Search Result

Isoforms Recommended:	COX-1

Results for "

COX-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (369) 17β-HSD (1) Acyltransferase (2) Adrenergic Receptor (1) Akt (7) Aldose Reductase (3) AMPK (1) Amyloid-β (1) Androgen Receptor (1) Antibiotic (8) Apoptosis (83) ATP Synthase (1) Autophagy (28) Bacterial (20) Bcl-2 Family (4) Beta-lactamase (1) Beta-secretase (1) Calcium Channel (4) CaMK (1) Carbonic Anhydrase (3) Caspase (17) CFTR (4) Cholinesterase (ChE) (1) CMV (2) Collagen (1) CXCR (1) Cytochrome P450 (4) Dengue Virus (1) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (9) EGFR (4) Elastase (1) Endogenous Metabolite (21) Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (4) Environmental Pollutants (3) ERK (4) Estrogen Receptor/ERR (4) FAAH (4) FAK (1) Ferroptosis (4) FLAP (1) Fungal (1) GLUT (2) Glutathione Peroxidase (1) Glycosidase (2) HDAC (1) Heme Oxygenase (HO) (1) HIF/HIF Prolyl-Hydroxylase (1) HIV Protease (1) HSV (2) IKK (6) Influenza Virus (14) Interleukin Related (13) Isotope-Labeled Compounds (54) JNK (4) Keap1-Nrf2 (3) Lactate Dehydrogenase (1) Lipoxygenase (13) LOX-1 (2) Macrophage migration inhibitory factor (MIF) (2) MAP3K (2) Mitochondrial Metabolism (2) Mitophagy (7) MMP (7) MOFs (1) Monoamine Oxidase (3) MyD88 (1) Na+/K+ ATPase (1) NF-κB (28) NO Synthase (15) Nuclear Factor of activated T Cells (NFAT) (1) OAT (1) Oxidative Phosphorylation (1) p38 MAPK (14) Parasite (14) PERK (1) PGE synthase (15) Phosphodiesterase (PDE) (3) Phospholipase (1) PKA (1) PKC (1) PPAR (3) Prostaglandin Receptor (14) Quinone Reductase (1) Raf (1) RANKL/RANK (2) RAR/RXR (1) Reactive Oxygen Species (ROS) (9) Reference Standards (80) SARS-CoV (2) Serotonin Transporter (1) Sirtuin (2) Small Interfering RNA (siRNA) (5) SOD (5) Sodium Channel (1) Src (1) STAT (1) TGF-β Receptor (1) TNF Receptor (12) TRP Channel (1) Tyrosinase (1) VEGFR (3) Virus Protease (9) Xanthine Oxidase (1)
By Research Areas:	Cancer (186) Cardiovascular Disease (25) Endocrinology (10) Infection (52) Inflammation/Immunology (324) Metabolic Disease (32) Neurological Disease (58)
Click Chemistry:	Azide (1) Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) Cholesterol (1) siRNAs (5)

412

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: COX

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14397

Indomethacin Maximum Cited Publications 76 Publications Verification Indometacin	COX Antibiotic Influenza Virus Bacterial	Inflammation/Immunology Cancer
Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research ^[1] .

HY-N0898

Catechin Maximum Cited Publications 20 Publications Verification (+)-Catechin; Cianidanol; Catechuic acid	COX Apoptosis Influenza Virus Endogenous Metabolite	Cancer
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-15036

Diclofenac 20+ Cited Publications	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a *COX* inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells ^[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15030

Naproxen 5+ Cited Publications (S)-Naproxen	COX Autophagy	Inflammation/Immunology Cancer
Naproxen is a *COX-1* and *COX-2* inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively in cell assay.

HY-15038

Diclofenac potassium 20+ Cited Publications	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a *COX* inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells ^[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-78131A

(S)-(+)-Ibuprofen Dexibuprofen	COX	Inflammation/Immunology Cancer
(S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent *COX-1* and *COX-2* inhibitor with IC₅₀s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects ^[1] .

HY-59105

SC-560 3 Publications Verification	COX	Cancer
SC-560 is a potent and selective *COX-1* inhibitor with an IC₅₀ of 9 nM.

HY-15030A

Naproxen sodium 5+ Cited Publications	Autophagy COX	Inflammation/Immunology Cancer
Naproxen sodium is a *COX-1* and *COX-2* inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively in cell assay.

HY-N0356

(-)-Catechin gallate 4 Publications Verification (-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate	COX	Cancer
(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of *COX-1* and *COX-2* enzymes.

HY-15037

Diclofenac Sodium 20+ Cited Publications GP 45840	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a *COX* inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells ^[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-118827

Vedaprofen Quadrisol; CERM 10202; PM 150	COX	Inflammation/Immunology
Vedaprofen (Quadrisol) is a *COX-1* selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition ^[1]. Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC₅₀ of 222 μM .

HY-N0355

(+)-Catechin hydrate Maximum Cited Publications 20 Publications Verification	COX	Cancer
(+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-B2137

S-(+)-Ketoprofen 2 Publications Verification (S)-Ketoprofen; Dexketoprofen	COX	Inflammation/Immunology
S-(+)-Ketoprofen is a potent inhibitor of both *COX-1* and *COX-2* with IC₅₀s of 1.9 and 27 nM, respectively.

HY-15036A

Diclofenac diethylamine 20+ Cited Publications	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a *COX* inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells ^[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15036S

Diclofenac-d4	Isotope-Labeled Compounds COX Apoptosis	Inflammation/Immunology
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells ^[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-14397A

Indomethacin sodium hydrate Maximum Cited Publications 76 Publications Verification Indometacin sodium hydrate	COX Bacterial Influenza Virus Antibiotic	Infection Neurological Disease Inflammation/Immunology Cancer
Indomethacin (Indometacin) sodium hydrateis a orally active and BBB-permeable COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium hydrateis has anticancer activity and anti-infective activity. Indomethacin sodium hydrateis can be used for cancer, inflammation and viral infection research ^[1] .

HY-N0389

Columbin 1 Publications Verification	COX Parasite	Inflammation/Immunology
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits *COX-2* (EC₅₀=53.1 μM) over COX-1 (EC₅₀=327 μM) ^[1] .

HY-B0619

Zaltoprofen 2 Publications Verification CN100	COX	Inflammation/Immunology
Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active *COX-2* inhibitor, with IC₅₀s of 1.3 and 0.34 μM for *COX-1* and *COX-2*, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain ^[1] .

