SRI-41315 induces a prolonged pause at stop codons and suppresses PTCs (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring *CFTR* (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity .

HY-N6818

5,7,4'-Trimethoxyflavone 2 Publications Verification TMF	Apoptosis Caspase PARP Endogenous Metabolite CFTR	Cancer
5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a *CFTR* activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-111099

GLPG1837 2 Publications Verification ABBV-974	CFTR Autophagy	Others
GLPG1837 is a potent and reversible *CFTR* potentiator, with EC₅₀s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.

HY-18336

GlyH-101 5 Publications Verification	CFTR	Cardiovascular Disease
GlyH-101 is a potent *CFTR* inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current .

HY-N2057

Steviol	Aquaporin CFTR Chloride Channel	Metabolic Disease
Steviol is the main metabolite of steviol glycosides and an inhibitor of *AQP2/CFTR. Steviol slows down the growth of renal cysts by inhibiting the activity of CFTR, reducing the expression of AQP2, and promoting the degradation of AQP2* and *CFTR*. Steviol can be used in the research of polycystic kidney disease .

HY-145603A

(R)-Vanzacaftor 1 Publications Verification (R)-VX-121	CFTR	Inflammation/Immunology
(R)-Vanzacaftor ((R)-VX-121) is a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulator with max activity of 30-60% and EC₅₀ <1 μM in enteroid cells. (R)-Vanzacaftor can be used for the research of cystic fibrosis .

HY-126394

Bamocaftor 1 Publications Verification VX-659	CFTR	Endocrinology
Bamocaftor (VX-659) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore *F508del-CFTR* protein function. Bamocaftor can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research .

HY-111772A

(R)-Elexacaftor (R)-VX-445	Drug Isomer CFTR	Inflammation/Immunology
(R)-Elexacaftor ((R)-VX-445) is the enantiomer of Elexacaftor (HY-111772). Elexacaftor is an orally active *CFTR* modulator that targets nucleotide-binding domain 1. Elexacaftor stabilizes misfolded *F508del-CFTR* protein, enhances its trafficking to the plasma membrane, and significantly improves metabolic stability, thermal stability and ion conductivity. Elexacaftor not only restores chloride transport function in nasal epithelial cells and rescues multiple CFTR mutation subtypes, but also exerts multiplicative synergistic effects with Ivacaftor (HY-13017), and is often used in a triple combination therapy with Tezacaftor (HY-15448). Elexacaftor is widely used in basic and clinical translational research on cystic fibrosis .

HY-18337

IOWH-032 4 Publications Verification	CFTR SARS-CoV	Infection Metabolic Disease
IOWH-032 is a a synthetic anti-secretory molecule, is a potent *CFTR* inhibitor with an IC₅₀ value of 8 μM. IOWH-032 also is a anti-diarrheal agent .

HY-111111

Galicaftor 1 Publications Verification ABBV-2222; GLPG-2222	CFTR	Inflammation/Immunology
Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research .

HY-14179

PPQ-102 4 Publications Verification CFTR Inhibitor	CFTR	Others
PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits *CFTR* chloride currents (IC₅₀ ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease .

HY-111680

Nesolicaftor 2 Publications Verification PTI-428	CFTR Autophagy	Endocrinology
Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier .

HY-109177

Icenticaftor QBW251	CFTR	Inflammation/Immunology
Icenticaftor (QBW251) is an orally active *CFTR* channel potentiator, with EC₅₀s of 79 nM and 497 nM for F508del and G551D CFTR, respectively. Icenticaftor can be used for chronic obstructive pulmonary disease (COPD) and cystic fibrosis research .

HY-109027

Cavosonstat 1 Publications Verification N91115	GSNOR CFTR	Inflammation/Immunology
Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor. Cavosonstat is a CFTR stabilizer, and can be used for cystic fibrosis research .

HY-109187A

Posenacaftor sodium 1 Publications Verification PTI-801 sodium	CFTR	Inflammation/Immunology
Posenacaftor (PTI-801) sodium is a *cystic fibrosis transmembrane regulator (CFTR) protein* modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF) .

HY-15448S

Tezacaftor-d4 VX-661-d₄	CFTR Autophagy	Cancer
Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor (HY-15448), a F508del CFTR corrector. Tezacaftor helps *CFTR* protein reach the cell surface .

