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Carbamoyl Phosphate Synthetase (CPS)

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標的別:	Carbamoyl Phosphate Synthetase (CPS) (3) Drug Metabolite (1) Potassium Channel (1) Reference Standards (2)
研究分野別:	Cancer (4)

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組換えタンパク質

Targets Recommended: Carbamoyl Phosphate Synthetase (CPS) Sodium Phosphate Cotransporter Aminoacyl-tRNA Synthetase Acetyl-CoA synthetase Glucose-6-Phosphate Isomerase (GPI) Methionine Adenosyltransferase (MAT) PIKfyve PI4P5K

製品番号	製品名	Target	研究分野	構造式

HY-B0711

Carglumic Acid 2 Publications Verification N-Carbamyl-L-glutamic acid	Carbamoyl Phosphate Synthetase (CPS)	Cancer
Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.

HY-136128

H3B-120 1 Publications Verification	Potassium Channel Carbamoyl Phosphate Synthetase (CPS)	Cancer
H3B-120 is a highly selective, competitive and allosteric **carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC₅₀ of 1.5 μM and a K_i** of 1.4 μM. H3B-120 has anti-cancer activity .

HY-B0711R

Carglumic Acid (Standard) N-Carbamyl-L-glutamic acid (Standard)	Reference Standards Others	Cancer
Carglumic Acid (Standard) is the analytical standard of Carglumic Acid. This product is intended for research and analytical applications. Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.

HY-131275R

Imatinib Impurity E (Standard)	Drug Metabolite Reference Standards	Others
Carglumic Acid (Standard) is the analytical standard of Carglumic Acid. This product is intended for research and analytical applications. Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.

HY-183888

H3B-616	Carbamoyl Phosphate Synthetase (CPS)	Cancer
H3B-616 is a selective carbamoyl phosphate synthetase 1 (CPS1) inhibitor with a human IC₅₀ of 66 nM. H3B-616 binds to an allosteric pocket in the CPS1 integrating domain to exert target engagement and inhibit enzyme activity. H3B-616 can be used for the research of nonsmall cell lung cancer and gastric cancer .

製品番号	製品名	Category	Target	構造式

HY-B0711R

Carglumic Acid (Standard) N-Carbamyl-L-glutamic acid (Standard)	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Others
Carglumic Acid (Standard) is the analytical standard of Carglumic Acid. This product is intended for research and analytical applications. Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.

製品番号	Compare	製品名	Species	Source	Image

HY-P71445

	CPS1/CPSase I Protein, Human (sf9, His) Carbamoyl Phosphate synthase; Carbamoyl Phosphate synthase mitochondrial; Carbamoyl Phosphate synthase; Carbamoyl Phosphate Synthetase 1; Carbamoyl Phosphate Synthetase 1 mitochondrial; Carbamoyl Phosphate Synthetase I; Carbamoyl-Phosphate synthase [ammonia]; Carbamoyl-Phosphate Synthetase I; CarbamoylPhosphate synthase; CarbamoylPhosphate Synthetase 1; CarbamoylPhosphate Synthetase I; CPS 1; Cps1; CPSase 1; CPSase I; CPSASE1; mitochondrial; MS738	Human	Sf9 insect cells
	The CPS1/CPSase I protein is critical in participating in the urea cycle and is essential for the elimination of excess ammonia in urea-bearing animals. This essential enzyme converts toxic ammonia (a byproduct of amino acid catabolism) into urea, promoting safe excretion. CPS1/CPSase I Protein, Human (sf9, His) is the recombinant human-derived CPS1/CPSase I protein, expressed by sf9 insect cells , with His labeled tag.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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