HY-W012817

Methylhydroquinone	Environmental Pollutants COX	Inflammation/Immunology
Methylhydroquinone is an orally active *COX* inhibitor with IC₅₀s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions ^[1] .

HY-15123

(S)-Flurbiprofen 2 Publications Verification Esflurbiprofen	COX PGE synthase	Inflammation/Immunology
(S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC₅₀ values of 0.48 μM and 0.47 μM for *COX-1* and *COX-2*, respectively ^[1].

HY-14837

Amizon Enisamium iodide	Influenza Virus SARS-CoV	Infection
Amizon is an orally effective antiviral and anti-inflammatory agent. Amizon inhibits influenza virus replication and restricts viral RNA synthesis. Amizon reduces the mRNA expression of *COX-1, COX-2, NF-κB, TGF1β, IL-1* and IL-6, and stimulates the secretion and mRNA expression of IL-10. Amizon inhibits the oxidative activity of macrophages and possesses antioxidant and free radical-scavenging activities. Amizon is applicable to research related to influenza and acute respiratory viral infections ^[1] .

HY-15037R

Diclofenac Sodium (Standard) GP 45840 (Standard)	Reference Standards COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (Sodium) (Standard) is the analytical standard of Diclofenac (Sodium). This product is intended for research and analytical applications. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a *COX* inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells ^[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-120824

Mofezolac 2 Publications Verification	COX	Inflammation/Immunology
Mofezolac, a non-steroidal anti-inflammatory drug (NSAID), is a selective, reversible and orally active *COX-1* inhibitor with an IC₅₀ of 1.44 nM. Mofezolac shows weak inhibitory activity on COX-2 (IC₅₀ of 447 nM). Mofezolac can relieve pain and has anti-inflammatory activities ^[1].

HY-E70229

Cyclooxygenase 1, sheep COX-1	Endogenous Metabolite	Metabolic Disease
Cyclooxygenase 1, sheep (COX-1) is a 71 kDa membrane bound protein predominantly present in endoplasmic reticulum. Cyclooxygenase 1 has three domains, the epidermal growth factor (EGF) like domain, enzymatic and membrane binding domain. Cyclooxygenase 1 mediates prostaglandin synthesis and is modulated by anti-inflammatory nonsteroidal drugs ^[1].

HY-N8167

Plantanone B Kaempferol 3-O-rhamnosylgentiobioside	COX	Inflammation/Immunology
Plantanone B is a moderate antioxidant-agent with an IC₅₀ of 169.8±5.2 μM. Plantanone B shows significant ovine COX-1 and moderate COX-2 inhibitory activities. Plantanone B has the potential for inflammation-related diseases research ^[1].

HY-15036R

Diclofenac (Standard)	Reference Standards COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (Standard) is the analytical standard of Diclofenac. This product is intended for research and analytical applications. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells ^[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-B2158

Chlorotrianisene	Estrogen Receptor/ERR COX	Cardiovascular Disease Endocrinology
Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme *COX-1* and inhibits platelet aggregation in whole blood ^[1] .

HY-78131AR

(S)-(+)-Ibuprofen (Standard) Dexibuprofen (Standard)	Reference Standards COX	Inflammation/Immunology
(S)-(+)-Ibuprofen (Standard) is the analytical standard of (S)-(+)-Ibuprofen. This product is intended for research and analytical applications. (S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent *COX-1* and *COX-2* inhibitor with IC₅₀s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects ^[1] .

HY-112731

TFAP N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide	COX Endogenous Metabolite	Metabolic Disease
TFAP is a selective cyclooxygenase-1 *(COX-1)* inhibitor, with an IC₅₀ of 0.8 μM.

HY-W009347

COX-1-IN-3	COX	Inflammation/Immunology
COX-1-IN-3 (compound 19) is a *COX-1* inhibitor with non-steroidal anti-inflammatory activity ^[1].

HY-15036S1

Diclofenac-13C6	Isotope-Labeled Compounds COX Apoptosis	Inflammation/Immunology
Diclofenac- ¹³C₆ is the ¹³C₆ labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-14397R

Indomethacin (Standard) Indometacin (Standard)	Reference Standards COX Antibiotic Influenza Virus Bacterial	Inflammation/Immunology Cancer
Indomethacin (Standard) is the analytical standard of Indomethacin. This product is intended for research and analytical applications. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research ^[1] .

HY-N8184

4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone	COX	Inflammation/Immunology
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone exhibits *COX-1* and *COX-2* inhibitory activity ^[1].

HY-15037S2

Diclofenac-13C6 sodium GP 45840-¹³C₆	Isotope-Labeled Compounds COX Apoptosis	Inflammation/Immunology
Diclofenac- ¹³C₆ (Sodium) is the ¹³C₆ labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15037S1

Diclofenac-d4 sodium	COX Apoptosis	Inflammation/Immunology
Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells ^[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-115966

COX-1/2-IN-1	COX	Inflammation/Immunology
COX-1/2-IN-2 is a potent *COX1/2* inhibitor. COX-1/2-IN-2 exhibits significant inhibitory effect against COX-1 and COX-2 inhibitor with IC₅₀ values of 13.9 ± 3.21 µM and 6.4±0.74 µM, respectively ^[1].

HY-78131AS

(S)-(+)-Ibuprofen-d3 (S)-Ibuprofen d₃	COX	Inflammation/Immunology
(S)-(+)-Ibuprofen-d₃ is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC₅₀s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects ^[1] .

HY-128473

Valeryl salicylate Valeroyl salicylate	COX	Inflammation/Immunology
Valeryl salicylate is a potent and irreversible **cyclooxygenase-1 (COX-1)** inhibitor. Valeryl salicylate shows anti-inflammatory effect ^[1].

HY-14397S

Indomethacin-d4 Indometacin-d₄	Isotope-Labeled Compounds COX Autophagy	Inflammation/Immunology Cancer
Indomethacin-d₄ (Indometacin-d₄) is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC₅₀s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells ^[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes .

HY-162167

COX-1-IN-1	COX	Cardiovascular Disease Neurological Disease
COX-1-IN-1 (compound 15a) is a selective inhibitor for cyclooxygenase (COX), with IC₅₀s of 0.23 μM (COX-1) and >50 μM (COX-2), selective index (COX-2 IC₅₀/COX-1 IC₅₀) is 217. COX-1-IN-1 inhibits platelet aggregation ^[1].

HY-15034

Indomethacin sodium INDOMETHACIN SODIUM	COX Antibiotic Influenza Virus Bacterial	Inflammation/Immunology Cancer
Indomethacin (Indometacin) sodium is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium has anticancer activity and anti-infective activity. Indomethacin sodium can be used for cancer, inflammation and viral infection research. ^[1] .