HY-150089

SRI-37240	CFTR	Inflammation/Immunology
SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses *CFTR* nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418 .

HY-19778

(R)-BPO-27 3 Publications Verification	CFTR Autophagy	Inflammation/Immunology
(R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive *CFTR* inhibitor with an IC₅₀ of 4 nM.

HY-15206S1

Glyburide-d3 Glyburide-d₃	Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15448A

(Rac)-Tezacaftor (Rac)-VX-661	CFTR	Inflammation/Immunology
(Rac)-Tezacaftor ((Rac)-VX-661) is a racemate of Tezacaftor (HY-15448). Tezacaftor is a F508del CFTR corrector. (Rac)-Tezacaftor can be used for the research of cystic fibrosis .

HY-152264

CFTR activator 1	CFTR	Inflammation/Immunology
CFTR activator 1 is a potent and selective *CFTR* activator, with an EC₅₀ of 23 nM. CFTR activator 1 can be used to ameliorate dry eye disease .

HY-158002

IDOR-4	CFTR	Inflammation/Immunology
IDOR-4 is a type IV *CFTR* corrector. IDOR-4 restores F508del-CFTR trafficking to the cell surface .

HY-119229

VRT-325	CFTR	Inflammation/Immunology
VRT-325 is a *CFTR* modulator. VRT-325 inhibits disulfide cross-linking between cysteines in transmembrane segments 6 and 7 of CFTR and P-gp. VRT-325 promotes maturation of CFTR and P-gp processing mutants, rescues ΔF508-CFTR folding at the endoplasmic reticulum. VRT-325 binds ΔF508-CFTR nucleotide-binding domain 1, and increases mature ΔF508-CFTR cell surface expression and chloride conductance. VRT-325 can be used for the research of cystic fibrosis ^[1] ^[3].

HY-135279

CFTR corrector 4	CFTR	Inflammation/Immunology
CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis .

HY-13017S2

Ivacaftor-d18 VX-770-d₁₈	Autophagy CFTR	Endocrinology
Ivacaftor-d₁₈ is the deuterium labeled Ivacaftor . Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively .

HY-115878

NJH-2-057	CFTR	Others
NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds *ΔF508-CFTR*.

HY-119936

GLPG2451	CFTR Autophagy	Inflammation/Immunology
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC₅₀ of 11.1 nM .

HY-158991

I1421	CFTR	Inflammation/Immunology
I1421 is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) with an EC50 of 64 nM for WT CFTR currents. I1421 also allosterically activates multiple mutants causing cystic fibrosis (CF) with good in vivo potency, with an oral bioavailability of 60% in mice corresponding to a half-life of 75 min. I1421 synergizes with Elexacaftor (HY-111772) to enhance CFTR currents .

HY-19970

KM11060 2 Publications Verification	CFTR Autophagy	Endocrinology
KM11060 is a corrector of the F508 deletion (F508del)-cystic fibrosis transmembrane conductance regulator (CFTR) trafficking defect. KM11060 can be used for the research of F508del-CFTR processing defect and development of cystic fibrosis research .

HY-109152

Navocaftor 1 Publications Verification GLPG 3067; ABBV-3067	CFTR	Others
Navocaftor (GLPG 3067), as a cystic fibrosis transmembrane regulator (CFTR), is a protein modulator (US 20200377491 Al, example 1) .

HY-112267

Olacaftor VX-440	CFTR Autophagy	Inflammation/Immunology
Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408.

HY-147249

CFTR corrector 8	CFTR	Inflammation/Immunology
CFTR corrector 8 is a potent *CFTR* modulator. CFTR can be used in the research of cystic fibrosis .

HY-159706

S9-A13	Chloride Channel	Others
S9-A13 is a potent and selective inhibitor SLC26A9, with the IC₅₀ of 90.9 nM, without inhibiting other members of the SLC26 family such as SLC26A3, SLC26A4, and SLC26A6. S9-A13 can inhibits SLC26A9 Cl ^- currents in cells that lack expression of CFTR .

HY-W984122

CFTR corrector 17	CFTR	Inflammation/Immunology
CFTR corrector 17 is an isoxazole compound and *CFTR* modulator. CFTR corrector 17 can be used for the research of cystic fibrosis .

