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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
CRBN-6-5-5-VHL
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "CRBN-6-5-5-VHL" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
CRBN-6-5-5-VHL is a potent and selective VHL E3 ligand-based Cereblon (CRBN) PROTAC degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL forms a heterotrimeric complex with CRBN and VHL E3 ligase, thereby promoting CRBN ubiquitination and proteasomal degradation without inducing VHL degradation. CRBN-6-5-5-VHL protects myeloma from the toxic effects of IMiDs. CRBN-6-5-5-VHL can be used in the research of multiple myeloma .
Cat. No.: HY-403544
CAS No.: 2324147-95-5
Target:
Research Areas:
CbzNH-(C5-O)2-C4-Boc is a PROTAC linker. CbzNH-(C5-O)2-C4-Boc can be used for the synthesis of PROTAC CRBN-6-5-5-VHL (HY-136262) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