HY-134753

Teriflunomide impurity 3 4-Amino-N-(4-trifluoromethylphenyl)benzamide	COX	Inflammation/Immunology
Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective *COX-1* inhibitor with an IC₅₀ of 30 µM. Teriflunomide impurity 3 is less active against COX-2 (IC₅₀>100 µM) ^[1].

HY-N3555

(+)-Catechin pentaacetate	COX	Cancer
(+)-Catechin pentaacetate is a precursor for the production of (+) catechin (HY-N0898 ). (+) catechin is a useful natural herbicide and antimicrobial. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM ^[1] .

HY-15038R

Diclofenac potassium (Standard)	Reference Standards COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (potassium) (Standard) is the analytical standard of Diclofenac (potassium). This product is intended for research and analytical applications. Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells ^[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15036AR

Diclofenac diethylamine (Standard)	Reference Standards COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (diethylamine) (Standard) is the analytical standard of Diclofenac (diethylamine). This product is intended for research and analytical applications. Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells ^[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-N0389R

Columbin (Standard)	Reference Standards COX Parasite	Inflammation/Immunology
Columbin (Standard) is the analytical standard of Columbin. This product is intended for research and analytical applications. Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) ^[1] .

HY-N0932

Catechin hydrate (+)-Catechin hydrate; Cianidanol hydrate; Catechuic acid hydrate	COX	Cancer
Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-136720

ZXX2-77	COX	Others
ZXX2-77 is a cyclooxygenase-1 (COX-1) selective inhibitor belonging to the benzenesulfonylanilide class of compounds. It is reported as a novel analgesic that does not cause gastric damage. ZXX2-77 has a weak analgesic effect but exhibits potent COX-1 inhibitory activity in vitro. The low oral absorption rate of ZXX2-77 leads to its weak analgesic effect in vivo. At a dose of 30 mg/kg, the maximum plasma concentration of ZXX2-77 (1.2 mM) did not reach its COX-1 IC50 value (3.2 mM). In contrast, its derivative ZXX2-79, although weaker in vitro COX inhibitory activity, is better absorbed, exhibits stronger analgesic effect and hardly causes gastric damage. These findings suggest that ZXX2-77 and its derivatives as COX-1 selective inhibitors may become effective analgesics that do not cause gastric damage.

HY-111274

Indomethacin farnesil Indometacin farnesil	COX Autophagy	Inflammation/Immunology
Indomethacin farnesil is an orally active proagent of Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of *COX1* and *COX2, with IC₅₀s* of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes ^[1] .

HY-14397S1

Indomethacin-d4 Methyl Ester	COX Autophagy	Inflammation/Immunology Cancer
Indomethacin-d₄ Methyl Ester is the deuterium labeled Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC₅₀s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells ^[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes .

Cat. No.	Product Name

HY-L130

Non-steroidal Anti-Inflammatory Compound Library

627 compounds

Non-steroidal anti-inflammatory drugs (NSAIDs) are members of a therapeutic drug class with potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. The most prominent NSAIDs are aspirin, ibuprofen, and naproxen.

The main mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase (COX), based on which NSAIDs can be classified into two types: non-selective and COX-2 selective. Most NSAIDs are non-selective and inhibit both COX-1 and COX-2 activity.

MCE offers a unique collection of 627 non-steroidal compounds with identified anti-inflammatory activity. MCE non-steroidal anti-inflammatory library is a useful tool for the study of anti-inflammatory drugs and pharmacology.

HY-L914

Serine/Threonine Focused Covalent Fragment Library

3,208 compounds

In the research of covalent inhibitors targeting serine and threonine, scientists have found that the nucleophilicity of these hydroxyl groups is significantly enhanced due to the influence of their surrounding environment. This results in higher activity during catalytic reactions. Aspirin, which targets the non-catalytic domain serine (Ser529 in human COX1) of cyclooxygenase, exerts its anti-inflammatory effect through covalent binding. β-lactam antibiotics, which targets the catalytic domain serine of penicillin-binding proteins, interferes with bacterial cell wall synthesis.

Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 3,300 fragment molecules which can target serine and threonine residues and can be used for fragment-based covalent drug discovery.

Cat. No.	Product Name	Type

HY-14397G

Indomethacin

Indometacin

Fluorescent Dyes

Indomethacin (GMP) is Indomethacin (HY-14397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research ^[1] .

Cat. No.	Product Name	Type

HY-B2218D

Magnesium hydroxide, 99%(KT)

Magnesium dihydroxide, 99%(KT)

Biochemical Assay Reagents

Magnesium hydroxide (Magnesium dihydroxide), 99%(KT) is an orally effective antacid. Magnesium hydroxide, 99%(KT) can form a local strongly alkaline microenvironment, reduce ATP production by consuming H ⁺, and hydrolyze cellular phospholipids to disrupt the cellular integrity of microorganisms, thus exhibiting antibacterial activity. Magnesium hydroxide, 99%(KT) downregulates the generation of inflammatory macrophages to alleviate inflammatory responses. Magnesium hydroxide, 99%(KT) can be used in research related to acid peptic diseases and chronic wound infections ^[1] .

HY-14397G

Indomethacin

Indometacin

Biochemical Assay Reagents

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0898

Catechin Maximum Cited Publications 20 Publications Verification (+)-Catechin; Cianidanol; Catechuic acid	Structural Classification Classification of Application Fields Anti-aging Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Flavonoids Sunscreen Flavanols Phenols Polyphenols Cosmetic Research Disease Research Fields Source Classification Theaceae Cancer	COX Apoptosis Influenza Virus Endogenous Metabolite
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-N0001

(-)-Epicatechin 10+ Cited Publications (-)-Epicatechol; Epicatechin; epi-Catechin	Classification of Application Fields Anti-aging Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Flavonoids Sunscreen Flavanols Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Source Classification Theaceae Cancer	COX Ferroptosis Endogenous Metabolite
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N1067

Xanthohumol 15+ Cited Publications	Infection Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Phenols Polyphenols Plants Moraceae Disease Research Fields Source Classification	COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), *COX-1* and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, *HSV-1, HSV-2* and cytomegalovirus (CMV).

HY-B1227

Carprofen 5+ Cited Publications	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	COX FAAH Autophagy Endogenous Metabolite
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target *FAAH/COX* inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-N0002

(-)-Epicatechin gallate 5+ Cited Publications Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate	Structural Classification Flavonoids Classification of Application Fields Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae Cancer	COX Autophagy Virus Protease GLUT
(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 7.5 μM ^[1] . (-)-Epicatechin gallate is a *GLUT1* and GLUT5 inhibitor. (-)-Epicatechin gallate decreases cell growth of GLUT5-expressing hxt ⁰ yeast cells .