HY-13017S3

Ivacaftor-d4 VX-770-d₄	CFTR	Endocrinology
Ivacaftor-d4 (VX-770-d4) is the deuterium labeled-Ivacaftor (HY-13017). Ivacaftor is a potent and orally active *CFTR* potentiator, targeting *G551D-CFTR* and *F508del-CFTR* with EC₅₀s of 100 nM and 25 nM, respectively .

HY-14832R

Ataluren (Standard) 1 Publications Verification PTC124 (Standard)	Reference Standards CFTR Autophagy	Metabolic Disease Cancer
Ataluren (Standard) is the analytical standard of Ataluren. This product is intended for research and analytical applications. Ataluren (PTC124) is an orally available *CFTR-G542X* nonsense allele inhibitor.

HY-136939

CFTR corrector 6	CFTR	Metabolic Disease Inflammation/Immunology
CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research .

HY-125381

CFTR corrector 2 1 Publications Verification	CFTR Autophagy	Inflammation/Immunology Cancer
CFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933 .

HY-158144

GLPG2737	CFTR	Others
GLPG2737 is a potent *CFTR* type 2 corrector, and GLPG2737 can be used in combination with a type 1 co-corrector in the study of cystic fibrosis .

HY-114725

VRT-532 CFpot-532	CFTR	Inflammation/Immunology
VRT-532 (CFpot-532) is a potent is a potent *CFTR* modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis .

HY-145603S

Vanzacaftor-d4 VX-121-d₄	Isotope-Labeled Compounds CFTR Chloride Channel	Neurological Disease
Vanzacaftor-d₄ (VX-121-d₄) is the deuterium labeled Vanzacaftor (HY-145603). Vanzacaftor is an orally active noval corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves processing and trafficking of CFTR protein as well as increases chloride transport in triple combined with Tezacaftor (HY-15448) and Deutivacaftor. Vanzacaftor-Tezacaftor-Deutivacaftor is safe and well tolerated, improving lung function, respiratory symptoms, and CFTR function with cystic fibrosis, which is promising for research in the field of cystic fibrosis diseases .

Cat. No.	Product Name

HY-L011

Membrane Transporter/Ion Channel Compound Library

2,136 compounds

Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development.

MCE designs a unique collection of 2,136 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Type

HY-D1297

ER-Tracker Green

5+ Cited Publications

Fluorescent Dye

ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation .

HY-D1431

ER-Tracker Red

4 Publications Verification

Fluorescent Dye

HY-D1429

ER-Tracker Blue-White DPX

Fluorescent Dye

HY-DY1074

ER-Tracker Blue-White DPX (solution)

Fluorescent Dye

ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206) , highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining fixed cells. Staining followed by fixation is possible, but cells fixed with aldehydes will only retain partial fluorescence .
Solvent and concentration: DMSO: 1 mM

HY-DY1043

ER-Tracker Green (solution)

Fluorescent Dye

ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206) , highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation .
Solvent and concentration: DMSO: 1 mM

HY-DY1026

ER-Tracker Red (solution)

Fluorescent Dye

ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206) , highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation. Ex/Em=587/615 nm .
Solvent and concentration: DMSO: 1 mM

Cat. No.	Product Name	Target	Research Area

HY-P10226

PGD97	Chloride Channel CFTR	Endocrinology
PGD97 is a selective cyclic peptide inhibitor against *CAL/CFTR* interactions, with a K_D value of 6 nM towards the CAL PDZ domain for its desulfide cyclized form. PGD97 (desulfide cyclized form) has selectivity ≥ 130-fold compared to NHERF1/2 PDZ domains. PGD97 is capable of stabilizing F508del-CFTR at the cell membrane and improving CFTR function required for proper fluid homeostasis in tne lung. PGD97 can be used for the research of cystic fibrosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6818

5,7,4'-Trimethoxyflavone 2 Publications Verification TMF	Structural Classification Flavonoids Classification of Application Fields Flavones Kaempferia parviflora Wall. ex Baker Plants Disease Research Fields Source Classification Zingiberaceae Cancer	Apoptosis Caspase PARP Endogenous Metabolite CFTR
5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a *CFTR* activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-N2057

Steviol	Other Terpenoids Structural Classification other families Classification of Application Fields Terpenoids Metabolic Disease Plants Disease Research Fields Sweeteners Source Classification Food Research	Aquaporin CFTR Chloride Channel
Steviol is the main metabolite of steviol glycosides and an inhibitor of *AQP2/CFTR. Steviol slows down the growth of renal cysts by inhibiting the activity of CFTR, reducing the expression of AQP2, and promoting the degradation of AQP2* and *CFTR*. Steviol can be used in the research of polycystic kidney disease .

