Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
ClpX
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "ClpX" in MCE Product Catalog:
Cat. No.: HY-RS02835
Target:
Research Areas:
CLPX Human Pre-designed siRNA Set A contains three designed siRNAs for CLPX gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS22125
Target:
Research Areas:
Clpx Mouse Pre-designed siRNA Set A contains three designed siRNAs for Clpx gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS28647
Target:
Research Areas:
Clpx Rat Pre-designed siRNA Set A contains three designed siRNAs for Clpx gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-178912
Research Areas:
Anti-MRSA agent 39 is an orally active ClpX modulator that binds Staphylococcus aureus caseinolytic protease X (SaClpX) with high affinity (Kd = 3.6 μM). Anti-MRSA agent 39 exerts antibacterial effects through temperature-dependent inhibition of cell division. Anti-MRSA agent 39 elicits profound metabolic dysregulation in methicillin-resistant Staphylococcus aureus (MRSA), manifesting as significantly reduced ATP levels, elevated reactive oxygen species (ROS), and decreased NAD+/NADH ratio, and accelerates bacterial lysis rates in MRSA ATCC 33591. Anti-MRSA agent 39 significantly increases the proportion of MRSA cells in the mitotic phase, and the cells exhibit obvious morphological abnormalities. Anti-MRSA agent 39 can be used for the study of invasive MRSA infections .
Cat. No.: HY-189712
ADEP 19 is a ClpP1P2 dysregulator with antibacterial activity against Mycobacterium tuberculosis and various Gram-positive bacteria. ADEP 19 binds to the ClpP2 subunit of Mycobacterium tuberculosis, disrupting ClpP1P2-ClpX/ClpC1 chaperone interactions. ADEP 19 inhibits ClpC1P1P2-mediated proteolytic activity (IC50 = 1.2 μM) while upregulating the ATP hydrolysis activity of ClpXP1P2. ADEP 19 exhibits synergistic effects with Bedaquiline (HY-14881) against Mycobacterium tuberculosis. ADEP 19 can be used in research related to bacterial infections, such as tuberculosis .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