HY-N0356

(-)-Catechin gallate 4 Publications Verification (-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate	Flavonoids Classification of Application Fields Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae Cancer	COX
(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of *COX-1* and *COX-2* enzymes.

HY-15762

Valdecoxib 5 Publications Verification SC 65872	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	COX Endogenous Metabolite
Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX-1*, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-N0607

Ginsenoside Ro 1 Publications Verification Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Endocrinology Source Classification	Calcium Channel Prostaglandin Receptor
Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) exhibits a Ca ²⁺-antagonistic antiplatelet effect with an IC₅₀ of 155 μM. Ginsenoside Ro reduces the production of TXA₂ more than it reduces the activities of COX-1 and TXAS.

HY-B0367

Lornoxicam Chlortenoxicam; Ro 13-9297	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis COX NO Synthase Interleukin Related Prostaglandin Receptor TNF Receptor
Lornoxicam (Chlortenoxicam) is an orally active oxycontin nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antipyretic and anticancer activities. Lornoxicam exhibits good inhibitory effects on both *COX-1* and *COX-2* (COX-1: IC₅₀=0.005 μM; *COX-2:IC₅₀*=0.008 μM) and inhibits the production of NO by iNOS (IC₅₀=65 μM) and the proinflammatory cytokine IL-6 (IC₅₀=54 μM). Lornoxicam also inhibits tumor cell proliferation and migration and induces tumor cell apoptosis. Lornoxicam can be used in the study of inflammatory pain, colorectal cancer and breast cancer ^[1] .

HY-N0481

Roburic acid 1 Publications Verification	Triterpenes Structural Classification Gentiana macrophylla Pall. Classification of Application Fields Terpenoids Gentianaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	COX TNF Receptor NO Synthase Interleukin Related NF-κB Apoptosis p38 MAPK JNK ERK Keap1-Nrf2 RANKL/RANK
Roburic acid acts as an anti-inflammatory, anti-tumor and osteoclastogenesis inhibitor, with a K_i of 7.066 μM against human TNF, an IC₅₀ of 9 μM against human *COX-2, and an IC₅₀* of 5 μM against ovine *COX-1. Roburic acid reduces the production of inflammatory mediators such as NO and IL-6* in macrophages by inhibiting the NF-κB and MAPK (p38/JNK) pathways. By competitively inhibiting the *TNF-TNF-R1* interaction, Roburic acid blocks the downstream NF-κB signaling pathway, thereby inducing cell cycle arrest and apoptosis in cancer cells. Roburic acid specifically inhibits osteoclastogenesis and bone resorption by suppressing the *RANKL/TRAF6/NF-κB/NFATc1* axis. Roburic acid can be used in research related to osteolytic diseases such as osteoporosis, colorectal cancer and inflammatory diseases ^[1] .

HY-N0355

(+)-Catechin hydrate Maximum Cited Publications 20 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavanols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae Cancer	COX
(+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-N0898A

(-)-Catechin 4 Publications Verification (-)-Cianidanol; (-)-Catechuic acid	Flavonoids other families Classification of Application Fields Flavanols Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	COX
(-)-Catechin is Catechin's one kind of different structure. Catechin inhibitory enzyme-1 (COX-1), IC₅₀ of 1.4 μM. (-)-Catechin promotes hBM-MSC adipose cell differentiation, increases fat cell differentiation, and PPARγ level ^[1] .

HY-126052

Gnetol	Stilbenes Classification of Application Fields Phenols Polyphenols Gnetaceae Metabolic Disease Plants Disease Research Fields Gnetum montanum Markgr. Source Classification	COX Tyrosinase HDAC
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits *COX-1* (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities ^[1] .

HY-B1890

(±)-Catechin 1 Publications Verification rel-Cianidanol; rel-Catechuic acid	Infection Cardiovascular Disease Neurological Disease Classification of Application Fields Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Inflammation/Immunology Disease Research Fields Source Classification Theaceae	COX
(±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±)-Catechin has two forms, (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM. (-)-Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±)-Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects ^[1] .

HY-N2736

3′,4′,7-Trihydroxyflavone 1 Publications Verification	Flavonoids Classification of Application Fields Flavones Leguminosae Other Diseases Phenols Polyphenols Plants Vicia faba L. Disease Research Fields Source Classification	Beta-lactamase COX Interleukin Related Bacterial JNK ERK p38 MAPK STAT Apoptosis NO Synthase Nuclear Factor of activated T Cells (NFAT) Lactate Dehydrogenase Reactive Oxygen Species (ROS) SOD Akt Caspase Bcl-2 Family
3′,4′,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC₅₀ = 1.89 μM) and *COX-1* (IC₅₀ = 36.37 μM). 3′,4′,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-α. 3′,4′,7-Trihydroxyflavone inhibits H₂O₂-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the *JNK-STAT1* pathway. 3′,4′,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3′,4′,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via *NFATc1*. 3′,4′,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296)-induced memory deficits in mice ^[1] .

HY-N0346A

(E)-Ethyl p-methoxycinnamate	Infection Kaempferia galanga L. Classification of Application Fields Simple Phenylpropanols Alpinia officinarum Hance Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification Zingiberaceae Cancer	COX Glycosidase Caspase Apoptosis Mitochondrial Metabolism
(E)-Ethyl p-methoxycinnamate is a natural product found in Kaempferia galangal with anti-inflammatory, anti-neoplastic and anti-microbial effects. (E)-Ethyl p-methoxycinnamate inhibits *COX-1* and *COX-2* in vitro with IC₅₀s of 1.12 and 0.83 μM, respectively ^[1].

HY-113463

Cholesteryl eicosapentaenoate CE(20:5(5Z,8Z,11Z,14Z,17Z)	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite COX
Cholesteryl eicosapentaenoate (CE(20:5(5Z,8Z,11Z,14Z,17Z)), a cholesteryl ester, is a *COX-1* and *COX-2* inhibitor with IC₅₀ values of 14.6 μg/mL and 17.3 μg/mL, respectively. Cholesteryl eicosapentaenoate shows strong anti-inflammatory and antioxidant activities ^[1].