HY-N5101

Kobusin 1 Publications Verification	Structural Classification Magnoliaceae Lignans Phenylpropanoids Magnolia biondii Pamp. Plants Source Classification	CFTR Chloride Channel
Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel .

HY-N2057R

Steviol (Standard)	Other Terpenoids Structural Classification other families Terpenoids Plants Source Classification	Reference Standards Aquaporin CFTR Chloride Channel
Steviol (Standard) is the analytical standard of Steviol (HY-N2057). This product is intended for research and analytical applications. Steviol is the main metabolite of steviol glycosides and an inhibitor of *AQP2/CFTR. Steviol slows down the growth of renal cysts by inhibiting the activity of CFTR, reducing the expression of AQP2, and promoting the degradation of AQP2* and *CFTR*. Steviol can be used in the research of polycystic kidney disease .

HY-N6818R

5,7,4'-Trimethoxyflavone (Standard) TMF (Standard)	Structural Classification Flavonoids Flavones Kaempferia parviflora Wall. ex Baker Plants Source Classification Zingiberaceae	Reference Standards Apoptosis Caspase PARP Endogenous Metabolite CFTR
5,7,4'-Trimethoxyflavone (Standard) is the analytical standard of 5,7,4'-Trimethoxyflavone. This product is intended for research and analytical applications. 5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a CFTR activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703101

	CFTR Protein, Human (HEK293) ABCC7	Human	HEK293
	CFTR Protein, Human (HEK293) is the recombinant human-derived CFTR, expressed by HEK293 , with tag Free labeled tag.

HY-P72069

	ABCC1 Protein, Human (His) ABC 29; ABC29; ABCC 1; ABCC; Abcc1; ATP binding cassette sub family C CFTR/MRP; member 1; ATP binding cassette sub-family C member 1; ATP binding cassette subfamily C member 1; ATP binding cassette transporter variant ABCC1delta ex13; ATP binding cassette transporter variant ABCC1delta ex13&14; ATP binding cassette transporter variant ABCC1delta ex25; ATP binding cassette transporter variant ABCC1delta ex25&26; ATP binding cassette, sub-family C CFTR/MRP; , member 1; ATP-binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C4; transporter; LTC4 transporter; MRP 1; MRP; MRP1; MRP1_HUMAN; Multidrug resistance associated protein 1; Multidrug resistance protein; Multidrug resistance-associated protein 1; Multiple drug resistance associated protein; Multiple drug resistance protein 1	Human	E. coli
	ABCC1, Human (His) is a multitasking ATP-binding cassette (ABC) transporter. ABCC1, Human plays a part in inflammatory and other immunological diseases, age-related macular degeneration, cardiovascular disease, and certain neurological disorders as well as tumor progression.

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Cat. No.	Product Name	Chemical Structure

HY-13017S

Ivacaftor-d9
Ivacaftor-d₉ is a potent CFTR modulator and exhibits an EC₅₀ value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research .

HY-15448S

Tezacaftor-d4
Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor (HY-15448), a F508del CFTR corrector. Tezacaftor helps *CFTR* protein reach the cell surface .

HY-15206S1

Glyburide-d3

Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-13017S2

Ivacaftor-d18
Ivacaftor-d₁₈ is the deuterium labeled Ivacaftor . Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively .

HY-15206S

Glyburide-d11

Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

HY-13017S3

Ivacaftor-d4
Ivacaftor-d4 (VX-770-d4) is the deuterium labeled-Ivacaftor (HY-13017). Ivacaftor is a potent and orally active *CFTR* potentiator, targeting *G551D-CFTR* and *F508del-CFTR* with EC₅₀s of 100 nM and 25 nM, respectively .

HY-145603S

Vanzacaftor-d4

Vanzacaftor-d₄ (VX-121-d₄) is the deuterium labeled Vanzacaftor (HY-145603). Vanzacaftor is an orally active noval corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves processing and trafficking of CFTR protein as well as increases chloride transport in triple combined with Tezacaftor (HY-15448) and Deutivacaftor. Vanzacaftor-Tezacaftor-Deutivacaftor is safe and well tolerated, improving lung function, respiratory symptoms, and CFTR function with cystic fibrosis, which is promising for research in the field of cystic fibrosis diseases .