HY-N0920

Dihydrokavain 7,8-Dihydrokawain; 7,8-Dihydrokavain; Marindinin	Structural Classification Natural Products other families Plants Source Classification	COX Cytochrome P450
Dihydrokavain (7,8-Dihydrokawain) is a natural kavalactone compound. Dihydrokavain inhibits *COX-1, COX-2, CYP2C9* (IC₅₀ = 130.95 μM), CYP2C19 (IC₅₀ = 10.05 μM) and CYP3A4 (IC₅₀ = 78.59 μM). Dihydrokavain reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects ^[1] .

HY-N0396

Harpagoside 4 Publications Verification	Iridoids Classification of Application Fields Terpenoids Pedaliaceae Plants Harpagophytum procumbens Inflammation/Immunology Disease Research Fields	COX NO Synthase
Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on *COX-1* and *COX-2* active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ).

HY-N6962

α-Spinasterol	Structural Classification Plants Caryophyllaceae Melandrium firmum (S. et Z . ) Rohrb. Steroids	TRP Channel COX Bacterial
α-Spinasterol is an orally taken antagonist of transient receptor potential vanilloid 1 ( *TRPV1), and it's also an inhibitor of COX-1* and *COX-2, with IC₅₀* values of 16.17 μM and 7.76 μM, respectively. α-Spinasterol exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects, has the ability to cross the blood-brain barrier, and can improve diabetes in mice ^[1] .

HY-124481

Oleocanthal	Monophenols Canarium album (Lour.) Rauesch. Phenols Plants Burseraceae Source Classification	COX Reactive Oxygen Species (ROS) NO Synthase Keap1-Nrf2 Heme Oxygenase (HO) Amyloid-β Parasite
Oleocanthal is an orally active phenolic seciridoid compound. Oleocanthal can be extracted from olive oil. Oleocanthal inhibits *COX-1* and *COX-2, reduces ROS* and NO, and upregulates Nrf-2 and *HO-1. Oleocanthal reduces Aβ deposition. Oleocanthal exhibits anti-Leishmania activity against promastigotes and amastigotes of L. major, with IC₅₀* values of 18.7 and 87 μg/mL, respectively. Oleocanthal exhibits anticancer activity against colon, breast, liver, and melanoma cancers. Oleocanthal also exhibits anti-inflammatory and neuroprotective properties. Oleocanthal can be used in Alzheimer's disease research ^[1] .

HY-N0852

Benzoylpaeoniflorin	Cardiovascular Disease Structural Classification Other Monoterpenes Paeonia lactiflora Pall. Classification of Application Fields Terpenoids Plants Paeoniaceae Disease Research Fields Source Classification	p38 MAPK NF-κB Interleukin Related JNK PERK CXCR
Benzoylpaeoniflorin is an orally active monoterpene glycoside compound. Benzoylpaeoniflorin exerts anti-inflammatory, anti-allergic, psoriasis-improving and sepsis-improving effects by inhibiting signaling pathways such as TNF/NF-κB and MAPK, as well as regulating immune homeostasis. Benzoylpaeoniflorin can be used in research related to immune, allergic and inflammatory diseases ^[1] .

HY-N0389

Columbin 1 Publications Verification	other families Classification of Application Fields Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	COX Parasite
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits *COX-2* (EC₅₀=53.1 μM) over COX-1 (EC₅₀=327 μM) ^[1] .

HY-W012817

Methylhydroquinone	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Environmental Pollutants COX
Methylhydroquinone is an orally active *COX* inhibitor with IC₅₀s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions ^[1] .

HY-N0929

Hexahydrocurcumin	Classification of Application Fields Phenols Polyphenols Plants Curcuma longa Disease Research Fields Source Classification Zingiberaceae Cancer	COX Reactive Oxygen Species (ROS)
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active *COX-2* inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities ^[1] .

HY-N0898R

Catechin (Standard) (+)-Catechin (Standard); Cianidanol (Standard); Catechuic acid (Standard)	Structural Classification Flavonoids Microorganisms Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Source Classification Theaceae	Reference Standards COX Apoptosis Influenza Virus Endogenous Metabolite
Catechin (Standard) is the analytical standard of Catechin. This product is intended for research and analytical applications. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-126848

Diclofenac acyl glucuronide D-1-O-G	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Drug Metabolite SOD COX Reactive Oxygen Species (ROS) OAT
Diclofenac acyl glucuronide (D-1-O-G) is an orally active glucuronide metabolite of Diclofenac (HY-15036). Diclofenac acyl glucuronide exhibits SOD inhibitory activity, *COX-1* inhibitory activity (IC₅₀ = 0.620 μM), and *COX-2* inhibitory activity (IC₅₀ = 2.91 μM). Diclofenac acyl glucuronide induces reactive oxygen species (ROS) production and acts as a substrate of *OATP2B1*. Diclofenac acyl glucuronide induces small intestinal ulcers . Diclofenac acyl glucuronide can be used in research related to intestinal diseases and small intestinal ulcers ^[1] .

HY-N0001R

(-)-Epicatechin (Standard) 10+ Cited Publications (-)-Epicatechol(Standard); Epicatechin(Standard); epi-Catechin (Standard)	Classification of Application Fields Anti-aging Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Flavonoids Sunscreen Phenols Cosmetic Research Inflammation/Immunology Disease Research Fields Source Classification Theaceae Cancer	Reference Standards COX Ferroptosis Endogenous Metabolite
(-)-Epicatechin (Standard) is the analytical standard of (-)-Epicatechin. This product is intended for research and analytical applications. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N8167

Plantanone B Kaempferol 3-O-rhamnosylgentiobioside	Flavonols Flavonoids Classification of Application Fields Camellia oleifera Abel. Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification Theaceae	COX
Plantanone B is a moderate antioxidant-agent with an IC₅₀ of 169.8±5.2 μM. Plantanone B shows significant ovine COX-1 and moderate COX-2 inhibitory activities. Plantanone B has the potential for inflammation-related diseases research ^[1].

HY-112731

TFAP N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	COX Endogenous Metabolite
TFAP is a selective cyclooxygenase-1 *(COX-1)* inhibitor, with an IC₅₀ of 0.8 μM.

HY-B1890R

(±)-Catechin (Standard) rel-Cianidanol (Standard); rel-Catechuic acid (Standard)	Structural Classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Reference Standards COX
(±)-Catechin (Standard) is the analytical standard of (±)-Catechin. This product is intended for research and analytical applications. (±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±)-Catechin has two forms, (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. (-)-Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±)-Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects ^[1] .

HY-N0002R

(-)-Epicatechin gallate (Standard) 5+ Cited Publications Epicatechin gallate(Standard); ECG(Standard); (-)-Epicatechin 3-O-gallate (Standard)	Structural Classification Flavonoids Classification of Application Fields Phenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae Cancer	Reference Standards COX Autophagy Virus Protease GLUT
(-)-Epicatechin gallate (Standard) is the analytical standard of (-)-Epicatechin gallate. This product is intended for research and analytical applications. (-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 7.5 μM. (-)-Epicatechin gallate is a *GLUT1* and GLUT5 inhibitor. (-)-Epicatechin gallate decreases cell growth of GLUT5-expressing hxt ⁰ yeast cells .

HY-N8184

4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone	Dracaena cochinchinensis (Lour.) S. C. Chen Classification of Application Fields Phenols Polyphenols Agavaceae Plants Disease Research Fields Inflammation/Immunology Source Classification	COX
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone exhibits *COX-1* and *COX-2* inhibitory activity ^[1].

HY-B1227R

Carprofen (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards COX FAAH Autophagy Endogenous Metabolite
Carprofen (Standard) is the analytical standard of Carprofen. This product is intended for research and analytical applications. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-N1965

Gaultherin	other families Classification of Application Fields Ketones, Aldehydes, Acids Gaultheria yunnanensis Ericaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB p38 MAPK COX Monoamine Oxidase MMP Interleukin Related TNF Receptor Reactive Oxygen Species (ROS)
Gaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, *COX-2* (IC₅₀ = 0.35 mg/mL), LOX (IC₅₀ = 0.56 mg/mL) and HYAL (IC₅₀ = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654) ^[1] .

HY-126121

2-Hydroxy Ibuprofen (±)-2-Hydroxy Ibuprofen	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology Source Classification	COX
2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-N6891

Hamaudol 2 Publications Verification	Monophenols Classification of Application Fields Ophryosporus axilliflorus Hieron. Ketones, Aldehydes, Acids Phenols Plants Umbelliferae Disease Research Fields Inflammation/Immunology Source Classification	COX
Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and *COX-2* activities with IC₅₀ values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects ^[1] .

HY-N0929R

Hexahydrocurcumin (Standard)	Structural Classification Phenols Polyphenols Plants Curcuma longa Source Classification Zingiberaceae	Reference Standards COX Reactive Oxygen Species (ROS)
Hexahydrocurcumin (Standard) is the analytical standard of Hexahydrocurcumin. This product is intended for research and analytical applications. Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities ^[1] .

HY-N0346

4-Methoxycinnamic acid ethyl ester Ethyl p-methoxycinnamate	Structural Classification Kaempferia galanga L. Iridoids Terpenoids Plants Source Classification Zingiberaceae	COX NF-κB TNF Receptor Interleukin Related Apoptosis VEGFR Bacterial Dengue Virus Caspase
4-Methoxycinnamic acid ethyl ester (Ethyl p-methoxycinnamate) is an orally active natural compound found. 4-Methoxycinnamic acid ethyl ester exerts anti-inflammatory effects by inhibiting cyclooxygenase (COX-1 (IC₅₀ = 1.12 μM) and *COX-2* (IC₅₀ = 0.83 μM)), NF-κB (IC₅₀ = 88.7 μM) and cytokine production (TNF-α (IC₅₀ = 96.84 μg/mL) and *IL-1β* (IC₅₀ = 166.4 μg/mL)). 4-Methoxycinnamic acid ethyl ester inhibits tumor cell proliferation, migration and cancer metabolism and induces apoptosis.4-Methoxycinnamic acid ethyl ester inhibits VEGF expression, thereby inhibiting angiogenesis. 4-Methoxycinnamic acid ethyl ester has a significant inhibitory effect on dengue virus and Mycobacterium tuberculosis. 4-Methoxycinnamic acid ethyl ester has analgesic effects in rats ^[1] .

HY-N3555

(+)-Catechin pentaacetate	Natural Products Taxaceae Plants Source Classification Taxus wallichiana Zucc.	COX
(+)-Catechin pentaacetate is a precursor for the production of (+) catechin (HY-N0898 ). (+) catechin is a useful natural herbicide and antimicrobial. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM ^[1] .

HY-N0389R

Columbin (Standard)	Structural Classification other families Terpenoids Diterpenoids Plants Source Classification	Reference Standards COX Parasite
Columbin (Standard) is the analytical standard of Columbin. This product is intended for research and analytical applications. Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) ^[1] .

HY-N0932

Catechin hydrate (+)-Catechin hydrate; Cianidanol hydrate; Catechuic acid hydrate	Flavonoids Classification of Application Fields Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae Cancer	COX
Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-N0356R

(-)-Catechin gallate (Standard) (-)-Catechin 3-gallate (Standard); (-)-Catechin 3-O-gallate (Standard)	Structural Classification Flavonoids Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Reference Standards COX
(-)-Catechin gallate (Standard) is the analytical standard of (-)-Catechin gallate. This product is intended for research and analytical applications. (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.

HY-B0367R

Lornoxicam (Standard) Chlortenoxicam (Standard); Ro 13-9297 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards COX Endogenous Metabolite
Lornoxicam (Standard) is the analytical standard of Lornoxicam. This product is intended for research and analytical applications. Lornoxicam (Chlortenoxicam) is a highly active COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM respectively. It is a new non-steroidal anti-inflammatory compound.

HY-N0898AR

(-)-Catechin (Standard) (-)-Cianidanol (Standard); (-)-Catechuic acid (Standard)	Structural Classification Flavonoids other families Flavanols Phenols Polyphenols Plants Source Classification	Reference Standards COX
(-)-Catechin (Standard) is the analytical standard of (-)-Catechin. This product is intended for research and analytical applications. (-)-Catechin is Catechin's one kind of different structure. Catechin inhibitory enzyme-1 (COX-1), IC₅₀ of 1.4 μM. (-)-Catechin promotes hBM-MSC adipose cell differentiation, increases fat cell differentiation, and PPARγ level ^[1] .

HY-N1067R

Xanthohumol (Standard)	Structural Classification Chalcones Flavonoids Humulus lupulus L. Phenols Polyphenols Plants Moraceae Source Classification	Reference Standards COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol (Standard) is the analytical standard of Xanthohumol. This product is intended for research and analytical applications. Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-N0346AR

(E)-Ethyl p-methoxycinnamate (Standard)	Structural Classification Kaempferia galanga L. Simple Phenylpropanols Alpinia officinarum Hance Phenylpropanoids Plants Source Classification Zingiberaceae	Reference Standards COX Glycosidase Caspase Apoptosis Mitochondrial Metabolism
(E)-Ethyl p-methoxycinnamate (Standard) is the analytical standard of (E)-Ethyl p-methoxycinnamate. This product is intended for research and analytical applications. (E)-Ethyl p-methoxycinnamate is a natural product found in Kaempferia galangal with anti-inflammatory, anti-neoplastic and anti-microbial effects. (E)-Ethyl p-methoxycinnamate inhibits COX-1 and COX-2 in vitro with IC₅₀s of 1.12 and 0.83 μM, respectively ^[1].