HY-13017S1

Ivacaftor-d19
Ivacaftor-d₉ is a potent *CFTR* modulator and exhibits an EC₅₀ value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research .

HY-15448S1

Tezacaftor-d6

Tezacaftor-d₆ (VX-661-d₆) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

HY-13017S4

Ivacaftor-13C6
Ivacaftor- ¹³C₆ (VX-770- ¹³C₆) is ¹³C labeled Ivacaftor. Ivacaftor (VX-770) is a potent and orally bioavailable *CFTR* potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively.

HY-B0679S

Lubiprostone-d7

Lubiprostone-d₇ (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

HY-14832S1

Ataluren-13C6
Ataluren- ¹³C₆ (PTC124- ¹³C₆) is ¹³C labeled Ataluren. Ataluren (PTC124) is an orally available *CFTR-G542X* nonsense allele inhibitor.

HY-15206S2

Glibenclamide-13C6

Glibenclamide- ¹³C₆ (Glyburide- ¹³C₆) is ¹³C labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K ⁺ channel (K_ATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of K_ATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

Host:	Mouse (2) Rabbit (3)
Reactivity:	Human (5) Mouse (1)
Application:	IHC-P (4) ICC/IF (2) IF-Tissue (1) IP (2) WB (3) FC (4) ELISA (2)
Isotype:	IgG (3) IgG1 (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (4) Recombinant (3)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81902

	PIST Antibody (YA1647) GOPC; CAL; CFTR-associated ligand; GOPC1; FIG; PIST	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse
	PIST Antibody (YA1647) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIST.

HY-P83773

	CFTR Antibody(YA3569) ABC 35 antibody ABC35 antibody ABCC 7 antibody ABCC7 antibody ATP binding cassette sub family C member 7 antibody; cAMP dependent chloride channel antibody; cAMP-dependent chloride channel antibody; CF antibody; CFTR antibody; CFTR/MRP antibody; CFTR_HUMAN antibody; Channel conductance controlling ATPase antibody; Channel conductance-controlling ATPase antibody; Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7) antibody; Cystic fibrosis transmembrane conductance regulator antibody; Cystic Fibrosis Transmembrane Regulator antibody; dJ760C5.1 antibody; MRP 7 antibody; MRP7 antibody; TNR CFTR antibody	WB, IHC-P, IP, IF-Tissue	Human
	CFTR Antibody(YA3569) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CFTR.

HY-P83833

	MRP4 Antibody (YA3530) MRP4; MOATB; MOAT-B; EST170205; ABCC 4 antibody; ABCC4 antibody; ATP binding cassette sub family C (CFTR/MRP) member 4 antibody; ATP binding cassette sub family C member 4 antibody	IHC-P, FC, ELISA	Human
	MRP4 Antibody (YA3530) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MRP4.

HY-P83833A

	MRP4 Antibody (YA3530)(PBS only) MRP4; MOATB; MOAT-B; EST170205; ABCC 4 antibody; ABCC4 antibody; ATP binding cassette sub family C (CFTR/MRP) member 4 antibody; ATP binding cassette sub family C member 4 antibody	IHC-P, FC, ELISA	Human
	MRP4 Antibody (YA3530) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MRP4.

HY-P81118

	MRP2 Antibody (YA3526) 1 Publications Verification ABC30 antibody; abcC2 antibody; ATP binding cassette sub family C (CFTR/MRP) member 2 antibody; ATP binding cassette subfamily C member 2 antibody; ATP-binding cassette sub-family C member 2 antibody; Canalicular multidrug resistance protein antibody; Canalicular multispecific organic anion transporter 1 antibody; CMOAT antibody; CMOAT1 antibody; cMRP antibody; DJS antibody; KIAA1010 antibody; MRP 2 antibody; MRP2_HUMAN antibody; Multidrug resistance associated protein 2 antibody; Multidrug resistance-associated protein 2 antibody;	WB, ICC/IF, FC	Human
	MRP2 Antibody (YA3526) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MRP2.

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Cat. No.	Product Name		Classification

HY-174821

VU439		Alkynes
VU439 is a functionalized photoaffinity ligand of Elexacaftor (HY-111772). VU439 retains the activity of Elexacaftor as a *CFTR* corrector and can identify SCCPDH as a specific off-target of Elexacaftor through chemoproteomics .

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