HY-N10009

Cudraflavone B	Brosimopsis oblongifolia Phenols Polyphenols Plants Moraceae Source Classification	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of *COX-1* and *COX-2. Cudraflavone B blocks the translocation of nuclear factor κB* (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of *SIRT1*. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells ^[1] .

HY-122953

Daturaolone	Triterpenes Datura innoxia Miller Terpenoids Plants Solanaceae Source Classification	COX
Daturaolone is a natural triterpenoid with anti-inflammatory and antinociceptive potentials. Daturaolone displays a *COX-1* inhibitory activity ^[1].

HY-N3631

Ethoxycoronarin D	Hedychium coronarium Koen. Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology Source Classification Zingiberaceae	COX
Ethoxycoronarin D is a labdane diterpenes compound isolated from rhizomes. Ethoxycoronarin D selectively inhibits COX-1 with an IC₅₀ of 3.8 µM ^[1].

Cat. No.	Product Name	Chemical Structure

HY-78131S

Ibuprofen-d3 1 Publications Verification
Ibuprofen-d₃ is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM ^[1].

HY-15036S

Diclofenac-d4
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells ^[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-14654S1

Aspirin-d4

Aspirin-d₄ is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis ^[1] .

HY-14654S

Aspirin-d3

Aspirin-d₃ is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis ^[1] .

HY-15036S1

Diclofenac-13C6
Diclofenac- ¹³C₆ is the ¹³C₆ labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-B0261S

Meloxicam-d3
Meloxicam-d₃ is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC₅₀s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively ^[1].

HY-15321S

Etoricoxib-d4 1 Publications Verification
Etoricoxib-d₄ (MK-0663-d₄) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-17357S

Nepafenac-d5

Nepafenac-d₅ (AHR-9434-d₅; AL-6515-d₅) is the deuterium labeled Nepafenac (HY-17357). Nepafenac, a nonsteroidal anti-inflammatory agent, is a topically administered COX-2 inhibitor with an IC₅₀ of 0.12 μM. Nepafenac exhibits only weak COX-1 inhibitory activity (IC₅₀ = 64.3 μM). Nepafenac possesses unique prodrug properties, which enable it to rapidly convert into the active metabolite Amfenac (HY-17479) in the ocular tissues, thereby achieving high concentrations in the retina and choroid. Nepafenac reduces inflammation and pain by inhibiting the activity of cyclooxygenase (COX) enzymes and thereby decreasing the production of prostaglandin PGE_₂. Nepafenac can delay the metastasis of uveal melanoma (UM) in rabbit eyes. Nepafenac is mainly used for pain management and inflammation control after ophthalmic surgeries.

HY-15037S2

Diclofenac-13C6 sodium

Diclofenac- ¹³C₆ (Sodium) is the ¹³C₆ labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15037S1

Diclofenac-d4 sodium

Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells ^[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-B0227S

Ketoprofen-d3
Ketoprofen-d₃ is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC₅₀s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively ^[1].

HY-78131CS

Ibuprofen-d3 sodium

1 Publications Verification

Ibuprofen-d₃ ((±)-Ibuprofen-d₃) sodium is the deuterium labeled Ibuprofen sodium (HY-78131C). Ibuprofen sodium is an orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers ^[1] .

HY-78131S3

Ibuprofen-13C6

Ibuprofen- ¹³C₆ ((±)-Ibuprofen- ¹³C₆) is a ¹³C labeled Ibuprofen (HY-78131). Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers ^[1] .

HY-78131AS

(S)-(+)-Ibuprofen-d3
(S)-(+)-Ibuprofen-d₃ is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC₅₀s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects ^[1] .

HY-14397S

Indomethacin-d4
Indomethacin-d₄ (Indometacin-d₄) is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC₅₀s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells ^[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes .

HY-B0261S1

Meloxicam-d3-1
Meloxicam-d₃-1 is the deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-B1227S

Carprofen-d3
Carprofen-d₃ is the deuterium labeled Carprofen. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-B0261S4

Meloxicam-13C6
Meloxicam-13C6 is ¹³C₆-labeled Meloxicam (HY-B0261). Meloxicam is a non-steroidal antiinflammatory agent, inhibits *COX* activity, with IC₅₀s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively ^[1] .

HY-17509S

Deracoxib-d3

Deracoxib-d₃ (SC 046-d₃; SC 59046-d₃) is the deuterium labeled Deracoxib (HY-17509). Deracoxib, an orally active COX-2 inhibitor, is a veterinary nonsteroidal anti-inflammatory agent used exclusively in dogs. Deracoxib inhibits the COX-2 enzyme to reduce the production of prostaglandins, effectively controlling pain and inflammation after canine soft tissue surgery. Deracoxib reduces the inhibition of COX-1 and lowers the risk of gastrointestinal side effects. Deracoxib induces tumor cell cycle arrest and apoptosis, and shows anti-tumor activity in canine osteosarcoma, breast tumors and bladder transitional cell carcinomas.

HY-14397S1

Indomethacin-d4 Methyl Ester
Indomethacin-d₄ Methyl Ester is the deuterium labeled Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC₅₀s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells ^[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes .

HY-N0898S

Catechin-13C3 1 Publications Verification
Catechin- ¹³C₃ is the ¹³C-labeled Catechin. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.

HY-B0580S

Ketorolac-d5
Ketorolac-d₅ is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC₅₀s of 20 nM for COX-1 and 120 nM for COX-2 ^[1].

HY-78131S1

Ibuprofen-13C,d3
Ibuprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Ibuprofen. Ibuprofen is an anti-inflammatory agent targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively ^[1].

HY-B0261S2

Meloxicam-13C,d3
Meloxicam- ¹³C,d₃ is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-15030S1

Naproxen-d3
Naproxen-d₃ ((S)-Naproxen-d₃) is the deuterium labeled Naproxen (HY-15030). Naproxen is a COX-1 and COX-2 inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively in cell assay.

HY-B0253S

Piroxicam-d3
Piroxicam-d₃ (CP-16171-d₃) is deuterium labeled Piroxicam. Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC₅₀s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively ^[1].

HY-15321S2

Etoricoxib-d3
Etoricoxib-d₃ is the deuterium labeled Etoricoxib ^[1]. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood .

HY-B0335S1

Tolfenamic acid-13C6
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-14670S

Firocoxib-d4
Firocoxib-d₄ (ML 1785713-d₄) is the deuterium labeled Firocoxib. Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC₅₀ of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC₅₀ of 7.5 μM). Firocoxib has anti-inflammatory effects ^[1].

HY-78131S2

Ibuprofen-d4

Ibuprofen-d₄ is a deuterium labeled Ibuprofen (HY-78131). Ibuprofen is a potent, orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers ^[1] .

HY-17372S

Rofecoxib-d5
Rofecoxib-d₅ is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells) ^[1] .

HY-14397S2

Indometacin-d7
Indometacin-d₇ is deuterated labeled Indomethacin (HY-14397). Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research ^[1] .

HY-B0808S1

Oxaprozin-d5
Oxaprozin-d₅ is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.

HY-105028S

Tenidap-d3
Tenidap-d₃ is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC₅₀ values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties ^[1] . Tenidap is also a specific SLC26A3 inhibitor .

HY-B0367S

Lornoxicam-d4
Lornoxicam-d₄ is the deuterium labeled Lornoxicam. Lornoxicam (Chlortenoxicam), a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory agent (NSAID).

HY-14397S3

Indomethacin-13C6
Indomethacin- ¹³C₆ (Indometacin- ¹³C₆) is ¹³C labeled Indomethacin. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research ^[1] .

HY-15037S

Diclofenac-13C6 sodium heminonahydrate

Diclofenac- ¹³C₆ (sodium heminonahydrate) is the ¹³C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells ^[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-B2137S

S-(+)-Ketoprofen-d3
S-(+)-Ketoprofen-d₃ ((S)-Ketoprofen-d₃) is deuterium labeled S-(+)-Ketoprofen. S-(+)-Ketoprofen is a potent inhibitor of both *COX-1* and *COX-2* with IC₅₀s of 1.9 and 27 nM, respectively.

HY-B0253S1

Piroxicam-d4
Piroxicam-d₄ is the deuterium labeled Piroxicam. Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively.

HY-B0227S1

Ketoprofen-d4
Ketoprofen-d₄ is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC₅₀s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively ^[1].

HY-15762S

Valdecoxib-d3
Valdecoxib-d₃ is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain ^[1] .

HY-B2158S

Chlorotrianisene-d9
Chlorotrianisene-d₉ is the deuterium labeled Chlorotrianisene. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood ^[1] .

HY-W778002

(S)-(+)-Ketoprofen-13C,d3
(S)-(+)-Ketoprofen- ¹³C,d₃ is the deuterium and ¹³C-labeled S-(+)-Ketoprofen (HY-B2137). S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC₅₀s of 1.9 and 27 nM, respectively.

HY-15029S2

(±)-Naproxen-13C,d3
(±)-Naproxen- ¹³C,d₃ is the deuterium and ¹³C labeled (±)-Naproxen ^[1]. (±)-Naproxen ((Rac)-Naproxen) is a racemate of Naproxen (HY-15030). Naproxen is a COX-1 and COX-2 inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively.

HY-W745860

Hexahydrocurcumin-d6
Hexahydrocurcumin-d₆ is the deuterium labeled Hexahydrocurcumin (HY-N0929). Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities ^[1] .

HY-B0578S

Loxoprofen-d4
Loxoprofen-d₄ is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively ^[1] .

HY-B1799S

Tolmetin-d3
Tolmetin-d₃ is the deuterium labeled Tolmetin. Tolmetin is an orally active and potent COX inhibitor with IC₅₀s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID) ^[1] .

HY-118827S

Vedaprofen-d3
Vedaprofen-d₃ is the deuterium labeled Vedaprofen. Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition ^[1]. Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC₅₀ of 222 μM .

HY-B0227S2

Ketoprofen-13C,d3
Ketoprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC₅₀s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively ^[1].

HY-126121S

2-Hydroxy Ibuprofen-d6
2-Hydroxy Ibuprofen-d₆ is the deuterium labeled 2-Hydroxy Ibuprofen. 2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively ^[1] .

Host:	Rabbit (3)
Reactivity:	Human (3) Rat (3) Mouse (3)
Application:	IHC-P (3) ICC/IF (3) IF-Tissue (1) IP (2) IHC-F (2) WB (3) FC (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82792

	Cyclooxygenase 1 Antibody (YA2537) PTGS1; COX1; Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Cyclooxygenase 1 Antibody (YA2537) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclooxygenase 1.

HY-P82792A

	Cyclooxygenase 1 Antibody (YA2537)(PBS only) PTGS1; COX1; Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Cyclooxygenase 1 Antibody (YA2537) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclooxygenase 1.

HY-P86965

	MTCO1 Antibody (YA6658) COI antibody; COX I antibody; COX1 antibody; COX1_HUMAN antibody; COXI antibody; Cytochrome c oxidase polypeptide I antibody; Cytochrome c oxidase subunit 1 antibody; Cytochrome C Oxidase subunit I antibody; Mitochondrially encoded cytochrome c oxidase I antibody; MT CO1 antibody; COI antibody; COX I antibody; COX1 antibody; COX1_HUMAN antibody; COXI antibody; Cytochrome c oxidase polypeptide I antibody; Cytochrome c oxidase subunit 1 antibody; Cytochrome C Oxidase subunit I antibody; Mitochondrially encoded cytochrome c oxidase I antibody; MT CO1 antibody; MT-CO1 antibody; MTCO 1 antibody; MTCO1 antibody;	WB, ICC/IF, IHC-P, FC, IF-Tissue	Human, Mouse, Rat
	MTCO1 Antibody (YA6658) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MTCO1.

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Cat. No.	Product Name		Classification

HY-159561

COX-1-IN-2		Azide
COX-1-IN-2 (compound 5h) is an anti-inflammatory agent with potent analgesic activity. COX-1-IN-2 exhibits a significant inhibitory effect on *COX-1* (IC₅₀=38.76 nM) ^[1].

HY-127145

Parsalmide		Alkynes
Parsalmide is an orally active non-steroidal anti-inflammatory drug and gastroprotective agent, with an IC₅₀ of 9.92 μM against *COX-1* and 155 μM against *COX-2*. Parsalmide prevents gastric injury and reduces edema. Parsalmide can be used in the research of arthritis ^[1].

Targets Recommended: COX

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14397G

Indomethacin Indometacin	Antibiotic Influenza Virus Bacterial COX	Inflammation/Immunology Cancer
Indomethacin (GMP) is Indomethacin (HY-14397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research ^[1] .

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COX-1

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